A bibliometric study of human–computer interaction research activity in the Nordic-Baltic Eight countries

Human–computer interaction (HCI) has become an important area for designers and developers worldwide, and research activities set in national cultural contexts addressing local challenges are often needed in industry and academia. This study explored HCI research in the Nordic-Baltic countries using bibliometric methods. The results show that the activity varies greatly across the region with activities dominated by Finland, Sweden, and Denmark, even when adjusting for differences in population size and GDP. Research output variations were larger for the top-tier conferences compared to entry-tier conferences and journals. Locally hosted conferences were associated with local increases in research activity. HCI research longevity appears to be an indicator of research maturity and quantity. HCI researchers typically collaborated either with colleagues within the same institution or with researchers from countries outside the Nordic-Baltic region such as US and the UK. There was less collaboration between national and Nordic-Baltic partners. Collaboration appeared especially prevalent for top-tier conference papers. Top-tier conference papers were also more frequently cited than regional-tier and entry-tier conferences, yet journal articles were cited the most. One implication of this study is that the HCI research activity gaps across the Nordic-Baltic countries should be narrowed by increasing the activity in countries with low research outputs. To achieve this, first-time authors could receive guidance through collaborations with experienced authors in the same institution or other labs around the world. More conferences could also be hosted locally. Furthermore, journals may be more effective than conferences if the goal is to accumulate citations.publishedVersio

Probing Molecular Mechanisms of the Hsp90 Chaperone: Biophysical Modeling Identifies Key Regulators of Functional Dynamics

Deciphering functional mechanisms of the Hsp90 chaperone machinery is an important objective in cancer biology aiming to facilitate discovery of targeted anti-cancer therapies. Despite significant advances in understanding structure and function of molecular chaperones, organizing molecular principles that control the relationship between conformational diversity and functional mechanisms of the Hsp90 activity lack a sufficient quantitative characterization. We combined molecular dynamics simulations, principal component analysis, the energy landscape model and structure-functional analysis of Hsp90 regulatory interactions to systematically investigate functional dynamics of the molecular chaperone. This approach has identified a network of conserved regions common to the Hsp90 chaperones that could play a universal role in coordinating functional dynamics, principal collective motions and allosteric signaling of Hsp90. We have found that these functional motifs may be utilized by the molecular chaperone machinery to act collectively as central regulators of Hsp90 dynamics and activity, including the inter-domain communications, control of ATP hydrolysis, and protein client binding. These findings have provided support to a long-standing assertion that allosteric regulation and catalysis may have emerged via common evolutionary routes. The interaction networks regulating functional motions of Hsp90 may be determined by the inherent structural architecture of the molecular chaperone. At the same time, the thermodynamics-based “conformational selection” of functional states is likely to be activated based on the nature of the binding partner. This mechanistic model of Hsp90 dynamics and function is consistent with the notion that allosteric networks orchestrating cooperative protein motions can be formed by evolutionary conserved and sparsely connected residue clusters. Hence, allosteric signaling through a small network of distantly connected residue clusters may be a rather general functional requirement encoded across molecular chaperones. The obtained insights may be useful in guiding discovery of allosteric Hsp90 inhibitors targeting protein interfaces with co-chaperones and protein binding clients

Understanding blog continuance: A model comparison approach

Purpose: The purpose of this paper is to understand blog continuance. Specifically, this paper aims to compare two theoretical models and an integrated model to identify which theoretical models best predicts blog continuance intention. Design/methodology/approach: An empirical study was conducted through an online survey. Data collected from six famous blogs in Taiwan (n = 361) were analyzed using structural equation modeling and pairwise nested F-tests. Findings: Results show that the ECT-IS model and the integrated model have greater explanatory power of blog continuance intention than the technology acceptance model (TAM). The results of pairwise nested F-tests show that the ECT-IS model exhibits statistically significant R 2 improvement compared to TAM. However, the R 2 improvement in the integrated model is not statistically different from that in the ECT-IS model. The ECT-IS model is also more parsimonious than the integrated model. Thus, the ECT-IS is a preferable model. Confirmation and satisfaction are salient factors influencing this intention. Practical implications - The results of this study provide useful information for blogging service providers (BSPs) to enhance and develop useful blog functions for user satisfaction. By revealing the differences and comparisons among these three models, this study can help BSPs promote the benefits of their blogs to strengthen the continuance intentions of their customers. Originality/value: This paper is one of the first studies to examine of influence change of variables and compare the relative ability of two competing theories, ECT-IS and TAM, and an integrated model in explaining blog continuance intention. The results confirm that the ECT-IS is a better model than the other two for explaining blog continuance intention. © Emerald Group Publishing Limited.link_to_subscribed_fulltex

Cognition and emotion in the information systems field : a review of twenty-four years of literature

202208 bcwwNot applicableOthersNational Social Science Foundation of ChinaPublished12 month

Exploring the intellectual cores of the Blockchain–Internet of Things (BIoT)

202208 bcwwAccepted ManuscriptRGCPublishe

The Role of Social Media in Citizen’s Political Participation

Part 5: Social Media and Open ComputingInternational audienceSocial media is becoming important tool for political participation and engagement. Interaction in social media has a strong influence on the propensity to participate in politics. In this research, we argue that IS is in the right position to improve understanding of social media influence in political communication and participation. In this study, the role of social media for political participation is discussed and the result shows that social media plays great role in terms of replacing traditional media, facilitating political engagement, strengthening strategic collaboration as well as the potential to influence governments decisions in relation with politics. We employed qualitative research methodology and concept analysis technique to transcribe interview that can help to identify and arrange the ideas and views of interviewees. Our study explored how citizens engaged in politics through social media. Thus, the media industry, political consultants, politicians, and citizens will need to adjust their behaviors to leverage this new competitive environment abstract should summarize the contents of the paper in short terms, i.e. 150–250 words

Common regulatory control of CTP synthase enzyme activity and filament formation

The ability of enzymes to assemble into visible supramolecular complexes is a widespread phenomenon. Such complexes have been hypothesized to play a number of roles; however, little is known about how the regulation of enzyme activity is coupled to the assembly/disassembly of these cellular structures. CTP synthase is an ideal model system for addressing this question because its activity is regulated via multiple mechanisms and its filament-forming ability is evolutionarily conserved. Our structure–function studies of CTP synthase in Saccharomyces cerevisiae reveal that destabilization of the active tetrameric form of the enzyme increases filament formation, suggesting that the filaments comprise inactive CTP synthase dimers. Furthermore, the sites responsible for feedback inhibition and allosteric activation control filament length, implying that multiple regions of the enzyme can influence filament structure. In contrast, blocking catalysis without disrupting the regulatory sites of the enzyme does not affect filament formation or length. Together our results argue that the regulatory sites that control CTP synthase function, but not enzymatic activity per se, are critical for controlling filament assembly. We predict that the ability of enzymes to form supramolecular structures in general is closely coupled to the mechanisms that regulate their activity