1,161 research outputs found
Experimental evidence of differences in the absorption spectra of clustered and isolated ions in erbium doped fibers
The absorption spectra of clustered and isolated ions in erbium-doped germanosilicate fibers have been experimentally studied. The ground state absorption spectra broaden as the degree of erbium-ion clustering increases, indicating that the absorption spectra of clustered ions is significantly different from that of the homogeneous ions. This is confirmed by comparing the broadened absorption spectra with the fibre unbleachable loss spectrum; a direct measurement of the clustered ions. This is the first experimental evidence indicating different absorption cross-sections for the two species of ions in germanosilicate glass, an assumption used in the theoretical description of self-pulsing in erbium doped fiber lasers, but in direct contradiction to the pair-induced quenching model widely used to characterise EDFAs
Diffusion and jump-length distribution in liquid and amorphous CuZr
Using molecular dynamics simulation, we calculate the distribution of atomic
jum ps in CuZr in the liquid and glassy states. In both states
the distribution of jump lengths can be described by a temperature independent
exponential of the length and an effective activation energy plus a
contribution of elastic displacements at short distances. Upon cooling the
contribution of shorter jumps dominates. No indication of an enhanced
probability to jump over a nearest neighbor distance was found. We find a
smooth transition from flow in the liquid to jumps in the g lass. The
correlation factor of the diffusion constant decreases with decreasing
temperature, causing a drop of diffusion below the Arrhenius value, despite an
apparent Arrhenius law for the jump probability
Strong enhancement of spin fluctuations in the low-temperature-tetragonal phase of antiferromagnetically ordered La_{2-x-y}Eu_ySr_xCuO_4
Measurements of the static magnetization, susceptibility and ESR of Gd spin
probes have been performed to study the properties of antiferromagnetically
ordered La_{2-x-y}Eu_ySr_xCuO_4 (x less or equal 0.02) with the low temperature
tetragonal structure. According to the static magnetic measurements the CuO_2
planes are magnetically decoupled in this structural phase. The ESR study
reveals strong magnetic fluctuations at the ESR frequency which are not present
in the orthorhombic phase. It is argued that this drastic enhancement of the
spin fluctuations is due to a considerable weakening of the interlayer exchange
and a pronounced influence of hole motion on the antiferromagnetic properties
of lightly hole doped La_2CuO_4. No evidence for the stripe phase formation at
small hole doping is obtained in the present study.Comment: 10 pages, LaTeX, 3 EPS figures; to be published in Journal of
Physics: Condensed Matte
Orofacial Muscles: Embryonic Development and Regeneration after Injury
Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up in defective muscle regeneration and fibrosis. The aim of this review is to discuss current knowledge on the development and regeneration of orofacial muscles in comparison to trunk and limb muscles. The orofacial muscles include the tongue muscles and the branchiomeric muscles in the lower face. Their main functions are chewing, swallowing, and speech. All orofacial muscles originate from the mesoderm of the pharyngeal arches under the control of cranial neural crest cells. Research in vertebrate models indicates that the molecular regulation of orofacial muscle development is different from that of trunk and limb muscles. In addition, the regenerative ability of orofacial muscles is lower, and they develop more fibrosis than other skeletal muscles. Therefore, specific approaches need to be developed to stimulate orofacial muscle regeneration. Regeneration may be stimulated by growth factors such fibroblast growth factors and hepatocyte growth factor, while fibrosis may be reduced by targeting the transforming growth factor β1 (TGFβ1)/myofibroblast axis. New approaches that combine these 2 aspects will improve the surgical treatment of orofacial muscle defects
4f-spin dynamics in La(2-x-y)Sr(x)Nd(y)CuO(4)
We have performed inelastic magnetic neutron scattering experiments on
La(2-x-y)Sr(x)Nd(y)CuO(4) in order to study the Nd 4f-spin dynamics at low
energies. In all samples we find at high temperatures a quasielastic line
(Lorentzian) with a line width which decreases on lowering the temperature. The
temperature dependence of the quasielastic line width Gamma/2(T) can be
explained with an Orbach-process, i.e. a relaxation via the coupling between
crystal field excitations and phonons. At low temperatures the Nd-4f magnetic
response S(Q,omega) correlates with the electronic properties of the
CuO(2)-layers. In the insulator La(2-y)Nd(y)CuO(4) the quasielastic line
vanishes below 80 K and an inelastic excitation occurs. This directly indicates
the splitting of the Nd3+ ground state Kramers doublet due to the static
antiferromagnetic order of the Cu moments. In La(1.7-x)Sr(x)Nd(0.3)CuO(4) with
x = 0.12, 0.15 and La(1.4-x)Sr(x)Nd(0.6)CuO(4) with x = 0.1, 0.12, 0.15, 0.18
superconductivity is strongly suppressed. In these compounds we observe a
temperature independent broad quasielastic line of Gaussian shape below T about
30 K. This suggests a distribution of various internal fields on different Nd
sites and is interpreted in the frame of the stripe model. In
La(1.8-y)Sr(0.2)Nd(y)CuO(4) (y = 0.3, 0.6) such a quasielastic broadening is
not observed even at lowest temperature.Comment: 8 pages, 10 figures included, to appear in Phys. Rev.
