13 research outputs found
Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia
Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study
Background: Preoperative anaemia and low exertional oxygen uptake are both associated with greater
postoperative morbidity and mortality. This study reports the association among haemoglobin concentration ([Hb]),
peak oxygen uptake (V_O2 peak) and anaerobic threshold (AT) in elective surgical patients.
Methods: Between 1999 and 2011, preoperative [Hb] and cardiopulmonary exercise tests were recorded in 1,777
preoperative patients in four hospitals. The associations between [Hb], V_O2 peak and AT were analysed by linear
regression and covariance.
Results: In 436 (24.5%) patients, [Hb] was <12 g dl-1 and, in 83 of these, <10 g dl-1. Both AT and V_O2 peak rose
modestly with increasing [Hb] (r2 = 0.24, P <0.0001 and r2 = 0.30, P <0.0001, respectively). After covariate
adjustment, an increase in [Hb] of one standard deviation was associated with a 6.7 to 9.7% increase in V_O2 peak,
and a rise of 4.4 to 6.0% in AT. Haemoglobin concentration accounted for 9% and 6% of the variation in V_O2 peak
and AT respectively.
Conclusions: To a modest extent, lower haemoglobin concentrations are independently associated with lower
oxygen uptake during preoperative cardiopulmonary exercise testing. It is unknown whether this association is
causative