Prenatal exposures and exposomics of asthma

This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi

Ideotype definition to adapt legumes to climate change : A case study for field pea in Northern Italy

One of the key strategies to alleviate negative impacts of climate change on crop production is the development of new cultivars better adapted to the conditions expected in the future. Despite the role of legumes as protein sources, medium- and long-term strategies currently debated mainly focus on agricultural policies and on improved management practices, whereas ideotyping studies using climate projections are scarcely reported. The objective of this study was to define pea ideotypes improved for yield and irrigation water productivity targeting current climate and four future projections centred on 2040, resulting from the combination of two General Circulation Models (HadGEM2 and GISS-ES) and two Representative Concentration Pathways (RCP4.5 and RCP8.5). The STICS model was used, with the default pea parameterization refined using data from two years of dedicated field experiments. Ideotypes were defined by combining STICS and the E-FAST sensitivity analysis method focusing on model parameters representing traits on which breeding programs are ongoing. Results showed that climate change is expected to decrease the productivity of current pea cultivars (up to -12.6%), and that increasing irrigation (to cope with the expected less favourable rainfall distribution) would not avoid yield losses. The proposed ideotypes, characterized by a shorter vegetative phase and by increased tolerance to high temperature, performed better than current varieties, providing higher yields (+4.5%) and reduced water consumption (-20%). For the first time, we demonstrated the suitability of STICS for ideotyping purposes and used a simulation model to define pea breeding strategies targeting future climate conditions

Evidence for methyl group transfer between the methyl-accepting chemotaxis proteins in Bacillus subtilis.

We present evidence for methyl (as methyl or methoxy) transfer from the methyl-accepting chemotaxis proteins H1 and possibly H3 of Bacillus subtilis to the methyl-accepting chemotaxis protein H2. This methyl transfer, which has been observed in vitro (D. J. Goldman and G. W. Ordal, Biochemistry 23:2600-2606, 1984), was strongly stimulated by the chemoattractant aspartate and thus may play an important role in the sensory processing system of this organism. Although radiolabeling of H1 and H3 began at once after the addition of [3H]methionine, radiolabeling of H2 showed a lag. Furthermore, the addition of excess nonradioactive methionine caused immediate exponential delabeling of H1 and H3 while labeling of H2 continued to increase. Methylation of H2 required the chemotactic methyltransferase, probably to first methylate H1 and H3. Aspartate caused increased labeling of H2 and strongly decreased labeling of H1 and H3 after the addition of nonradioactive methionine. Without the addition of nonradioactive methionine, aspartate caused demethylation of H1 and to a lesser extent H3, with an approximately equal increase of methylation of H2

Detection of Temper Embrittlement in Steels using Magnetic Inspection Methods

This paper reports on a series of investigations of the effects of temper embrittlement on the magnetic properties of three different groups of steels. The objective of the work was to determine whether temper embrittlement caused any significant changes in the bulk magnetic properties and whether these changes could be incorporated into a nondestructive evaluation technique for assessment of temper embrittlement.</p

Intervenciones clinicas basadas en la psicologia positiva: Fundamentos y applicaciones (Clinical interventions based in positive psychology: Fundamentals and application) (in Spanish)

This paper reports on a series of investigations of the effects of temper embrittlement on the magnetic properties of three different groups of steels. The objective of the work was to determine whether temper embrittlement caused any significant changes in the bulk magnetic properties and whether these changes could be incorporated into a nondestructive evaluation technique for assessment of temper embrittlement