Acceleration and Classical Electromagnetic Radiation

Classical radiation from an accelerated charge is reviewed along with the reciprocal topic of accelerated observers detecting radiation from a static charge. This review commemerates Bahram Mashhoon's 60th birthday.Comment: To appear in Gen. Rel. Gra

The flip flop nozzle extended to supersonic flows

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76293/1/AIAA-1992-2724-750.pd

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.

Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS

Cold War : a Transnational Approach to a Global Heritage

Although within living memory, many countries now consider their surviving Cold War architecture as part of their heritage. It can even be a priority for heritage managers given that significant buildings are often suitable for reuse while extensive ‘brownfield’ sites such as airfields can be used for large-scale redevelopment. In a number of countries whose work we refer to here (notably the United Kingdom and elsewhere in Europe), agencies responsible for managing their country’s heritage have approached this priority by creating national inventories of sites and buildings with a view to taking informed decisions on their future. This paper presents the argument that the wider international context of the Cold War provides a more appropriate (or additional, higher-level) framework for such decision making. Such a ‘transnational’ approach would allow the comparison of similar (e.g. European) sites not merely within national borders but across the full extent of their western NATO1 deployment in Europe and North America. Taking this approach would also allow comparison with related sites in countries that formed part of the eastern-bloc Warsaw Pact.2 After outlining some examples of how national agencies have approached their Cold War heritage, this paper presents the four stages of this transnational approach making provision for an improved understanding and management of Cold War heritage sites wherever they occur. With a specific focus on the direct comparison between England and Russia, and also referring to sites surviving elsewhere within the former NATO and Warsaw Pact regions, as well as the United States, we argue that this four-stage approach: provides new understandings of a complex archaeological and architectural record; gives fresh perspectives on significance; and (importantly in a time of geopolitical instability) does so in a spirit of cooperation and friendship

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID