STABILIZATION FOR THE TRANSMISSION PROBLEM OF THE TIMOSHENKO SYSTEM IN THERMOELASTICITY WITH TWO CONCENTRATED MASSES

In this paper, our main goal is to study the stability of the ther-moelastic Timoshenko beam with locally distributed temperature. Then, we consider the transmission problem of the Timoshenko system in thermoelas-ticity with two concentrated masses. We show the non-exponential stability by using a result introduced by J. E. Muñoz Rivera and R. Racke [18] based on the Weyl theorem. Otherwise, we prove the polynomial stability by using a frequency domain method

The Impact of the Strategic Orientations on Crisis Management Agency, International Relief in Gaza

The research aims to identify the impact of the strategic orientations (Vision, Mission, goals) on crisis management agency, international relief in Gaza, the researchers used the descriptive and analytical approach and a survey for collection data, amounted to community size (881), and the study sample (268), and the sample was a stratified random. SPSS program used for entry, processing and analysis of data. The most important findings of the study: The results showed that the organization develop a clearly written vision, mission and strategic goals and the organization's strategic objectives are consistent with the vision and mission of the organization. The results also showed that the organization develop a clear stage objectives framed with time bass which can be achieved on the ground. The employees in the organization's behavior comes within a disciplined set of principles and values that underpin the organization. Also the concept of the organization vision and mission are familiar for the employees. In general the views of the research sample agreed that there is a presence of strategic orientations (vision, message, goals). A direct positive correlation between the presence of strategic orientations (vision, mission and goals) and crisis management (before, during and after the crisis) in the international relief agency in Gaza. The research also concluded a series of recommendations, Researchers consistently recommend the continuous existence of strategic orientation and continue to develop the vision, mission and objectives in a clearly written method. In addition to that, the organization must develop in advance plans to deal with crises, taking into account past experience in this field through a specialized team, hold continuous meetings and discussions and workshops with the emergency team who has previous experience in dealing with crises

Classifying Deformable and Non-deformable Video Objects

This paper presents a fully automated approach to classifying deformable and non-deformable moving objects in a video surveillance scene. We estimate an object's motion using Marzat optical-flow algorithm. We filter the motion vectors and attempt to find the transformation that represents the correct mapping between the two positions. The Fundamental transformation is estimated using the Normalized Eight-Point Algorithm. We introduce a new type of graph to set the thresholds between deformable and non-deformable motion. Furthermore, we use temporal consistency to classify deformable and non-deformable objects. For experiments, we used a varied corpus of real surveillance videos. Our proposed approach for motion classification achieved a precision rate of 92 percent

Antisense oligonucleotide inhibition of hepatitis C virus genotype 4 replication in HepG2 cells

BACKGROUND: Hepatitis C (HCV) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy. It is estimated that over 15% of Egyptians are infected by the virus and thus finding a cure for this disease is of utmost importance. Current therapies for hepatitis C virus (HCV) genotype 4 with interferon/ribavirin have not been successful and thus the development of alternative therapy for this genotype is disparately needed. RESULTS: Although previous studies utilizing viral subgenomic or full cDNA fragments linked to reporter genes transfected into adhered cells or in a cell free system showed promise, demonstration of efficient viral replication was lacking. Thus, we utilized HepG2 cells infected with native HCV RNA genomes in a replication competent system and used antisense phosphorothioate Oligonucleotides (S-ODN) against stem loop IIId and the AUG translation start site of the viral polyprotein precursor to monitor viral replication. We were able to show complete arrest of intracellular replication of HCV-4 at 1 uM S-ODN, thus providing a proof of concept for the potential antiviral activity of S-ODN on native genomic replication of HCV genotype 4. CONCLUSION: We have successfully demonstrated that by using two S-ODNs [(S-ODN1 (nt 326–348) and S-ODN-2 (nt 264–282)], we were able to completely inhibit viral replication in culture, thus confirming earlier reports on subgenomic constructs and suggesting a potential therapeutic value in HCV type 4

Pharaonic necrostratigraphy : a review of geological and archaeological studies in the Theban Necropolis, Luxor, West Bank, Egypt

Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Terra Nova 21 (2009): 237-256, doi:10.1111/j.1365-3121.2009.00872.x.We present a review of archeological and geological studies on the West Bank as a basis for discussing the geological setting of the tombs and geologically related problems with a view to providing archeologists with a framework in which to conduct their investigations on the restoration, preservation and management of the antique monuments. Whereas the geology of the Upper Nile Valley appears to be deceptively simple, the lithologic succession is vertically variable, and we have recognized and defined several new lithologic units within the upper Esna Shale Formation. We have been able to delineate lithologic (shale/limestone) contacts in several tombs and observed that the main chambers in some were excavated below the Esna Shale in the Tarawan Chalk Formation. We have been able to document changing dip in the strata (warping) in several tombs, and to delineate two major orientations of fractures in the field. Investigations behind the Temple of Hatshepsut, in the Valley of the Kings and around Deir El Medina, have revealed four broad regional structures. We confirm that the hills located near the Nile Valley, such as Sheik Abel Qurna, do not belong to the tabular structure of the Theban Mountain, but are discrete displaced blocks of the Thebes Limestone and overlying El Miniya, as supported by Google Earth photographs

Effect of water flow rate on quantity and quality of lettuce (Lactuca sativa L.) in nutrient film technique (NFT) under hydroponics conditions

In the study of hydroponics, questions have risen concerning about ideal water flow that allow the plant to absorbing highest amount of nutrient from the nutrient solution during irrigating process. Thus, this experiment was aimed to determine the ideal water flow rate in nutrient film technique system in order to optimize the nutrients uptake with growth of lettuce. Different flow rates 10, 20 and 30 L/hour were assigned as T1, T2 and T3, respectively, with lettuce plants and the space between plants 15 cm. Generally, the growth decreased significantly with increasing in water flow rate. The analysis of lettuce hydroponics variable reveals that flow rate at 20 L/hour provides higher mean rank rather than other flow rate 10 L/hour and 30 L/hour. The findings of this research stated that if flow rate is increased to 30 L/hour plant height, number of leaves, number of outer and inner leaves, heat mass and stem mass decreases. On the whole from the analysis it is concluded that for flow rate 20 L/hour enhances the growth rate of lettuce in hydroponics hence it is stated that flow rate of 20 L/hour is good flow rate rather than 10 L/hour and 30 L/hour. Water flow in nutrient film technique is essential to be ideal through allow the plants root to absorb all elements needed form nutrient solutions in hydroponics system. And thus, water movement in the system and the rate of turnover should be designed to ensure good contact time for roots and water flow in the system

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice

Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution. One suggested strategy for treating tauopathy is to stimulate autophagy, hence, getting rid of these pathological protein aggregates. One key controller of autophagy is mTOR. Since stimulation of mTOR leads to inhibition of autophagy, inhibitors of mTOR will cause stimulation of autophagy process. In this report, tauopathy was induced in mice using annonacin. Blocking of mTOR was achieved through stereotaxic injection of siRNA against mTOR. The behavioral and immunohistochemical evaluation revealed the development of tauopathy model as proven by deterioration of behavioral performance in open field test and significant tau aggregates in annonacin-treated mice. Blocking of mTOR revealed significant clearance of tau aggregates in the injected side; however, tau expression was not affected by mTOR blockage

The natural history of primary sclerosing cholangitis in 781 children. A multicenter, international collaboration

There are limited data on the natural history of primary sclerosing cholangitis (PSC) in children. We aimed to describe the disease characteristics and long-term outcomes of pediatric PSC. We retrospectively collected all pediatric PSC cases from 36 participating institutions and conducted a survival analysis from the date of PSC diagnosis to dates of diagnosis of portal hypertensive or biliary complications, cholangiocarcinoma, liver transplantation, or death. We analyzed patients grouped by disease phenotype and laboratory studies at diagnosis to identify objective predictors of long-term outcome. We identified 781 patients, median age 12 years, with 4,277 person-years of follow-up; 33% with autoimmune hepatitis, 76% with inflammatory bowel disease, and 13% with small duct PSC. Portal hypertensive and biliary complications developed in 38% and 25%, respectively, after 10 years of disease. Once these complications developed, median survival with native liver was 2.8 and 3.5 years, respectively. Cholangiocarcinoma occurred in 1%. Overall event-free survival was 70% at 5 years and 53% at 10 years. Patient groups with the most elevated total bilirubin, gamma-glutamyltransferase, and aspartate aminotransferase-to-platelet ratio index at diagnosis had the worst outcomes. In multivariate analysis PSC-inflammatory bowel disease and small duct phenotypes were associated with favorable prognosis (hazard ratios 0.6, 95% confidence interval 0.5-0.9, and 0.7, 95% confidence interval 0.5-0.96, respectively). Age, gender, and autoimmune hepatitis overlap did not impact long-term outcome. CONCLUSION: PSC has a chronic, progressive course in children, and nearly half of patients develop an adverse liver outcome after 10 years of disease; elevations in bilirubin, gamma-glutamyltransferase, and aspartate aminotransferase-to-platelet ratio index at diagnosis can identify patients at highest risk; small duct PSC and PSC-inflammatory bowel disease are more favorable disease phenotypes