Developmental imaging genetics: challenges and promises for translational research

Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework. Herein, we begin by outlining an experimental strategy by which genetic effects on brain function can be explored using neuroimaging, namely, imaging genetics. We next describe some major findings in imaging genetics to highlight the effectiveness of this strategy for delineating biological pathways and mechanisms by which individual differences in brain function emerge and potentially bias behavior and risk for psychiatric illness. We then discuss the importance of applying imaging genetics to the study of psychopathology within a developmental framework. By beginning to move toward a systems-level approach to understanding pathways to behavioral outcomes as they are expressed across development, it is anticipated that we will move closer to understanding the complexities of the specific mechanisms involved in the etiology of psychiatric disease. Despite the numerous challenges that lie ahead, we believe that developmental imaging genetics has potential to yield highly informative results that will ultimately translate into public health benefits. We attempt to set out guidelines and provide exemplars that may help in designing fruitful translational research applications that incorporate a developmental imaging genetics strategy

Mapping suspended particle and solute concentrations from satellite data

There are no author-identified significant results in this report

Revision of geodetic parameters

Laser data from nine satellites and 12 stations are combined with surface-gravity data to obtain spherical harmonics representing the geopotential complete through degree and order 18. This laser-data-only solution provides a reasonable improvement to the gravity field

Modeling the time-dependent polarization of blazars

Linear polarization is an extremely valuable observational tool for probing the dynamic physical conditions of blazar jets. Some patterns are seen in the data, suggestive of order that can be explained by shock waves and helical magnetic field components. However, much disorder is apparent, which implies that turbulence plays a major role as well, especially in the fluctuations of flux and polarization, and perhaps particle acceleration. Here, we present some actual flux and polarization versus time data, plus simulations of model jets. We analyze the output of the simulations in a manner that can be compared with observational data. The results suggest that the ratio of turbulent to ordered magnetic fields varies with time.AST-1615796 - National Science Foundation; NASA; NNX14AQ58G; NNX15AR45

‘Fishing after News’ and the Ars Apodemica: The Intelligencing Role of the Educational Traveller in the Late Sixteenth Century

This is the final version of the chapter. Available from Brill via the DOI in this record.The subject of this chapter is the sending of news and information from English travellers abroad to the governing circles of late Elizabethan England. A stay abroad carried with it an expectation that casual travellers, to protect and evidence their moral, spiritual and physical health, would make themselves useful, and thus loyal, servants of their domestic government: I will argue that one key method of doing so was by transmitting news and information. Immediately, this invites questions regarding what and who exactly is being discussed. Although I will not fully explore here the complexities of what is meant by ‘news’, ‘knowledge’ and (political) ‘intelligence’, rough distinctions between these terms are implicated in the primary focus of this chapter. These distinctions and the associations they carry bear directly on how we and contemporaries regard the individual who gathers information. This is because the intention and motivation for travel define and justify the traveller: the inflection of their information-gathering activity matters. The crux is that there is an indistinctness surrounding who the traveller is and what they are travelling for; a blurred status or lack of definition that means that the traveller provides a valuable opportunity for access (to news, to people, to places), but also that they are at risk of suspicion and the accusation of immorality, whether they present as the nobleman or gentleman, the ambitious scholar or the employed agent, the youth or the tutor. I would argue that this ambiguity pivots on the kind of information the individual is expected or is seen to gather: in reductive terms, whether it is perceived as defensible learning, infective intelligence or common news.[...

TO MARKET, TO MARKET TO SELL FRESH PRODUCE; BUT WHERE? AND WHEN?

Agribusiness,