Differential treatment of bipolar disorder with old and new antiepileptic drugs

Although lithium remains the preferred medication for bipolar disorders, new investigations suggest that only 60 to 80% of patients have a good response with a classical presentation. The antiepileptics carbamazepine and valproate are important alternatives. Several studies have shown that lithium, carbamazepine and valproate are effective in pure mania. Mixed mania and rapid cycling respond, however, well to valproate. One disadvantage of carbamazepine is its enzyme inducing property with the consequence of a decrease of plasma levels of other psychotropic medications and a worsening of psychopathology. First data indicate a good antimanic and antidepressive efficacy of the new antiepileptic drug lamotrigine

Real-time atmospheric absorption spectra for in-flight tuning of an airborne dial system

Real-time measurements of atmospheric absorption spectra are displayed and used to precisely calibrate and fix the frequency of an Alexandrite laser to specific oxygen absorption features for airborne Differential Absorption Lidar (DIAL) measurements of atmospheric pressure and temperature. The DIAL system used contains two narrowband tunable Alexandrite lasers: one is electronically scanned to tune to oxygen absorption features for on-line signals while the second is used to obtain off-line (nonabsorbed) atmospheric return signals. The lidar operator may select the number of shots to be averaged, the altitude, and altitude interval over which the signals are averaged using single key stroke commands. The operator also determines exactly which oxygen absorption lines are scanned by comparing the line spacings and relative strengths with known line parameters, thus calibrating the laser wavelength readout. The system was used successfully to measure the atmospheric pressure profile on the first flights of this lidar, November 20, and December 9, 1985, aboard the NASA Wallops Electra aircraft

Airborne Lidar measurements of the atmospheric pressure profile with tunable Alexandrite lasers

The first remote measurements of the atmospheric pressure profile made from an airborne platform are described. The measurements utilize a differential absorption lidar and tunable solid state Alexandrite lasers. The pressure measurement technique uses a high resolution oxygen A band where the absorption is highly pressure sensitive due to collision broadening. Absorption troughs and regions of minimum absorption were used between pairs of stongly absorption lines for these measurements. The trough technique allows the measurement to be greatly desensitized to the effects of laser frequency instabilities. The lidar system was set up to measure pressure with the on-line laser tuned to the absorption trough at 13147.3/cm and with the reference laser tuned to a nonabsorbing frequency near 13170.0/cm. The lidar signal returns were sampled with a 200 range gate (30 vertical resoltion) and averaged over 100 shots

The impact of confirmed coronavirus disease 2019 (COVID-19) infection on ambulatory procedures and associated delays in care for asymptomatic patients

© 2021 Elsevier Inc. Background: Since the reopening of ambulatory centers, minimal data has been reported regarding positive tests among patients undergoing ambulatory procedures, associated delays in care, and outcomes of patients previously positive for coronavirus disease 2019. Methods: A retrospective observational case series of ambulatory procedures was performed. Records since the reopening of ambulatory centers in New York were searched for patients with positive coronavirus disease 2019 nasal swab results who underwent ambulatory procedures. Chart reviews were conducted to determine coronavirus disease history and hospitalizations, demographic information, procedure details, and 30-day admissions. Results: A total of 3,762 patients underwent ambulatory procedures. Of those, 53 were previously diagnosed with coronavirus disease 2019 but recovered and tested negative at preprocedural testing. Of the 3,709 asymptomatic patients, 37 (1.00%) tested positive during preprocedural testing; 21 patients had their procedures delayed on average 28.6 days until testing negative, while 16 had their procedures performed before testing negative owing to the time sensitivity of the procedure. There were no major complications or 30-day admissions in any of these asymptomatic patients. Three patients tested positive for coronavirus disease after having an ambulatory procedure. Conclusion: Positive tests in asymptomatic patients led to procedure delays of 28.6 days. No patients who underwent ambulatory procedures after a positive coronavirus disease 2019 test had any coronavirus disease-related complications, regardless of whether or not the procedure was delayed until testing negative. Three patients tested positive for coronavirus disease 2019 after having an ambulatory procedure; however, at an average of 19.7 days after, these cases were likely community acquired making the rate of nosocomial infection negligible

Measurement of the 18Ne(a,p_0)21Na reaction cross section in the burning energy region for X-ray bursts

The 18Ne(a,p)21Na reaction provides one of the main HCNO-breakout routes into the rp-process in X-ray bursts. The 18Ne(a,p_0)21Na reaction cross section has been determined for the first time in the Gamow energy region for peak temperatures T=2GK by measuring its time-reversal reaction 21Na(p,a)18Ne in inverse kinematics. The astrophysical rate for ground-state to ground-state transitions was found to be a factor of 2 lower than Hauser-Feshbach theoretical predictions. Our reduced rate will affect the physical conditions under which breakout from the HCNO cycles occurs via the 18Ne(a,p)21Na reaction.Comment: 5 pages, 3 figures, accepted for publication on Physical Review Letter

