Solar electric propulsion for Mars transport vehicles

Solar electric propulsion (SEP) is an alternative to chemical and nuclear powered propulsion systems for both piloted and unpiloted Mars transport vehicles. Photovoltaic solar cell and array technologies were evaluated as components of SEP power systems. Of the systems considered, the SEP power system composed of multijunction solar cells in an ENTECH domed fresnel concentrator array had the least array mass and area. Trip times to Mars optimized for minimum propellant mass were calculated. Additionally, a preliminary vehicle concept was designed

On Languages Accepted by P/T Systems Composed of joins

Recently, some studies linked the computational power of abstract computing systems based on multiset rewriting to models of Petri nets and the computation power of these nets to their topology. In turn, the computational power of these abstract computing devices can be understood by just looking at their topology, that is, information flow. Here we continue this line of research introducing J languages and proving that they can be accepted by place/transition systems whose underlying net is composed only of joins. Moreover, we investigate how J languages relate to other families of formal languages. In particular, we show that every J language can be accepted by a log n space-bounded non-deterministic Turing machine with a one-way read-only input. We also show that every J language has a semilinear Parikh map and that J languages and context-free languages (CFLs) are incomparable

Implementation of fatigue model for unidirectional laminate based on finite element analysis : theory and practice

The aim of this study is to deal with the simulation of intra-laminar fatigue damage in unidirectional composite under multi-axial and variable amplitude loadings. The variable amplitude and multi-axial loading is accounted for by using the damage hysteresis operator based on Brokate method [6]. The proposed damage model for fatigue is based on stiffness degradation laws from Van Paepegem combined with the 'damage' cycle jump approach extended to deal with unidirectional carbon fibres. The parameter identification method is here presented and parameter sensitivities are discussed. The initial static damage of the material is accounted for by using the LadevSze damage model and the permanent shear strain accumulation based on Van Paepegem's formulation. This approach is implemented into commercial software (Siemens PLM). The validation case is run on a bending test coupon (with arbitrary stacking sequence and load level) in order to minimise the risk of inter-laminar damages. This intra-laminar fatigue damage model combined efficient methods with a low number of tests to identify the parameters of the stiffness degradation law, this overall procedure for fatigue life prediction is demonstrated to be cost efficient at industrial level. This work concludes on the next challenges to be addressed (validation tests, multiple-loadings validation, failure criteria, inter-laminar damages...)

A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2.

In a pilot study six patients received 4 days' treatment with interleukin 2 (IL-2) [cumulative dose (CD) 264 +/- 26 x 10(6) IU m-2] and C1 esterase inhibitor (C1-INH) (loading dose 2,000 U, followed by 500-1,000 U twice daily). Toxicity was compared with that in patients given 4 days' treatment with standard (CD 66 +/- 12 x 10(6) IU m-2) or escalating-dose (CD 99 +/- 8 x 10(6) IU m-2) IL-2. IL-2-induced hypotension was equivalent and complement activation was less after IL-2 + C1-INH (C3a = 10.5 +/- 3.2 nmol l-1) than following standard (14.1 +/- 8.4 nmol l-1) or escalating-dose (18.3 +/- 2.9 nmol l-1) IL-2. This study demonstrates that C1-INH administration during IL-2 treatment is safe and warrants further study to evaluate its ability to ameliorate IL-2-induced toxicity

