Backward pion-nucleon scattering

A global analysis of the world data on differential cross sections and polarization asymmetries of backward pion-nucleon scattering for invariant collision energies above 3 GeV is performed in a Regge model. Including the $N_\alpha$, $N_\gamma$, $\Delta_\delta$ and $\Delta_\beta$ trajectories, we reproduce both angular distributions and polarization data for small values of the Mandelstam variable $u$, in contrast to previous analyses. The model amplitude is used to obtain evidence for baryon resonances with mass below 3 GeV. Our analysis suggests a $G_{39}$ resonance with a mass of 2.83 GeV as member of the $\Delta_{\beta}$ trajectory from the corresponding Chew-Frautschi plot.Comment: 12 pages, 16 figure

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting

The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure

Adverse posttraumatic neuropsychiatric sequelae (APNS) are common among civilian trauma survivors and military veterans. These APNS, as traditionally classified, include posttraumatic stress, postconcussion syndrome, depression, and regional or widespread pain. Traditional classifications have come to hamper scientific progress because they artificially fragment APNS into siloed, syndromic diagnoses unmoored to discrete components of brain functioning and studied in isolation. These limitations in classification and ontology slow the discovery of pathophysiologic mechanisms, biobehavioral markers, risk prediction tools, and preventive/treatment interventions. Progress in overcoming these limitations has been challenging because such progress would require studies that both evaluate a broad spectrum of posttraumatic sequelae (to overcome fragmentation) and also perform in-depth biobehavioral evaluation (to index sequelae to domains of brain function). This article summarizes the methods of the Advancing Understanding of RecOvery afteR traumA (AURORA) Study. AURORA conducts a large-scale (n = 5000 target sample) in-depth assessment of APNS development using a state-of-the-art battery of self-report, neurocognitive, physiologic, digital phenotyping, psychophysical, neuroimaging, and genomic assessments, beginning in the early aftermath of trauma and continuing for 1 year. The goals of AURORA are to achieve improved phenotypes, prediction tools, and understanding of molecular mechanisms to inform the future development and testing of preventive and treatment interventions

Quantum turbulence in 4He, oscillating grids, and where do we go next?

Experimental approaches to the study of quantum turbulence (QT) in superfluid 4He in the low temperature limit, where the normal fluid density is effectively zero, are considered. A succinct general introduction covers liquid 4He, superfluidity, critical velocities for the onset of dissipation, quantized vortex lines and QT. The QT can be created mechanically by the oscillation of wires or grids above characteristic critical velocities. The interesting dynamics of the oscillating grid are discussed. It exhibits an enhanced effective mass due to backflow, as expected from classical hydrodynamics. It is found that the critical velocity attributable to the onset of QT production rises with increasing temperature. Oscillating objects like grids or wires create QT that is not well-characterized in terms of length scale, and the QT is not spatially homogeneous. The QT can be detected by the trapping of negative ions on vortex cores. Although the corresponding capture cross-section has not yet been measured, it is evidently very small, so that the technique cannot be expected to be a very sensitive one. In the future it is hoped to create well-characterized, homogeneous QT by means of a drawn grid. Improved sensitivity in the detection of QT is being sought through calorimetric techniques that monitor the temperature rise of the liquid caused by the decay of the vortex lines

Creation of quantized vortices at the lambda transition in liquid Helium-4

A fast (ca. 3 ms) adiabatic expansion of a volume of liquid He-4 through the lambda transition is being used to study the nature of the transition and to model the cosmological false vacuum to true vacuum phase transition of the early universe. Preliminary results are reported showing that, in accordance with theoretical predictions by W H Zurek (Nature 317, 505; 1985), there is copious production of quantized vortex lines, which represent the superfluid analogue of cosmic strings. The line density after the expansion appears to decay in two distinct stages, with a fast decay being followed by a much slower one, in agreement with earlier work on the decay of quantum turbulence created in thermal counterflow. Extrapolation of the initial fast decay suggests an initial line density, immediately following the expansion, of ca. 10 to power 7 per square cm. Smaller, but still substantial, vortex densities are also found to occur when the system is expanded from below the lambda transition, and the physical implications are discussed