Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia

Patients with glycogen storage disease type Ia (GSD-Ia) develop renal disease of unknown etiology despite intensive dietary therapies. This renal disease shares many clinical and pathological similarities to diabetic nephropathy. We studied the expression of angiotensinogen, angiotensin type 1 receptor, transforming growth factor-β1, and connective tissue growth factor in mice with GSD-Ia and found them to be elevated compared to controls. While increased renal expression of angiotensinogen was evident in 2-week-old mice with GSD-Ia, the renal expression of transforming growth factor-β and connective tissue growth factor did not increase for another week; consistent with upregulation of these factors by angiotensin II. The expression of fibronectin and collagens I, III, and IV was also elevated in the kidneys of mice with GSD-Ia, compared to controls. Renal fibrosis was characterized by a marked increase in the synthesis and deposition of extracellular matrix proteins in the renal cortex and histological abnormalities including tubular basement membrane thickening, tubular atrophy, tubular dilation, and multifocal interstitial fibrosis. Our results suggest that activation of the angiotensin system has an important role in the pathophysiology of renal disease in patients with GSD-Ia

Дж. Х. Миллер как деконструктивист

Анализируется второй деконструктивистский этап литературно-критической деятельности Дж. Х. Миллера на материале 80-90-х годов. Цель данной статьи - показать новый деконструктивистский подход американского критика и выявить специфику его литературно-критического метода.The article deals with the second deconstructive period of J.H. Miller's literary theory and criticism (80-90-s' works). The purpose of the article is to define the new deconstructive approach of the American literary critic and specify his method

Synovial Sarcoma of the Extremities. A Diagnosis that is easily missed

Synovial sarcoma of the extremities is an uncommon type of soft tissue sarcoma occurring predominantly in young adults at the para-articular regions. We present a series of 10 patients with an average age of 44 years and include a follow-up of 39 months. Eight patients had a surgical procedure for a mistaken benign lesion. In contrast to other soft tissue sarcomas, the swellings were associated with pain and most were fixed to the underlying structures. Five patients had a local recurrence after many years, stressing the necessity for close and long term follow-up in these patients

Non-Bacterial Chronic Recurrent Osteomyelitis of the Clavicle

This report details the case of a 12-year-old girl with a painful, progressive swelling of the medial portion of the clavicle with no history of trauma or other constitutional symptoms. All laboratory investigations were normal except for an elevated erythrocyte sedimentation rate (ESR). Initial plain radiographs showed a destructive lesion with magnetic resonance imaging showing features of malignancy. Biopsies revealed osteomyelitis, but with negative bacterial cultures and no evidence of malignancy. Treatment with antibiotics did not result in a favourable response. Over time, the swelling increased in size with episodic exacerbations of pain. Follow-up radiographs showed sclerosis and hyperostosis. After five years, this was recognized as non-bacterial chronic recurrent osteomyelitis of the clavicle

Periodic corrugation on dynamic fracture surface in brittle bulk metallic glass

Dynamic crack propagation in a model brittle bulk metallic glass (BMG) is studied. Contrary to other brittle glassy materials, the authors find nanometer scale out-of-plane periodic corrugations along the crack surface of the BMG. The nanoscale periodicity remains nearly constant at different loading rates. An interpretation is presented to explain the evolution and the periodic coalescence of the nanometer scale cavities along the crack surface. The observation sheds light on the origin of dynamic fracture surface roughening in brittle materials and could be generally applicable to brittle materials

Direct measurement of optical quasidistribution functions: multimode theory and homodyne tests of Bell's inequalities

We develop a multimode theory of direct homodyne measurements of quantum optical quasidistribution functions. We demonstrate that unbalanced homodyning with appropriately shaped auxiliary coherent fields allows one to sample point-by-point different phase space representations of the electromagnetic field. Our analysis includes practical factors that are likely to affect the outcome of a realistic experiment, such as non-unit detection efficiency, imperfect mode matching, and dark counts. We apply the developed theory to discuss feasibility of observing a loophole-free violation of Bell's inequalities by measuring joint two-mode quasidistribution functions under locality conditions by photon counting. We determine the range of parameters of the experimental setup that enable violation of Bell's inequalities for two states exhibiting entanglement in the Fock basis: a one-photon Fock state divided by a 50:50 beam splitter, and a two-mode squeezed vacuum state produced in the process of non-degenerate parametric down-conversion.Comment: 18 pages, 7 figure

Connecting Numerical Relativity and Data Analysis of Gravitational Wave Detectors

Gravitational waves deliver information in exquisite detail about astrophysical phenomena, among them the collision of two black holes, a system completely invisible to the eyes of electromagnetic telescopes. Models that predict gravitational wave signals from likely sources are crucial for the success of this endeavor. Modeling binary black hole sources of gravitational radiation requires solving the Eintein equations of General Relativity using powerful computer hardware and sophisticated numerical algorithms. This proceeding presents where we are in understanding ground-based gravitational waves resulting from the merger of black holes and the implications of these sources for the advent of gravitational-wave astronomy.Comment: Appeared in the Proceedings of 2014 Sant Cugat Forum on Astrophysics. Astrophysics and Space Science Proceedings, ed. C.Sopuerta (Berlin: Springer-Verlag

Entanglement, Bell Inequalities and Decoherence in Particle Physics

We demonstrate the relevance of entanglement, Bell inequalities and decoherence in particle physics. In particular, we study in detail the features of the ``strange'' $K^0 \bar K^0$ system as an example of entangled meson--antimeson systems. The analogies and differences to entangled spin--1/2 or photon systems are worked, the effects of a unitary time evolution of the meson system is demonstrated explicitly. After an introduction we present several types of Bell inequalities and show a remarkable connection to CP violation. We investigate the stability of entangled quantum systems pursuing the question how possible decoherence might arise due to the interaction of the system with its ``environment''. The decoherence is strikingly connected to the entanglement loss of common entanglement measures. Finally, some outlook of the field is presented.Comment: Lectures given at Quantum Coherence in Matter: from Quarks to Solids, 42. Internationale Universit\"atswochen f\"ur Theoretische Physik, Schladming, Austria, Feb. 28 -- March 6, 2004, submitted to Lecture Notes in Physics, Springer Verlag, 45 page

Qualidade de Vida e Atitudes dos Idosos Face à Velhice

A problemática do envelhecimento tem assumido, nos últimos anos, uma crescente importância na consciência coletiva da população, tornando-se cada vez mais importante compreender a população idosa e a sua realidade. Posto isto, foi realizado um estudo quantitativo e correlacional, que teve como objectivo avaliar a qualidade de vida e atitudes face à velhice de idosos, bem como a relação entre estas e as variáveis sociodemográficas e familiares. Foram inquiridos 100 idosos, com mais de 65 anos e sem deficit cognitivo . Para a recolha de dados utilizou-se uma entrevista estruturada, constituída dados sóciodemográficos do idoso, WHOQOL-AGE (Caballero, Miret, Power, Chatterji, Tobiasz-Adamczyk, Koskinen, Leonardi, Olaya, Haro &Ayuso-Mateos, 2013) e o AAQ ( Laidlaw, Power, Schmidt and the WHOQOL-OLD Group, 2007). Dos resultados destacamos os seguintes: A amostra é constituída por 52% de idosos do sexo masculino tendo uma média de idades de 74,7 (DP=6,8). È no fator Perdas Psicossociais e no Desenvolvimento Psicológico que os idosos têm uma melhor atitude face ao envelhecimento. É no item “Tem dinheiro suficiente para satisfazer as suas necessidades?” que os idosos apresentam uma menor qualidade de vida. Não ter doença diagnosticada e ser do sexo masculino permitem ter melhores atitudes face ao envelhecimento. A Qualidade de Vida está relacionada com a idade, com o estado de saúde e com a intensidade de preocupação da família. Constatou-se que os idosos que não estão institucionalizados apresentam uma melhor qualidade de vida e uma melhor atitude face à velhice. Quem não precisa de ajudas técnicas para se movimentar apresenta uma melhor qualidade de vida. Diferenças nas atitudes face ao envelhecimento consoante a residência onde habita são significativas nas mudanças físicas e no desenvolvimento psicológico sendo que os idosos que não vivem em lares têm uma atitude mais positiva em ambos os fatores. / Over the past few years the issue of aging has played a growing importance in the population`s collective consciousness becoming increasingly important to understand the elderly population and this reality. Therefore a quantitative correlational study was performed to assess the quality of life of seniors and their attitudes towards old age, and the relationship between these and the socio-demographic and family factors. 100 seniors with more than 65 years and without cognitive deficit were surveyed. For data collection we used a structured interview consisting of sociodemographic data of the elderly, WHOQOL-AGE (Caballero Miret Power Chatterji Tobiasz-Adamczyk Koskinen Leonardi Olaya Ayuso-Mateos & Haro 2013) and AAQ (Laidlaw Power Schmidt and the WHOQOL-OLD Group 2007). We highlight: The sample is composed of 52% of males with a mean age of 74.7 (SD = 6.8). It is in the factor Psychosocial Losses and Psychological Development that elderly people have a better attitude towards aging. It is in the item "Do you have enough money to meet your needs?" that seniors show less quality of life. Not having illness and being male allows having better attitudes towards aging. Quality of Life is related to age, health condition and the intensity of family concerns. It was observed that the elderly who are not institutionalized have a better quality of life and a better attitude towards old age. Who does not need assistive devices to move around has a better quality of life. Differences in attitudes towards aging, according to residency, are significant in physical changes and psychological development, thus verifying that elderly who do not live in nursing homes have a more positive attitude in both factors

Dynamics of multipartite quantum correlations under decoherence

Quantum discord is an optimal resource for the quantification of classical and non-classical correlations as compared to other related measures. Geometric measure of quantum discord is another measure of quantum correlations. Recently, the geometric quantum discord for multipartite states has been introduced by Jianwei Xu [arxiv:quant/ph.1205.0330]. Motivated from the recent study [Ann. Phys. 327 (2012) 851] for the bipartite systems, I have investigated global quantum discord (QD) and geometric quantum discord (GQD) under the influence of external environments for different multipartite states. Werner-GHZ type three-qubit and six-qubit states are considered in inertial and non-inertial settings. The dynamics of QD and GQD is investigated under amplitude damping, phase damping, depolarizing and flipping channels. It is seen that the quantum discord vanishes for p>0.75 in case of three-qubit GHZ states and for p>0.5 for six qubit GHZ states. This implies that multipartite states are more fragile to decoherence for higher values of N. Surprisingly, a rapid sudden death of discord occurs in case of phase flip channel. However, for bit flip channel, no sudden death happens for the six-qubit states. On the other hand, depolarizing channel heavily influences the QD and GQD as compared to the amplitude damping channel. It means that the depolarizing channel has the most destructive influence on the discords for multipartite states. From the perspective of accelerated observers, it is seen that effect of environment on QD and GQD is much stronger than that of the acceleration of non-inertial frames. The degradation of QD and GQD happens due to Unruh effect. Furthermore, QD exhibits more robustness than GQD when the multipartite systems are exposed to environment.Comment: 15 pages, 4 figures, 4 table