Factors Affecting the Radioimmunological Determination of Carcinoembryonic Antigen in Human Plasma

Peer Reviewe

Bifurcation Routes to Volatility Clustering under Evolutionary Learning

A simple asset pricing model with two types of boundedly rational traders, fundamentalists and chartists, is studied. Fractions of trader types change over time according to evolutionary learning, with chartists conditioning their forecasting rule upon deviations from a benchmark fundamental. Volatility clustering arises endogenously and two generic mechanisms are proposed as an explanation: (1) coexistence of a stable steady state and a stable limit cycle, due to a so-called Chenciner bifurcation of the system and (2) intermittency and associated bifurcation routes to strange attractors. Economic intuition as to why these phenomena arise in nonlinear multi-agent evolutionary systems is provided

Experimental evidence of differences in the absorption spectra of clustered and isolated ions in erbium doped fibers

The absorption spectra of clustered and isolated ions in erbium-doped germanosilicate fibers have been experimentally studied. The ground state absorption spectra broaden as the degree of erbium-ion clustering increases, indicating that the absorption spectra of clustered ions is significantly different from that of the homogeneous ions. This is confirmed by comparing the broadened absorption spectra with the fibre unbleachable loss spectrum; a direct measurement of the clustered ions. This is the first experimental evidence indicating different absorption cross-sections for the two species of ions in germanosilicate glass, an assumption used in the theoretical description of self-pulsing in erbium doped fiber lasers, but in direct contradiction to the pair-induced quenching model widely used to characterise EDFAs

Hepatitis C virus genotypes in liver transplant recipients: Impact on posttransplant recurrence, infections, response to interferon-α therapy and outcome

Background. End-stage liver disease due to hepatitis C virus (HCV) is the most common indication for liver transplantation in U.S. veterans. We investigated the influence of HCV genotypes on the incidence and timing of recurrent HCV hepatitis, survival, infectious morbidity, and response to interferon-α therapy in this unique patient population. Methods. HCV genotype was determined by direct sequencing of the NS5 region of HCV with type-specific primers. Results. Genotype 1a (66%, 32/47) was the predominant genotype. Type 1b was found in 25% (12/47) of patients and type 2b was found in 9% (4/47). His topathologically recurrent HCV hepatitis developed in 53% (25/47) of the patients after transplantation. This group included 45% (14/31) of the patients with type 1a, 67% (8/12) of the patients with type 1b, and 25% (1/4) of the patients with type 2b (P>0.5). The time to recurrence and the severity of HCV recurrence as defined by aminotransferase levels or Knodell scores were not different among the three genotypes. There was a trend toward a higher incidence of major infections in patients with type 1b (75%) versus type 1a (48%) and type 2b (50%) (P=0.11). The response to interferon-α therapy did not differ significantly among the genotypes. Mortality at 5 years was 16% (5/31) in patients with genotype 1a, 42% (5/12) in patients with genotype 1b, and 50% (2/4) in patients with genotype 2b (P=0.06). Conclusions. The incidence, time to recurrence, and response to interferon-α therapy did not differ be tween the various genotypes in our liver transplant recipients. However, there was a trend toward higher infectious morbidity and overall mortality in patients with genotype 1b after transplantation

Normal-internal resonances in quasi-periodically forced oscillators: a conservative approach

We perform a bifurcation analysis of normal–internal resonances in parametrised families of quasi–periodically forced Hamiltonian oscillators, for small forcing. The unforced system is a one degree of freedom oscillator, called the ‘backbone’ system; forced, the system is a skew–product flow with a quasi–periodic driving with basic frequencies. The dynamics of the forced system are simplified by averaging over the orbits of a linearisation of the unforced system. The averaged system turns out to have the same structure as in the well–known case of periodic forcing ; for a real analytic system, the non–integrable part can even be made exponentially small in the forcing strength. We investigate the persistence and the bifurcations of quasi–periodic –dimensional tori in the averaged system, filling normal–internal resonance ‘gaps’ that had been excluded in previous analyses. However, these gaps cannot completely be filled up: secondary resonance gaps appear, to which the averaging analysis can be applied again. This phenomenon of ‘gaps within gaps’ makes the quasi–periodic case more complicated than the periodic case