Archeological Of The Proposed FM 1626 Pass-Through Toll Project From Ranch-To-Market 967 To Farm-To-Market 2770 In Hays County, Texas

Hicks & Company archeologists conducted an intensive, 100-percent linear archeological survey of approximately 3.3 miles of proposed expansions to Farm-to-Market (FM) 1626 west of the city of Buda, Hays County, Texas. The survey was conducted between July 2008 and October 2016 for compliance with the Antiquities Code of Texas and Section 106 of the National Historic Preservation Act on behalf of Hays County, the project engineer Klotz Associates, and the Texas Department of Transportation (TxDOT). The Area of Potential Effects (APE) for the proposed project is composed of 54.3 acres of existing right of way and 8.08 acres of proposed expanded right of way (measuring 62.38 acres of existing plus proposed expanded right of way), and approximately 1.07 acres of temporary construction easements located outside of the existing or proposed right of way. While the proposed expanded right of way corridor has been determined, the project engineer requested that a 200-foot-wide corridor be investigated (extending 100 feet in either direction from the existing centerline) to allow for flexibility in road design, potential utility relocation, and other possible areas of concern, resulting in a total of approximately 81 acres of land surveyed. Investigations were coordinated with the Texas Historical Commission through TxDOT under Texas Antiquities Committee Permit Number 4981. On three occasions between July 28, 2008, and August 10, 2009 Hicks & Company archeologists conducted an intensive linear archeological survey of the proposed FM 1626 improvements project west of the city of Buda, Texas, on behalf of Hays County and TxDOT, returning to the field on January 21, 2016 to survey for proposed temporary construction easements located outside of the existing right of way or proposed new right of way, and again on October 26, 2016 to survey proposed new right of way in previously inaccessible parcels, completing the survey. The survey consisted of pedestrian inspection supplemented by shovel testing (N=102) and mechanical backhoe trench excavations (N=7) in the area north of Onion Creek. One backhoe trench excavated on the north bank of Onion Creek was positive for two pieces of lithic debitage, along with 32 shovel tests throughout the APE that were positive for cultural materials. One previously unrecorded site (Site 41HY449) was documented during the survey. This prehistoric surficial scatter does not meet the significance criteria for listing on the National Register of Historic Places (NRHP) or as a State Antiquities Landmark (SAL). In addition to this newly recorded site, archeologists visited elements of seven previously recorded sites (Sites 41HY199-202, 41HY209-210, and 41HY219) within the APE. Elements of one of these, Site 41HY200, could not be found within the archeological APE. Of these, only elements of Site 41HY201 are considered to have potential to deem the site eligible for inclusion on the NRHP or for designation as an SAL. The project engineer has altered plans in the vicinity of the site to avoid impacts to those resources. All other sites were found to be heavily disturbed, no longer extant, or within shallow surficial contexts atop bedrock with limited research value. Archeologists also visited the expansion areas adjacent to historic Barton Cemetery. Although the cemetery lies in close proximity to the APE, the County proposes no expansions in the immediate vicinity of the cemetery beyond a proposed retaining wall with riprap slope within the existing right of way outside the cemetery. This retaining wall is to be constructed approximately ten feet within current existing right of way. By design, retaining walls planned for this project will be fixed in place to concrete leveling pads set in place on top of the current grade and supported by earth reinforcement buildup of imported fill material. During survey, an overgrown road or trail that follows the current cemetery fenceline reinforces the assumption that the existing cemetery boundary served as the historic boundary as well, significantly reducing the potential for unmarked burials to be located within the current archeological APE. Construction within the APE is recommended to proceed with no further cultural resources investigation. The current investigations followed a no-collection policy. All projectrelated records, forms, and photographs will be permanently housed at the Texas Archeological Research Laboratory in Austin, Texas

1881 Proceedings of the Ecumenical Methodist Conference

https://place.asburyseminary.edu/wmcproceedings/1007/thumbnail.jp

Lifetimes of states in 19Ne above the 15 O + alpha breakup threshold

The 15O(alpha,gamma)19Ne reaction plays a role in the ignition of Type I x-ray bursts on accreting neutron stars. The lifetimes of states in 19Ne above the 15O + alpha threshold of 3.53 MeV are important inputs to calculations of the astrophysical reaction rate. These levels in 19Ne were populated in the 3He(20Ne,alpha)19Ne reaction at a 20Ne beam energy of 34 MeV. The lifetimes of six states above the threshold were measured with the Doppler shift attenuation method (DSAM). The present measurements agree with previous determinations of the lifetimes of these states and in some cases are considerably more precise

Molecular characterization of signalling pathways in cancer stem cells

To avoid artefacts introduced by culturing cells for extended periods of time, it is crucial to use low-passage patient-derived tumour cells. The ability to enrich, isolate and assay sub-populations of cells that behave as cancer stem cells (CSCs) from these primary cell lines is essential before performing characterizations such as gene-expression profiling. We have isolated cells from glioblastomas which show characteristics of CSCs. Although glioblastomas contain only a relatively small amount of putative CSCs, these cells express many genes which seem to be worthy targets for future therapies