Off-Street Vehicular Fog for Catering Applications in 5G/B5G: A Trust-based Task Mapping Solution and Open Research Issues

One of the key enablers in serving the applications requiring stringent latency in 5G networks is fog computing as it is situated closer to the end users. With the technological advancement of vehicles’ on-board units, their computing capabilities are becoming robust, and considering the underutilization of the off-street vehicles, we envision that the off-street vehicles can be an enormously useful computational source for the fog computing. Additionally, clustering the vehicles would be advantageous in order to improve the service availability. As the vehicles become highly connected, trust is needed especially in distributed environments. However, vehicles are made from different manufacturers, and have different platforms, security mechanisms, and varying parking duration. These lead to the unpredictable behavior of the vehicles where quantifying trust value of vehicles would be difficult. A trust-based solution is necessary for task mapping as a task has a set of properties including expected time to complete, and trust requirements that need to be met. However, the existing metrics used for trust evaluation in the vehicular fog computing such as velocity and direction are not applicable in the off-street vehicle fog environments. In this paper, we propose a framework for quantifying the trust value of off-street vehicle fog computing facilities in 5G networks and forming logical clusters of vehicles based on the trust values. This allows tasks to be shared with multiple vehicles in the same cluster that meets the tasks’ trust requirements. Further, we propose a novel task mapping algorithm to increase the vehicle resource utilization and meet the desired trust requirements while maintaining imposed latency requirements of 5G applications. Results obtained using iFogSim simulator demonstrate that the proposed solution increases vehicle resource utilization and reduces task drop noticeably. This paper presents open research issues pertaining to the study to lead..

OPTIMIZATION OF EDM SMALL HOLE DRILLING PROCESS USING TAGUCHI APPROACH

ABSTRACT Electrical Discharge Machining (EDM) is a process used to remove or cut a material into desired shape through the action of spark discharge between the tool and work piece. The objective of this paper is to optimize the independent variables to achieve better accuracy in EDM small hole drilling by using Taguchi method. The L9 orthogonal array is employed to study the performance characteristics in drilling operations of mild steel (AS3679) as workpiece by using 1 mm copper (Cu) pipe electrode. Three drilling parameters namely, pulse off time, peak current and servo standard voltage are considered to optimize drilling hole diameter. The result concluded that use of greater pulse off time, greater peak current and medium servo standard voltage give the better hole diameter for the specific test range. Further study in this topic could consider different factor such as pulse on time, material removal rate (MRR) and coolants to investigate how these factors would affect hole diameter

Functional Outcome after Treatment of Aggressive Tumours in the Distal Radius: Comparison between Reconstruction using Proximal Fibular Graft and Wrist Fusion

Introduction: Restoration of a functional hand is the ultimate goal following a distal radius tumour resection. The early outcomes of mobile wrist reconstruction are satisfactory; however, long-term results are unpredictable due to late wrist instability and degenerative arthritis. Our aim is to compare mobile wrist reconstruction with wrist fusion (pan-carpal fusion) in our cohort of patients. Materials and Methods: A retrospective cohort study was performed for functional outcomes of all patients who underwent resection for distal radius tumour and treated with either fusion or reconstruction of the wrist in a single institution from years 2000-2013 with a minimum of three years follow-up. Results: Eleven patients were included in the study, six of whom had wrist reconstruction with proximal fibula graft and the remaining five wrist fusion, with a mean follow-up of 6.3 years. The mean Musculoskeletal Tumour Society (MSTS) score was 82.78%, ranging from 70% to 93.3%. Average grip strength compared to the normal contralateral hand was 60.0% for total wrist fusion, which was better than wrist reconstruction with 58.07%. There was no difference in the functional outcome between fusion and mobile reconstruction in our study. Osteoarthritis changes and subluxation of the wrist joint were the most common findings in the long-term follow-up for this group. Conclusion: There was no difference in the functional outcome of the long-term follow-up between the two groups

Energy consumption and spatial assessment of renewable energy penetration and building energy efficiency in malaysia: A review

The development of sustainable energy systems is very important to addressing the economic, environmental, and social pressures of the energy sector. Globally, buildings consume up to 40% of the world’s total energy. By 2030, it is expected to increase to 50%. Therefore, the world is facing a great challenge to overcome these problems related to global energy production. Malaysia is one of the top consumers of primary energy in Asia. In 2018, primary energy consumption for Malaysia was 3.79 quadrillion btu at an average annual rate of 4.58%. In this paper, we have carried out a detailed literature review on several previous studies of energy consumption in the world, especially in Malaysia, and how geographical information system (GIS) methods have been used for the spatial assessment of energy efficiency. Indeed, strategies of energy efficiency are essential in energy policy that could be created using various approaches used for energy savings in buildings. The findings of this review reveal that, for estimating energy consumption, exploring renewable energy sources, and investigating solar radiation, several geographic information system techniques such as multiple criteria decision analysis (MCDA), machine learning (ML), and deep learning (DL) are mainly utilized. The result indicates that the fuzzy DS method can more reliably determine the optimal PV farm locations. The 3D models are also regarded as an effective tool for estimating solar radiation, since this method generates a 3D model exportable to software tools. In addition, GIS and 3D can contribute to several purposes, such as sunlight access to buildings in urban areas, city growth prediction models and analysis of the habitability of public places

