16 research outputs found

    Progressing emergent constraints on future climate change

    Get PDF
    In recent years, an evaluation technique for Earth System Models (ESMs) has arisen—emergent constraints (ECs)—which rely on strong statistical relationships between aspects of current climate and future change across an ESM ensemble. Combining the EC relationship with observations could reduce uncertainty surrounding future change. Here, we articulate a framework to assess ECs, and provide indicators whereby a proposed EC may move from a strong statistical relationship to confirmation. The primary indicators are verified mechanisms and out-of-sample testing. Confirmed ECs have the potential to improve ESMs by focusing attention on the variables most relevant to climate projections. Looking forward, there may be undiscovered ECs for extremes and teleconnections, and ECs may help identify climate system tipping points

    Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.

    Get PDF
    Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness
    corecore