39 research outputs found
The helium trimer with soft-core potentials
The helium trimer is studied using two- and three-body soft-core potentials.
Realistic helium-helium potentials present an extremely strong short-range
repulsion and support a single, very shallow, bound state. The description of
systems with more than two helium atoms is difficult due to the very large
cancellation between kinetic and potential energy. We analyze the possibility
of describing the three helium system in the ultracold regime using a gaussian
representation of a widely used realistic potential, the LM2M2 interaction.
However, in order to describe correctly the trimer ground state a three-body
force has to be added to the gaussian interaction. With this potential model
the two bound states of the trimer and the low energy scattering helium-dimer
phase shifts obtained with the LM2M2 potential are well reproduced.Comment: 15 pages, 3 figures, submitted to Few-Body System
The potential utility of B cell-directed biologic therapy in autoimmune diseases
Increasing awareness of the importance of aberrant B cell regulation in autoimmunity has driven the clinical development of novel B cell-directed biologic therapies with the potential to treat a range of autoimmune disorders. The first of these drugsârituximab, a chimeric monoclonal antibody against the B cell-specific surface marker CD20âwas recently approved for treating rheumatoid arthritis in patients with an inadequate response to other biologic therapies. The aim of this review is to discuss the potential use of rituximab in the management of other autoimmune disorders. Results from early phase clinical trials indicate that rituximab may provide clinical benefit in systemic lupus erythematosus, SjĂśgrenâs syndrome, vasculitis, and thrombocytopenic purpura. Numerous case reports and several small pilot studies have also been published reporting the use of rituximab in conditions such as myositis, antiphospholipid syndrome, Stillâs disease, and multiple sclerosis. In general, the results from these preliminary studies encourage further testing of rituximab therapy in formalized clinical trials. Based on results published to date, it is concluded that rituximab, together with other B cell-directed therapies currently under clinical development, is likely to provide an important new treatment option for a number of these difficult-to-treat autoimmune disorders
Coherent reflection of he atom beams from rough surfaces at grazing incidence
Contains fulltext :
99077.pdf (preprint version ) (Open Access
Quantum reflection of he-2 several nanometers above a grating surface
Contains fulltext :
98946.pdf (publisher's version ) (Closed access