CHAERUL SALEH DALAM MEMPERJUANGKAN, MENGISI, DAN MEMPERTAHANKAN KEMERDEKAAN INDONESIA

Abstrak                 Chaerul Saleh Datuk Paduko Rajo atau lebih dikenal dengan nama Chaerul Saleh sebagai mahasiswa hukum mulai aktif dalam kegiatan pemuda. Golongan pemuda yang aktif mulai bergabung dengan gerakan pemuda dari asrama Menteng Raya 31 seperti Chaerul Saleh, Sukarni, A.M. Hanafi, dan Ismail. Chaerul Saleh menonjol dan menunjukkan pandangan perjuangannya bersifat nasionalis. Peristiwa Rengasdengklok menjadi awal perjuangan percepatan kemerdekaan Indonesia yang dipelopori oleh Chaerul Saleh, Wikana dan beberapa pemuda lainnya. Peran Chaerul Saleh, menjadi sangat menarik pada awal proklamasi kemerdekaan Republik Indonesia, karena Chaerul Saleh berperan penting dalam mewarnai perjuangan kemerdekaan Indonesia. Chaerul Saleh merupakan salah seorang tokoh pejuang yang memiliki peran dan ikut mewarnai perjalanan sejarah Indonesia menjelang proklamasi sampai masa akhir pemerintah orde lama. Pada tanggal 1-23 agustus 1944 untuk pertama kali tokoh pemuda Chaerul Saleh beserta kawan-kawan mewakili peran pemuda. Chaerul Saleh sebagai pemimpin pemuda berusaha mendesak agar Soekarno dan Hatta segera menyatakan kemerdekaan Indonesia. Awal pergerakan perhimpunan Indonesia Chaerul Saleh merupakan orang kepercayaan Soekarno yang paling dekat sehingga masuk dalam cabinet menjadi menteri urusan veteran.   Kata Kunci : Chaerul Saleh, gerakan pemud

Computational and Mathematical Modelling of the EGF Receptor System

This chapter gives an overview of computational and mathematical modelling of the EGF receptor system. It begins with a survey of motivations for producing such models, then describes the main approaches that are taken to carrying out such modelling, viz. differential equations and individual-based modelling. Finally, a number of projects that applying modelling and simulation techniques to various aspects of the EGF receptor system are described

Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domain.

Binding of antigen to the B cell receptor (BCR) induces conformational changes in BCR's cytoplasmic domains that are concomitant with phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs). Recently, reversible folding of the CD3ε and ξ chain ITAMs into the plasma membrane has been suggested to regulate T cell receptor signaling. Here we show that the Igα and Igβ cytoplasmic domains of the BCR do not associate with plasma membrane in resting B cells. However, antigen binding and ITAM phosphorylation specifically increased membrane proximity of Igα, but not Igβ. Thus, BCR activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igα and Igβ to differently localized signaling complexes

Stoichiometry of HLA Class II-Invariant Chain Oligomers

BACKGROUND: The HLA gene complex encodes three class II isotypes, DR, DQ, and DP. HLA class II molecules are peptide receptors that present antigens for recognition by T lymphocytes. In antigen presenting cells, the assembly of matched α and β subunits to heterodimers is chaperoned by invariant chain (Ii). Ii forms a homotrimer with three binding sites for class II heterodimers. The current model of class II and Ii structure states that three αβ heterodimers bind to an Ii trimer. METHODOLOGY/PRINCIPAL FINDINGS: [corrected] We have now analyzed the composition and size of the complexes of class II and Ii using epitope tagged class II subunits and density gradient experiments. We show here that class II-Ii oligomers consist of one class II heterodimer associated with one Ii trimer, such that the DR, DQ and DP isotypes are contained within separate complexes with Ii. CONCLUSION/SIGNIFICANCE: We propose a structural model of the class II-Ii oligomer and speculate that the pentameric class II-Ii complex is bent towards the cell membrane, inhibiting the binding of additional class II heterodimers to Ii

Transparent Meta-Analysis of Prospective Memory and Aging

Prospective memory (ProM) refers to our ability to become aware of a previously formed plan at the right time and place. After two decades of research on prospective memory and aging, narrative reviews and summaries have arrived at widely different conclusions. One view is that prospective memory shows large age declines, larger than age declines on retrospective memory (RetM). Another view is that prospective memory is an exception to age declines and remains invariant across the adult lifespan. The present meta-analysis of over twenty years of research settles this controversy. It shows that prospective memory declines with aging and that the magnitude of age decline varies by prospective memory subdomain (vigilance, prospective memory proper, habitual prospective memory) as well as test setting (laboratory, natural). Moreover, this meta-analysis demonstrates that previous claims of no age declines in prospective memory are artifacts of methodological and conceptual issues afflicting prior research including widespread ceiling effects, low statistical power, age confounds, and failure to distinguish between various subdomains of prospective memory (e.g., vigilance and prospective memory proper)

A many-analysts approach to the relation between religiosity and well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β=0.120). For the second research question, this was the case for 65% of the teams (median reported β=0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

Air Transport Research Society

The Automated People Mover (APM) is an important asset for many airports to transport passengers inside or between terminal and satellite buildings An APM system normally runs on fixed schedules throughout the day, which means that the capacity of the APM is pre-determined and not depending on the actual demand. This at times can cause either an overcapacity, which leads to a waste of resources, or an under capacity, which results in passengers waiting at the station. Especially the latter factor is problematic, as it reduced passenger experience and can negatively affect the transfer process between airport facilities. In order to better match the offered APM capacity with the demand, it is proposed in this paper to use sensor-based predictive control system, which adapts the APM system capacity to real-time demand. By means of sensor data, passenger numbers are determined before they walk onto the stations platforms, and subsequently the APM system capacity is adjusted to the measured demand. In principle there are two methods to change the APM system capacity, i.e.: 1) by changing the APM capacity (i.e. more cars per train) or 2) by changing the frequency. A simulation test case was designed to provide numerical insight in the potential of adaptively changing the capacity of an APM, based on sensor derived real-time demand. The test case was derived from a variety of typical systems used worldwide and represents a complex APM system. From the simulation results it is concluded that an intelligent design of the control system results in significant improvements in terms of passenger experience, operational cost, capital cost and emission footprint. The favourable method of adjusting capacity to demand is by increase train capacity, before reducing the headway between trains