Mechanisms and in vivo functions of contact inhibition of locomotion

Contact inhibition of locomotion (CIL) is a process whereby a cell ceases motility or changes its trajectory upon collision with another cell. CIL was initially characterized more than half a century ago and became a widely studied model system to understand how cells migrate and dynamically interact. Although CIL fell from interest for several decades, the scientific community has recently rediscovered this process. We are now beginning to understand the precise steps of this complex behaviour and to elucidate its regulatory components, including receptors, polarity proteins and cytoskeletal elements. Furthermore, this process is no longer just in vitro phenomenology; we now know from several different in vivo models that CIL is essential for embryogenesis and in governing behaviours such as cell dispersion, boundary formation and collective cell migration. In addition, changes in CIL responses have been associated with other physiological processes, such as cancer cell dissemination during metastasis

The Effect of Team Size on the Performance of Continuous Improvement Teams: Is Seven Really the Magic Number?

Part 1: Lean ProductionInternational audienceContinuous improvement teams play an essential role when implementing a corporate improvement programme, the success of which is significantly dependent on the organization of such teams. This paper specifically addresses the effect of team size on the performance of continuous improvement teams. We take insight into a Norwegian case study during the first two years of a lean transformation to explore if there are any indications of an optimum size for continuous improvement teams. The results suggest that there may not be a perfect size for a CI team, rather the performance outcome of different sized teams may depend on the maturity level of the lean programme. Whereas in the establishment phase teams of up to twelve employees seem to perform well, this number appears to reduce when the programme matures. This study may therefore assist practitioners in establishing the right team size dependent on the status of transformation