Fangchinoline Inhibits Human Immunodeficiency Virus Type 1 Replication by Interfering with gp160 Proteolytic Processing

The introduction of highly active antiretroviral therapy has led to a significant reduction in the morbidity and mortality of acquired immunodeficiency syndrome patients. However, the emergence of drug resistance has resulted in the failure of treatments in large numbers of patients and thus necessitates the development of new classes of anti-HIV drugs. In this study, more than 200 plant-derived small-molecule compounds were evaluated in a cell-based HIV-1 antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (fangchinoline). Fangchinoline, a bisbenzylisoquinoline alkaloid isolated from Radix Stephaniae tetrandrae, exhibited antiviral activity against HIV-1 laboratory strains NL4-3, LAI and BaL in MT-4 and PM1 cells with a 50% effective concentration ranging from 0.8 to 1.7 µM. Mechanism-of-action studies showed that fangchinoline did not exhibit measurable antiviral activity in TZM-b1 cells but did inhibit the production of infectious virions in HIV-1 cDNA transfected 293T cells, which suggests that the compound targets a late event in infection cycle. Furthermore, the antiviral effect of fangchinoline seems to be HIV-1 enve1ope-dependent, as the production of infectious HIV-1 particles packaged with a heterologous envelope, the vesicular stomatitis virus G glycoprotein, was unaffected by fangchinoline. Western blot analysis of HIV envelope proteins expressed in transfected 293T cells and in isolated virions showed that fangchinoline inhibited HIV-1 gp160 processing, resulting in reduced envelope glycoprotein incorporation into nascent virions. Collectively, our results demonstrate that fangchinoline inhibits HIV-1 replication by interfering with gp160 proteolytic processing. Fangchinoline may serve as a starting point for developing a new HIV-1 therapeutic approach

Household catastrophic healthcare expenditure and impoverishment due to rotavirus gastroenteritis requiring hospitalization in Malaysia.

BACKGROUND: While healthcare costs for rotavirus gastroenteritis requiring hospitalization may be burdensome on households in Malaysia, exploration on the distribution and catastrophic impact of these expenses on households are lacking. OBJECTIVES: We assessed the economic burden, levels and distribution of catastrophic healthcare expenditure, the poverty impact on households and inequities related to healthcare payments for acute gastroenteritis requiring hospitalization in Malaysia. METHODS: A two-year prospective, hospital-based study was conducted from 2008 to 2010 in an urban (Kuala Lumpur) and rural (Kuala Terengganu) setting in Malaysia. All children under the age of 5 years admitted for acute gastroenteritis were included. Patients were screened for rotavirus and information on healthcare expenditure was obtained. RESULTS: Of the 658 stool samples collected at both centers, 248 (38%) were positive for rotavirus. Direct and indirect costs incurred were significantly higher in Kuala Lumpur compared with Kuala Terengganu (US$222 Vs. US$45; p<0.001). The mean direct and indirect costs for rotavirus gastroenteritis consisted 20% of monthly household income in Kuala Lumpur, as compared with only 5% in Kuala Terengganu. Direct medical costs paid out-of-pocket caused 141 (33%) households in Kuala Lumpur to experience catastrophic expenditure and 11 (3%) households to incur poverty. However in Kuala Terengganu, only one household (0.5%) experienced catastrophic healthcare expenditure and none were impoverished. The lowest income quintile in Kuala Lumpur was more likely to experience catastrophic payments compared to the highest quintile (87% vs 8%). The concentration index for out-of-pocket healthcare payments was closer to zero at Kuala Lumpur (0.03) than at Kuala Terengganu (0.24). CONCLUSIONS: While urban households were wealthier, healthcare expenditure due to gastroenteritis had more catastrophic and poverty impact on the urban poor. Universal rotavirus vaccination would reduce both disease burden and health inequities in Malaysia

Open-access mega-journals: A bibliometric profile

In this paper we present the first comprehensive bibliometric analysis of eleven open-access mega-journals (OAMJs). OAMJs are a relatively recent phenomenon, and have been characterised as having four key characteristics: large size; broad disciplinary scope; a GoldOA business model; and a peer-review policy that seeks to determine only the scientific soundness of the research rather than evaluate the novelty or significance of the work. Our investigation focuses on four key modes of analysis: journal outputs (the number of articles published and changes in output over time); OAMJ author characteristics (nationalities and institutional affiliations); subject areas (the disciplinary scope of OAMJs, and variations in sub-disciplinary output); and citation profiles (the citation distributions of each OAMJ, and the impact of citing journals). We found that while the total output of the eleven megajournals grew by 14.9% between 2014 and 2015, this growth is largely attributable to the increased output of Scientific Reports and Medicine. We also found substantial variation in the geographical distribution of authors. Several journals have a relatively high proportion of Chinese authors, and we suggest this may be linked to these journals’ high Journal Impact Factors (JIFs). The mega-journals were also found to vary in subject scope, with several journals publishing disproportionately high numbers of articles in certain sub-disciplines. Our citation analsysis offers support for Björk & Catani’s suggestion that OAMJs’s citation distributions can be similar to those of traditional journals, while noting considerable variation in citation rates across the eleven titles. We conclude that while the OAMJ term is useful as a means of grouping journals which share a set of key characteristics, there is no such thing as a “typical” mega-journal, and we suggest several areas for additional research that might help us better understand the current and future role of OAMJs in scholarly communication