Stabilization of biped dynamic walking using gyroscopic couple

This paper presents a new strategy for dynamic walking where a gyroscope mounted on top of the biped is precessed to achieve balancing both in the Coronal and Sagittal planes. A gait is devised and simulation results are provided to show the feasibility of proposed balancing method.published_or_final_versio

Machine requirements planning and workload assignment using genetic algorithms

This paper presents a genetic approach to determining the optimal number of machines required in a manufacturing system for meeting a specified production schedule. This use of genetic algorithms is illustrated by solving a typical machine requirements planning problem. Comparison of the respective results obtained by using the proposed approach and a standard mixed-integer programming package shows that the proposed approach is indeed an effective means for optimal manufacturing systems design.published_or_final_versio

An integrative bioinformatic approach for identifying subtypes and subtype-specific drivers in cancer

Cancer is a complex disease and within a cancer, subtypes of patients with distinct behaviors often exist. The subtypes might have been caused by different hits, such as copy number aberrations (CNAs) and point mutations, on different pathways/cells-of-origin in a common tissue/organ. Identifying the subtypes with subtype-specific drivers, i.e., hits, is key to the understanding of cancer and development of novel treatments. Here, we report the development of an integrative method to identify the subtypes of cancer. Specifically, we consider CNAs and their impact on gene expressions. Based on these relations, we propose an iterative approach that alternates between kernel based gene expression clustering and gene signature selection. We applied the method to datasets of the pediatric cancer medulloblastoma (MB). The consensus number of clusters quickly converges to three; and for each of these three subtypes, the signature detection also converges to a consistent set of a few hundred highly functionally related genes. For each of the subtypes, we correlate its signature with the set of within-subtype recurrent CNA-affected genes for identifying drivers. The top-ranked driver candidates are found to be enriched with known pathways in certain subtypes of MB as well as containing novel genes that might reveal new understandings for other subtypes.published_or_final_versionThe 2012 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB’12), San Diego, CA., 9-12 May 2012. In IEEE CIBCB Proceedings, 2012, p. 169-17

Electronic transitions of platinum monoboride

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Expression of chondroitin sulfotransferase in cranial motor neurons for cell migration in rat embryonic hindbrain

Poster presentation - Theme 5: NeuroscienceNeuronal migration allows the proper positioning of neurons for establishing functional connectivity of defined neural circuits. We and others reported the restrictive role of Chondroitin sulfate (CS) moieties in axonal fasciculation. CS moieties of proteoglycans are therefore hypothesized to control the timely orchestration of cranial motor neuron migration during hindbrain development by the varying sulfation patterns of the chondroitins between the migrating and ready-to-migrate neurons. Hindbrain explants of E11.5 Sprague Dawley rats were ...postprin

Ginseng: A panacea linking East Asia and North America?

The Supplement title: The Art and Science of Traditional Medicine Part 3: The Global Impact of Traditional Medicinepostprin

Heavy metals in agricultural soils of the Pearl River Delta, South China

Author name used in this publication: S. C. WongAuthor name used in this publication: X. D. LiAuthor name used in this publication: G. ZhangAuthor name used in this publication: S. H. QiAuthor name used in this publication: Y. S. Min2001-2002 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Relationships of trace gases and aerosols and the emission characteristics at Lin'an, a rural site in eastern China, during spring 2001

We present measurements of trace gases and fine aerosols obtained from a rural site in eastern China during 18 February to 30 April 2001. The field program aimed to characterize the variations in aerosol and gaseous pollutant concentrations and the emission signatures from the inland region of eastern China in the spring season. The data included O3, CO, NO, NOy*, SO2, methane, C2-C8 nonmethane hydrocarbons (NMHCs), C 1-C2 halocarbons, and the chemical composition of PM2.5. The average hourly mixing ratios (±standard deviation) of CO, SO2, and NOy* were 677 (±315) ppbv, 15.9 (±14.6) ppbv, and 13.8 (±7.2) ppbv, respectively. The mean daytime ozone mixing ratio was 41 (± 19) ppbv. The most abundant NMHC was ethane (3189 ± 717 pptv), followed by ethyne (2475 ± 1395 pptv), ethene (1679 ± 1455 pptv), and toluene (1529 ± 1608 pptv). Methyl chloride was the most abundant halocarbon (1108 ± 653 pptv). The average concentrations of particulate organic matter (POM, as organic carbon, OC, times 1.4) and elemental carbon (EC) in PM2.5 were 21.5 (±7) μg/m3 and 2.5 (±0.7) μg/m3, respectively, and sulfate and nitrate levels were 17.3 (±6.6) and 6.5 (±4) μg/m3, respectively. CO showed moderate to good correlation with NOy* (r2 = 0.59), OC (r2 = 0.65), CH3Cl (r2 = 0.59), soluble potassium (r2 = 0.53), and many NMHCs, indicating contributions from the burning of biofuel/biomass. CO also correlated with an industrial tracer, C2Cl4, indicative of some influence from industrial sources. SO2, on the other hand, correlated well with EC (r2 = 0.56), reflecting the contribution from the burning of coal. Ammonium was sufficiently abundant to fully neutralize sulfate and nitrate, indicating that there were strong emissions of ammonia from agricultural activities. Silicon and calcium had poor correlations with iron and aluminum, revealing the presence of source(s) for Si and Ca other than from soil. Examination of C2H2/CO, C3H8/C 2H6, nitrate/(nitrate + NOy* , and sulfate/(SO2 + sulfate) suggested that relatively fresh air masses had been sampled at the study site in the spring season. Comparison of the observed ratios/slopes with those derived from emission inventories showed that while the observed SO2/NO y* ratio (1.29 ppbv/ppbv) in March was comparable (within 20%) to the inventory-derived ratio for the study region, the measured CO/NOy* slope (37 ppbv/ppbv) was about 200% larger. The observed slope of CO relative to NMHC (including ethane, propane, butanes, ethene, and ethyne) also indicated the presence of excess CO, compared to the ratios from the inventories. These results strongly suggest that emissions of CO in eastern China have been underrepresented. The findings of this study highlight the importance of characterizing trace gases and aerosols within source regions of the Asian continent. The springtime results were also compared with data previously collected at the site in 1999-2000 and with those obtained on the Transport and Chemical Evolution over the Pacific (TRACE-P) aircraft and from a coastal site in South China for the same study period. Copyright 2004 by the American Geophysical Union

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma

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AtPAP2 modulates the import of the small subunit of Rubisco into chloroplasts

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