Underground coal mine instrumentation and test

The need to evaluate mechanical performance of mine tools and to obtain test performance data from candidate systems dictate that an engineering data recording system be built. Because of the wide range of test parameters which would be evaluated, a general purpose data gathering system was designed and assembled to permit maximum versatility. A primary objective of this program was to provide a specific operating evaluation of a longwall mining machine vibration response under normal operating conditions. A number of mines were visited and a candidate for test evaluation was selected, based upon management cooperation, machine suitability, and mine conditions. Actual mine testing took place in a West Virginia mine

Relating Static and Dynamic Measurements for the Java Virtual Machine Instruction Set

It has previously been noted that, for conventional machine code, there is a strong relationship between static and dynamic code measurements. One of the goals of this paper is to examine whether this same relationship is true of Java programs at the bytecode level. To this end, the hypothesis of a linear correlation between static and dynamic frequencies was investigated using Pearson’s correlation coefficient. Programs from the Java Grande and SPEC benchmarks suites were used in the analysis

A Java Distributed Computation Library

This paper describes the design and development of a Java Distributed Computation Library, which provides a simple development platform for developers who wish to quickly implement a distributed computation in the context of an SPMD architecture (Single Program, Multiple Data). The need for this research arose out of the realisation that the currently available distributed computation libraries and systems do not adequately meet certain criteria, such as ease of development, dynamic changes to system behaviour, and easy deployment of distributed software. The proposed solution to this problem was to produce a Java-based distributed computation library which enables developers to use the Java language to quickly and easily implement a distributed computation. The results of experiments conducted using DCL are also presented, as a means of showing that DCL met its design goals

Independent Expert Scientific Panel – Report on Unconventional Oil and Gas

No abstract available

Relating Static and Dynamic Measurements for the Java Virtual Machine Instruction Set

It has previously been noted that, for conventional machine code, there is a strong relationship between static and dynamic code measurements. One of the goals of this paper is to examine whether this same relationship is true of Java programs at the bytecode level. To this end, the hypothesis of a linear correlation between static and dynamic frequencies was investigated using Pearson’s correlation coefficient. Programs from the Java Grande and SPEC benchmarks suites were used in the analysis

Measuring the impact of object-oriented techniques in grande applications: a method-level analysis

In this work we seek to provide a foundation for the study of the level of use of object-oriented techniques in Java programs in general, and scientific applications in particular. Specifically, we focus on the use of small methods, and the frequency with which they are called, since this forms the basis for the study of method inlining, an important optimisation technique. We compare the Grande and SPEC benchmark suites, and note a significant difference in the nature and composition of these suites

Approaching ‘kit-type’ labelling with 68Ga: the DATA chelators

The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of 68Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators—DATAM, DATAP, DATAPh, and DATAPPh—with 68Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using 68Ga positron emission tomography (PET)

The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs

Pacman/Xrn1 is a highly conserved exoribonuclease known to play a critical role in gene regulatory events such as control of mRNA stability, RNA interference and regulation via miRNAs. Although Pacman has been well studied in Drosophila tissue culture cells, the biologically relevant cellular pathways controlled by Pacman in natural tissues are unknown. This study shows that a hypomorphic mutation in pacman (pcm5) results in smaller wing imaginal discs. These tissues, found in the larva, are known to grow and differentiate to form wing and thorax structures in the adult fly. Using microarray analysis, followed by quantitative RT-PCR, we show that eight mRNAs were increased in level by >2 fold in the pcm5 mutant wing discs compared to the control. The levels of pre mRNAs were tested for five of these mRNAs; four did not increase in the pcm5 mutant, showing that they are regulated at the post-transcriptional level and therefore could be directly affected by Pacman. These transcripts include one that encodes the heat-shock protein Hsp67Bc, which is upregulated 11.9-fold at the post-transcriptional level and 2.3-fold at the protein level. One miRNA, miR-277-3p, is 5.6-fold downregulated at the post-transcriptional level in mutant discs, suggesting that Pacman affects its processing in this tissue. Together, these data show that a relatively small number of mRNAs and miRNAs substantially change in abundance in pacman mutant wing imaginal discs. Since Hsp67Bc is known to regulate autophagy and protein synthesis, it is possible that Pacman may control the growth of wing imaginal discs by regulating these processes