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

Background: Atopic dermatitis (AD) affects children of all skin types. Most research has focused on light skin types. Studies investigating biomarkers in people with AD with dark skin types are lacking. Objectives: To explore skin barrier and immune response biomarkers in stratum corneum (SC) tape strips from children with AD with different skin types. Methods: Tape strips were collected from lesional and nonlesional forearm skin of 53 children with AD and 50 controls. We analysed 28 immunomodulatory mediators, and natural moisturizing factors (NMF) and corneocyte morphology. Results: Interleukin (IL)-1β, IL-18, C-X-C motif chemokine (CXCL) 8 (CXCL8), C-C motif chemokine ligand (CCL) 22 (CCL22), CCL17, CXCL10 and CCL2 were significantly higher (P < 0·05) in lesional AD skin compared with nonlesional AD skin; the opposite trend was seen for IL-1α. CXCL8, CCL2 and CCL17 showed an association with objective SCORing Atopic Dermatitis score. NMF levels showed a gradual decrease from healthy skin to nonlesional and lesional AD skin. This gradual decreasing pattern was observed in skin type II but not in skin type VI. Skin type VI showed higher NMF levels in both nonlesional and lesional AD skin than skin type II. Corneocyte morphology was significantly different in lesional AD skin compared with nonlesional AD and healthy skin. Conclusions: Minimally invasive tape-stripping is suitable for the determination of many inflammatory mediators and skin barrier biomarkers in children with AD. This study shows differences between children with AD with skin type II and skin type VI in NMF levels, suggesting that some aspects of pathophysiological mechanisms may differ in AD children with light versus dark skin types

Feedback control of arm movements using Neuro-Muscular Electrical Stimulation (NMES) combined with a lockable, passive exoskeleton for gravity compensation.

Within the European project MUNDUS, an assistive framework was developed for the support of arm and hand functions during daily life activities in severely impaired people. This contribution aims at designing a feedback control system for Neuro-Muscular Electrical Stimulation (NMES) to enable reaching functions in people with no residual voluntary control of the arm and shoulder due to high level spinal cord injury. NMES is applied to the deltoids and the biceps muscles and integrated with a three degrees of freedom (DoFs) passive exoskeleton, which partially compensates gravitational forces and allows to lock each DOE The user is able to choose the target hand position and to trigger actions using an eyetracker system. The target position is selected by using the eyetracker and determined by a marker-based tracking system using Microsoft Kinect. A central controller, i.e., a finite state machine, issues a sequence of basic movement commands to the real-time arm controller. The NMES control algorithm sequentially controls each joint angle while locking the other DoFs. Daily activities, such as drinking, brushing hair, pushing an alarm button, etc., can be supported by the system. The robust and easily tunable control approach was evaluated with five healthy subjects during a drinking task. Subjects were asked to remain passive and to allow NMES to induce the movements. In all of them, the controller was able to perform the task, and a mean hand positioning error of less than five centimeters was achieved. The average total time duration for moving the hand from a rest position to a drinking cup, for moving the cup to the mouth and back, and for finally returning the arm to the rest position was 71 s

The Mira Distance to M101 and a 4% Measurement of H0

The giant spiral galaxy M101 is host to the nearest recent Type Ia Supernova (SN 2011fe) and thus has been extensively monitored in the near-infrared to study the late-time lightcurve of the supernova. Leveraging this existing baseline of observations, we derive the first Mira-based distance to M101 by discovering and classifying a sample of 211 Miras with periods ranging from 240 to 400 days in the supernova field. Combined with new HST WFC3/IR channel observations, our dataset totals 11 epochs of F110W (HST $YJ$) and 13 epochs of F160W (HST $H$) data spanning $\sim$2900 days. We adopt absolute calibrations of the Mira Period-Luminosity Relation based on geometric distances to the Large Magellanic Cloud and the water megamaser host galaxy NGC 4258, and find $\mu_{\rm M101} =$ 29.10 $\pm$ 0.06 mag. This distance is in 1$\sigma$ agreement with most other recent Cepheid and Tip of the Red Giant Branch distance measurements to M101. Including the previous Mira-SNIa host, NGC 1559 and SN 2005df, we determine the fiducial SN Ia peak luminosity, $M^0_B = -19.27 \pm 0.09$ mag. With the Hubble diagram of SNe Ia, we derive $H_0 = 72.37 \pm 2.97$ km s$^{-1}$Mpc$^{-1}$, a $4.1\%$ measurement of $H_0$ using Miras. We find excellent agreement with recent Cepheid distance ladder measurements of $H_0$ and confirm previous indications that the local universe value of $H_0$ is higher than the early-universe value at $\sim$ $95\%$ confidence. Currently, the Mira-based $H_0$ measurement is still dominated by the statistical uncertainty in the SN Ia peak magnitude.Comment: 22 pages, 11 figures, accepted to Ap