Inhomogeneous Low Frequency Spin Dynamics in La_{1.65}Eu_{0.2}Sr_{0.15}CuO_4
We report Cu and La nuclear magnetic resonance (NMR) measurements in the
title compound that reveal an inhomogeneous glassy behavior of the spin
dynamics. A low temperature peak in the La spin lattice relaxation rate and the
``wipeout'' of Cu intensity both arise from these slow electronic spin
fluctuations that reveal a distribution of activation energies. Inhomogeneous
slowing of spin fluctuations appears to be a general feature of doped lanthanum
cuprate.Comment: 4 pages, 2 figures. Very slight modifications to figure
Identification of target-specific bioisosteric fragments from ligand-protein crystallographic data
Bioisosteres are functional groups or atoms that are structurally different but that can form similar intermolecular interactions. Potential bioisosteres were identified here from analysing the X-ray crystallographic structures for sets of different ligands complexed with a fixed protein. The protein was used to align the ligands with each other, and then pairs of ligands compared to identify substructural features with high volume overlap that occurred in approximately the same region of geometric space. The resulting pairs of substructural features can suggest potential bioisosteric replacements for use in lead-optimisation studies. Experiments with 12 sets of ligand-protein complexes from the Protein Data Bank demonstrate the effectiveness of the procedure
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation
After a brief period of antigenic stimulation, T cells become committed to a program of autonomous expansion and differentiation. We investigated the role of antigen-specific T cell precursor frequency as a possible cell-extrinsic factor impacting T cell programming in a model of allogeneic tissue transplantation. Using an adoptive transfer system to incrementally raise the precursor frequency of antigen-specific CD8+ T cells, we found that donor-reactive T cells primed at low frequency exhibited increased cellular division, decreased development of multifunctional effector activity, and an increased requirement for CD28- and CD154-mediated costimulation relative to those primed at high frequency. The results demonstrated that recipients with low CD4+ and CD8+ donor-reactive T cell frequencies exhibited long-term skin graft survival upon CD28/CD154 blockade, whereas simultaneously raising the frequency of CD4+ T cells to ∼0.5% and CD8+ T cells to ∼5% precipitated graft rejection despite CD28/CD154 blockade. Antigenic rechallenge of equal numbers of cells stimulated at high or low frequency revealed that cells retained an imprint of the frequency at which they were primed. These results demonstrate a critical role for initial precursor frequency in determining the CD8+ T cell requirement for CD28- and CD154-mediated costimulatory signals during graft rejection
Systematic Cu-63 NQR studies of the stripe phase in La(1.6-x)Nd(0.4)Sr(x)CuO(4) for 0.07 <= x <= 0.25
We demonstrate that the integrated intensity of Cu-63 nuclear quadrupole
resonance (NQR) in La(1.6-x)Nd(0.4)Sr(x)CuO(4) decreases dramatically below the
charge-stripe ordering temperature T(charge). Comparison with neutron and X-ray
scattering indicates that the wipeout fraction F(T) (i.e. the missing fraction
of the integrated intensity of the NQR signal) represents the charge-stripe
order parameter. The systematic study reveals bulk charge-stripe order
throughout the superconducting region 0.07 <= x <= 0.25. As a function of the
reduced temperature t = T/T(charge), the temperature dependence of F(t) is
sharpest for the hole concentration x=1/8, indicating that x=1/8 is the optimum
concentration for stripe formation.Comment: 10 pages of text and captions, 11 figures in postscript. Final
version, with new data in Fig.
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