127 research outputs found
Territorial marketing as a tool for building cooperation of local authorities with investors
The aim of the study was to identify, analyze and evaluate the attitude of entrepreneurs towards
cooperation and relations with the local government authorities. The study attempted to assess the
instruments of territorial marketing in use and their impact on the investment.
The study showed that entrepreneurs have mostly negative assessment of local authorities. Among
marketing tools, only promotion and advertising activities have been noted in use in surveyed
municipalities. Local authorities rest passive when communicating to business – initiative always
belongs to entrepreneurs
The quality level of services provided in local government administration and local business development opportunities
The main objective of the research is to identify, analyse and evaluate the quality of services offered
by local administration and level of satisfaction of local entrepreneurs and other stakeholders in
terms of development prospects for investments. The main problems include: long delays, lack of
competence of the officials, absence of standards for handling various issues. Business sees the
necessity for continuous bilateral efforts being made for improving the relations in order to build
them mutually benefit. Officials expect honesty and assistance in solving problems
The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388
We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-α (TNFα) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia L1210 and P388 receiving 2-CdA combined with TNFα had shorter survival times than animals treated with these agents separately. In contrast, the administration of 2-CdA in conjunction with mutein VI, prolonged the survival of mice inoculated with these leukaemias as compared with animals receiving these agents separately. The results of the present study emphasize the importance of the biological activity of the TNFα molecule N-terminus
A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice
We investigated the influence of recombinant human tumour necrosis
factor alpha (TNF-α) and its derivatives termed muteins III, V,
VI—in which the first 3 to 7 amino acids of native TNF-α have been
replaced—on the survival time of mice inoculated with leukaemia
L1210 or leukaemia P338. TNF-α prolonged the survival of mice with
leukaemia L1210 but did not have any therapeutic activity in
leukaemia P388-bearing mice. Muteins-treated mice with leukaemia
P388 lived longer than animals receiving TNF-α, while those
inoculated with leukaemia L1210 did not show any significant
prolongation of life compared with the TNF-α treated group. The
results presented in this report indicate that the antileukaemic
activity of TNF-α is governed at least in part by the nature of the
N-terminal amino acids
Skuteczność i bezpieczeństwo bortezomibu (Velcade) w leczeniu nawrotowej i opornej postaci szpiczaka plazmocytowego. Doniesienie wstępne
Skuteczność i bezpieczeństwo leczenia białaczki plazmocytowej według programu PAD (bortezomib + doksorubicyna + deksametazon)
Attitudes of Physicians Toward Risk Assessment and Use of Granulocyte-Colony Stimulating Factor (G-Csf) As Primary Prophylaxis (Pp) in Patients (Pts) Receiving Chemotherapy with an Intermediate Risk of Febrile Neutropenia (Fn)
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Specific Inhibition of Estrogen Receptor Alpha Function by Antisense Oligodeoxyribonucleotides
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