Evaluasi Pelaksanaan Program Pemberdayaan Desa (Ppd) melalui Usaha Ekonomi Kelurahan Simpan Pinjam (Uek-sp) di Kelurahan Bukit Kayu Kapur Kota Dumai Tahun 2012

The research given title Evaluation Impplementation of The Program economic Enterprises Village saving and Loans (UEK/SP) at Bukit Raya Kapur Village, Dumai City in 2012. Its behind of this research is srill a using funds loans not used according to plan the proposal loan lack of aweareness of the public in paying the mortgage in adition its still a lot of people who do not in the criteria for low-icome communities also enjoy this program and number of delinquent loans is higher as well the list of loans that are pilling up.The aim of research is evaluation implementation of the program economic enterprises village saving and loans (UEK-SP) at Bukit Raya Kapur Village Dumai City in 2012. The usefulness of this research is as input agencies in an effort to take out policy in the future. Types and method of research is descriptive research, which can be defined as program solving or describe investigated by describing the state of the subject and object of research based on the facts that seem or how their. While the method used qualitative research method to describe the actual situation and the actual detail by looking at the problem and research objectives determined purposive based withdrawal nonprobability sample properties. Data was collected by interview and documentation.The research that concludes evaluation implementation of program economic enterprises village saving and loans (UEK/SP) at Bukit Raya Kapur Village Dumai City in 2012 its Not Good. Where implementation of the TUPOKSI by UEK/SP has not been done well, so that people who received benefits from this program is not accuarate and this is also due to the implementation of the verification that is not in accordance with existing guidelines so that the level of arrears communities become higher. Arrears by using so the roll can not be done every single month and also resulted in the list of loans the are pilling up. Futhermore, the absorption of funds which have not been up to touch the law-income communities that lack of venture capital.The Key Word : Evaluation, Program, PPD, UEK/S

Response of arbuscular mycorrhizal mungbean plants to ambient air pollution

The experiments were conducted in open top chamber system installed at the University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan. The mungbean ( Vigna radiata (L.) Wilczek var.M28) seeds were sown in earthen pots and were kept in filtered air, unfiltered air and ambient air. The ozone concentration was monitored daily during 1000hrs till 1600 h. The data for light intensity and relative humidity was also regularly collected. The sets of plants growing in FA chambers (without ozone and dust particles) responded well as regards growth and yields are concerned. Unfiltered air reduced the number of nodules, their biomass and nitroginase activity in mungbean plants. The present study documents that the species of mycorrhizal fungi sensitive to tropospheric ozone failed to reproduce in ambient air and unfiltered air chambers (without dust particles). Out of a total of 24 species, eighteen species belonged to the genus Glomus, two each to Sclerocystis, to Acaulospora and one each to Gigaspora and Scutellospora. The total number of species was variable during the growth phase. The total number of species reduced in soil of UFA chambers with the passage of time. Species richness reduced to almost half in UFA plants as compared to FA plants. Species of the Genus Glomus were highly abundant species at various harvests in all air treatments. Amongst most abundantly recovered Glomus species were G. fasciculatum, G. mosseae, G. aggregatum, G. caledonicum, G. deserticola, G. geosporum, and G. monosporum. The pattern of abundance kept on varying at various harvests for different air and mycorrhizal treatments. In the case of plants of UFA treatment, only two species of Glomus were abundant namely G. fasciculatum and G. geosporum. Species of Acaulospora and Gigaspora in particular and Scutellospora and Sclerocystis in general were sensitive to polluted air

Therapeutics discovery: From bench to first in-human trials

The ‘Therapeutics discovery: From bench to first in-human trials’ conference, held at the King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), Kingdom of Saudi Arabia (KSA) from October 10-12, 2017, provided a unique opportunity for experts worldwide to discuss advances in drug discovery and development, focusing on phase I clinical trials. It was the first event of its kind to be hosted at the new research center, which was constructed to boost drug discovery and development in the KSA in collaboration with institutions, such as the Academic Drug Discovery Consortium in the United States of America (USA), Structural Genomics Consortium of the University of Oxford in the United Kingdom (UK), and Institute of Materia Medica of the Chinese Academy of Medical Sciences in China. The program was divided into two parts. A pre‑symposium day took place on October 10, during which courses were conducted on clinical trials, preclinical drug discovery, molecular biology and nanofiber research. The attendees had the opportunity for one-to-one meetings with international experts to exchange information and foster collaborations. In the second part of the conference, which took place on October 11 and 12, the clinical trials pipeline, design and recruitment of volunteers, and economic impact of clinical trials were discussed. The Saudi Food and Drug Administration presented the regulations governing clinical trials in the KSA. The process of preclinical drug discovery from small molecules, cellular and immunologic therapies, and approaches to identifying new targets were also presented. The recommendation of the conference was that researchers in the KSA must invest more fund, talents and infrastructure to lead the region in phase I clinical trials and preclinical drug discovery. Diseases affecting the local population, such as Middle East Respiratory Syndrome and resistant bacterial infections, represent the optimal starting point

Blocking FSH induces thermogenic adipose tissue and reduces body fat.

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis