Conocimientos, actitudes y prácticas en VIH/SIDA en adolescentes de 14 a 19 años que acuden al Hospital Roatán Islas de la Bahía. Honduras. Marzo del 2005.

Estudio descriptivo de corte transversal. Se encontró que el perfil sociodemográfico representativo de los adolescentes de ambos sexos estudiados es de 18 a 19 años de edad de raza mestiza, con secundaria incompleta, evangélicos, que no trabajan, solteros del género femenino, que tienen vida sexual activa y que realizan diferentes prácticas sexuales sin protección. Estos tienen conocimientos sobre prevención y modo de transmisión del VIH/SIDA, y las actitudes en cuanto a realizar relaciones sexuales fueron indiferentes, ya que no estaban dispuestos a cambiar su comportamiento, sabiendo que enfrentan una pandemia mundial que atenta contra la vida y los lleva a la muerte. Las estadísticas a nivel nacional en Honduras realizadas por UNICEF, en jóvenes adolescentes de 15 a 23 años, en el año 2002 reporta, que estos ya han iniciado vida sexual activa en un 56% y un 23% haber padecido de secreciones anormales por los genitales lo que se considera que es uno de los riesgos asociados al VIH/SIDA. Donde la sexualidad produce en muchos jóvenes ansiedad y turbación; y esto les impide que los jóvenes utilicen condón, lo cual se requiere del conocimiento y cooperación de la pareja; es por eso que estos suelen de carecer de actitudes para hacerlo. Se recomiendan campañas masivas de educación basadas esencialmente en una estrategia de Abstinencia, Fidelidad, y Preservativo llamadas estrategias ABC en inglés

Additional file 1: of Serum periostin does not reflect type 2-driven inflammation in COPD

Supplementary Tables. (DOCX 95 kb

Recurrently mutated genes in tumors from patients who progressed under afatinib.

<p>Recurrently mutated genes in tumors from patients who progressed under afatinib.</p

Overview of significantly involved pathways in patients’ progressive disease on afatinib and the involved mutated genes.

<p>Overview of significantly involved pathways in patients’ progressive disease on afatinib and the involved mutated genes.</p

EGFR mutation status in tumor biopsies of a cohort of 38 advanced NSCLC patients.

<p>EGFR mutation status in tumor biopsies of a cohort of 38 advanced NSCLC patients.</p

Patient characteristics of the afatinib treated group according to T790M mutation.

<p>Patient characteristics of the afatinib treated group according to T790M mutation.</p

Median PFS for sequential treatments in T790M positive and negative NSCLC patients.

<p>After first generation EGFR-TKI, 22 patients had a T790M and 7 did not. All patients received afatinib, afterwards.</p

Median PFS in OS axis for sequential treatments in T790M positive and negative advanced NSCLC patients.

<p>Survival outcome of afatinib treatment is shown after first generation EGFR-TKI treatment. The X-axis represents the overall survival. The bars indicate the progression free survival for afatinib.</p

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide1. We performed a genetic association in 15,256 cases and 47,936 controls, with replication of select top results (P < 5x10-6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples2-7; however, 4 (EEFSEC, DSP, MTCL1, and SFTPD) are novel. We noted 2 loci shared with pulmonary fibrosis8,9 (FAM13A and DSP) but with opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma; however, one locus has been implicated in the joint susceptibility to asthma and obesity10. We also identified genetic correlation between COPD and asthma. Our findings highlight novel loci, demonstrate the importance of specific lung function loci to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases