303 research outputs found
Ising magnets with mobile defects
Motivated by recent experiments on cuprates with low-dimensional magnetic
interactions, a new class of two-dimensional Ising models with short-range
interactions and mobile defects is introduced and studied. The non-magnetic
defects form lines, which, as temperature increases, first meander and then
become unstable. Using Monte Carlo simulations and analytical low- and
high-temperature considerations, the instability of the defect stripes is
monitored for various microscopic and thermodynamic quantities in detail for a
minimal model, assuming some of the couplings to be indefinitely strong. The
robustness of the findings against weakening the interactions is discussed as
well
Highly Dispersive Spin Excitations in the Chain Cuprate Li2CuO2
We present an inelastic neutron scattering investigation of Li2CuO2 detecting
the long sought quasi-1D magnetic excitations with a large dispersion along the
CuO2-chains studied up to 25 meV. The total dispersion is governed by a
surprisingly large ferromagnetic (FM) nearest-neighbor exchange integral
J1=-228 K. An anomalous quartic dispersion near the zone center and a
pronounced minimum near (0,0.11,0.5) r.l.u. (corresponding to a spiral
excitation with a pitch angle about 41 degree point to the vicinity of a 3D
FM-spiral critical point. The leading exchange couplings are obtained applying
standard linear spin-wave theory. The 2nd neighbor inter-chain interaction
suppresses a spiral state and drives the FM in-chain ordering below the Ne'el
temperature. The obtained exchange parameters are in agreement with the results
for a realistic five-band extended Hubbard Cu 3d O 2p model and L(S)DA+U
predictions.Comment: 6 pages, 4 figures, submitted to Europhys. Let
Magnetodielectric and magnetoelastic coupling in TbFe3(BO3)4
We have studied the magnetodielectric and magnetoelastic coupling in
TbFe3(BO3)4 single crystals by means of capacitance, magnetostriction and Raman
spectroscopy measurements. The data reveal strong magnetic field effects on the
dielectric constant and on the macroscopic sample length which are associated
to long range magnetic ordering and a field-driven metamagnetic transition. We
discuss the coupling of the dielectric, structural, and magnetic order
parameters and attribute the origin of the magnetodielectric coupling to phonon
mode shifts according to the Lyddane-Sachs-Teller (LST) relation.Comment: Accepted for publication in Physical Review
Thermodynamic and structural aspects of the potential energy surface of simulated water
Relations between the thermodynamics and dynamics of supercooled liquids
approaching a glass transition have been proposed over many years. The
potential energy surface of model liquids has been increasingly studied since
it provides a connection between the configurational component of the partition
function on one hand, and the system dynamics on the other. This connection is
most obvious at low temperatures, where the motion of the system can be
partitioned into vibrations within a basin of attraction and infrequent
inter-basin transitions. In this work, we present a description of the
potential energy surface properties of supercooled liquid water. The dynamics
of this model has been studied in great details in the last years.
Specifically, we locate the minima sampled by the liquid by ``quenches'' from
equilibrium configurations generated via molecular dynamics simulations. We
calculate the temperature and density dependence of the basin energy,
degeneracy, and shape. The temperature dependence of the energy of the minima
is qualitatively similar to simple liquids, but has anomalous density
dependence. The unusual density dependence is also reflected in the
configurational entropy, the thermodynamic measure of degeneracy. Finally, we
study the structure of simulated water at the minima, which provides insight on
the progressive tetrahedral ordering of the liquid on cooling
Liquid Limits: The Glass Transition and Liquid-Gas Spinodal Boundaries of Metastable Liquids
The liquid-gas spinodal and the glass transition define ultimate boundaries
beyond which substances cannot exist as (stable or metastable) liquids. The
relation between these limits is analyzed {\it via} computer simulations of a
model liquid. The results obtained indicate that the liquid - gas spinodal and
the glass transition lines intersect at a finite temperature, implying a glass
- gas mechanical instability locus at low temperatures. The glass transition
lines obtained by thermodynamic and dynamic criteria agree very well with each
other.Comment: 5 pages, 4 figures, to appear in Phys. Rev. Let
Lifetime of quasi-particles in the nearly-free electron metal Sodium
We report a high-resolution angle-resolved photoemission (ARPES) study of the
prototypical nearly-free-electron metal sodium. The observed mass enhancement
is slightly smaller than that derived in previous studies. The new results on
the lifetime broadening increase the demand for theories beyond the random
phase approximation. Our results do not support the proposed strong enhancement
of the scattering rates of the charge carriers due to a coupling to spin
fluctuations. Moreover, a comparison with earlier electron energy-loss data on
sodium yields a strong reduction of the mass enhancement of dipolar
electron-hole excitations compared to that of monopole hole excitations,
measured by ARPES.Comment: 5 pages, 6 figure
Two energy gaps and Fermi surface 'arcs' in NbSe2
Using angle-resolved photoemission spectroscopy (ARPES), we report on the
direct observation of the energy gap in 2H-NbSe2 caused by the charge-density
waves (CDW). The gap opens in the regions of the momentum space connected by
the CDW vectors, which implies a nesting mechanism of CDW formation. In
remarkable analogy with the pseudogap in cuprates, the detected energy gap also
exists in the normal state (T>T0) where it breaks the Fermi surface into
'arcs', it is non-monotonic as a function of temperature with a local minimum
at the CDW transition temperature (T0) and it forestalls the superconducting
gap by excluding the nested portions of the Fermi surface from participating in
superconductivity.Comment: Related work
http://www.ifw-dresden.de/institutes/iff/research/SC/arpe
The relationship between fragility, configurational entropy and the potential energy landscape of glass forming liquids
Glass is a microscopically disordered, solid form of matter that results when
a fluid is cooled or compressed in such a fashion that it does not crystallise.
Almost all types of materials are capable of glass formation -- polymers, metal
alloys, and molten salts, to name a few. Given such diversity, organising
principles which systematise data concerning glass formation are invaluable.
One such principle is the classification of glass formers according to their
fragility\cite{fragility}. Fragility measures the rapidity with which a
liquid's properties such as viscosity change as the glassy state is approached.
Although the relationship between features of the energy landscape of a glass
former, its configurational entropy and fragility have been analysed previously
(e. g.,\cite{speedyfr}), an understanding of the origins of fragility in these
features is far from being well established. Results for a model liquid, whose
fragility depends on its bulk density, are presented in this letter. Analysis
of the relationship between fragility and quantitative measures of the energy
landscape (the complicated dependence of energy on configuration) reveal that
the fragility depends on changes in the vibrational properties of individual
energy basins, in addition to the total number of such basins present, and
their spread in energy. A thermodynamic expression for fragility is derived,
which is in quantitative agreement with {\it kinetic} fragilities obtained from
the liquid's diffusivity.Comment: 8 pages, 3 figure
TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.
A diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli. We hypothesized that abnormal function of innate immune pattern recognition could explain the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients with rosacea expressed higher amounts of Toll-like receptor 2 (TLR2) than normal patients. Increased expression of TLR2 was not seen in other inflammatory skin disorders such as atopic dermatitis or psoriasis. Overexpression of TLR2 on keratinocytes, treatment with TLR2 ligands, and analysis of TLR2-deficient mice resulted in a calcium-dependent release of kallikrein 5 from keratinocytes, a critical protease involved in the pathogenesis of rosacea. These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea
Practical guidelines for monitoring and management of coagulopathy following tisagenlecleucel CAR T-cell therapy
Cytokine release syndrome (CRS) is a systemic inflammatory response associated with chimeric antigen receptor T-cell (CAR-T) therapies. In severe cases, CRS can be associated with coagulopathy and hypofibrinogenemia. We present our global multicenter experience with CRS-associated coagulopathy after tisagenlecleucel therapy in 137 patients with relapsed or refractory B-cell acute lymphoblastic leukemia from the ELIANA and ENSIGN trials. These trials included clinical guidelines for fibrinogen replacement during CRS-associated coagulopathy. Hypofibrinogenemia requiring replacement was observed only in patients with severe CRS. A higher percentage of patients who required replacement were <10 years old, compared with those who did not require replacement. Twenty-three patients received replacement for hypofibrinogenemia (<1.5 g/L); 9 of them developed marked hypofibrinogenemia (<1 g/L). Very low fibrinogen levels (<1 g/L) were documented in patients before maximal CRS (n = 1), during maximal CRS (n = 7), and at CRS improvement (n = 1). Although hypofibrinogenemia was the most clinically significant coagulopathy, some patients also developed prolonged prothrombin time and activated partial thromboplastin time and increased international normalized ratio, further increasing the risk of bleeding. Hypofibrinogenemia was effectively managed using fibrinogen concentrate or cryoprecipitate replacement; severe (grade 4) bleeding events were rare (n = 2). CRS-associated coagulopathy with hypofibrinogenemia is manageable according to empiric guidelines of fibrinogen replacement for CAR-T trials. Fibrinogen concentrate should be used when cryoprecipitate is not reliably available. Monitoring fibrinogen levels in patients with moderate or severe CRS is essential for avoiding potentially fatal bleeding events
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