2,440 research outputs found
Typical medullary breast carcinoma: clinical outcomes and treatment results
Typical medullary breast carcinoma (T-MBC) accounts for less than 1% of all malignant breast neoplasms, and immunohistochemically is characteristic of “triple-negative” breast carcinoma. The purpose of this study was to describe the clinical characteristics and treatment results for patients with T-MBC treated at a single institution, and discuss the controversial aspects of this very rare form of breast cancer. Analyses was performed in 120 patients with T-MBC who were treated between 1970 and 2005. These cases represent 1.1% of all (11 270) patients treated for breast cancer during this period. According to TNM classification, 26 patients (21.6%) were in stage I, 80 patients (66.7%) in stage II and 14 (11.7%) in stage III of clinically advanced breast cancer. Involved axillary lymph nodes occurred in just 10 (8.3%) of the patients, and in all cases metastases were observed in 1–3 lymph nodes. All the patients underwent primary surgery. Radical mastectomies were performed on 98 (81.6%) patients, while the other 22 (18.4%) underwent breast-conserving surgery (BCS). Radiotherapy was performed in 36 patients (22 after BCS and 14 after mastectomy). Patients with nodal involvement (10 patients) received adjuvant chemotherapy, and 8 patients with hormone receptor expression received hormonotherapy with tamoxifen. The 10-year DFS rate was 90%. Out of 120 patients with T-MBC, only 4 (3.3%) died from this cancer. We showed that none of the population, neither clinical nor microscopic, had a statistically significant influence on the 10-year disease-free survival rate. Our results are similar to others presented in literature
Typical medullary breast carcinoma: clinical outcomes and treatment results
Typical medullary breast carcinoma (T-MBC) accounts for less than 1% of all malignant breast neoplasms, and immunohistochemically is characteristic of “triple-negative” breast carcinoma. The purpose of this study was to describe the clinical characteristics and treatment results for patients with T-MBC treated at a single institution, and discuss the controversial aspects of this very rare form of breast cancer. Analyses was performed in 120 patients with T-MBC who were treated between 1970 and 2005. These cases represent 1.1% of all (11 270) patients treated for breast cancer during this period. According to TNM classification, 26 patients (21.6%) were in stage I, 80 patients (66.7%) in stage II and 14 (11.7%) in stage III of clinically advanced breast cancer. Involved axillary lymph nodes occurred in just 10 (8.3%) of the patients, and in all cases metastases were observed in 1–3 lymph nodes. All the patients underwent primary surgery. Radical mastectomies were performed on 98 (81.6%) patients, while the other 22 (18.4%) underwent breast-conserving surgery (BCS). Radiotherapy was performed in 36 patients (22 after BCS and 14 after mastectomy). Patients with nodal involvement (10 patients) received adjuvant chemotherapy, and 8 patients with hormone receptor expression received hormonotherapy with tamoxifen. The 10-year DFS rate was 90%. Out of 120 patients with T-MBC, only 4 (3.3%) died from this cancer. We showed that none of the population, neither clinical nor microscopic, had a statistically significant influence on the 10-year disease-free survival rate. Our results are similar to others presented in literature
The Development of Cortical Responses to the Integration of Audiovisual Speech in Infancy
In adults, the integration of audiovisual speech elicits specific higher (super-additive) or lower (sub-additive) cortical responses when compared to the responses to unisensory stimuli. Although there is evidence that the fronto-temporal network is active during perception of audiovisual speech in infancy, the development of fronto-temporal responses to audiovisual integration remains unknown. In the current study, 5-month-olds and 10-month-olds watched bimodal (audiovisual) and alternating unimodal (auditory + visual) syllables. In this context we use alternating unimodal to denote alternating auditory and visual syllables that are perceived as separate syllables by adults. Using fNIRS we measured responses over large cortical areas including the inferior frontal and superior temporal regions. We identified channels showing different responses to bimodal than alternating unimodal condition and used multivariate pattern analysis (MVPA) to decode patterns of cortical responses to bimodal (audiovisual) and alternating unimodal (auditory + visual) speech. Results showed that in both age groups integration elicits cortical responses consistent with both super- and sub-additive responses in the fronto-temporal cortex. The univariate analyses revealed that between 5 and 10 months spatial distribution of these responses becomes increasingly focal. MVPA correctly classified responses at 5 months, with key input from channels located in the inferior frontal and superior temporal channels of the right hemisphere. However, MVPA classification was not successful at 10 months, suggesting a potential cortical re-organisation of audiovisual speech perception at this age. These results show the complex and non-gradual development of the cortical responses to integration of congruent audiovisual speech in infancy
The STAR Silicon Strip Detector (SSD)
The STAR Silicon Strip Detector (SSD) completes the three layers of the
Silicon Vertex Tracker (SVT) to make an inner tracking system located inside
the Time Projection Chamber (TPC). This additional fourth layer provides two
dimensional hit position and energy loss measurements for charged particles,
improving the extrapolation of TPC tracks through SVT hits. To match the high
multiplicity of central Au+Au collisions at RHIC the double sided silicon strip
technology was chosen which makes the SSD a half million channels detector.
Dedicated electronics have been designed for both readout and control. Also a
novel technique of bonding, the Tape Automated Bonding (TAB), was used to
fullfill the large number of bounds to be done. All aspects of the SSD are
shortly described here and test performances of produced detection modules as
well as simulated results on hit reconstruction are given.Comment: 11 pages, 8 figures, 1 tabl
Two-kaon correlations in central Pb + Pb collisions at 158 A GeV/c
Two-particle interferometry of positive kaons is studied in Pb + Pb
collisions at mean transverse momenta and 0.91 GeV/c. A
three-dimensional analysis was applied to the lower data, while a
two-dimensional analysis was used for the higher data. We find that the
source size parameters are consistent with the scaling curve observed in
pion correlation measurements in the same collisions, and that the duration
time of kaon emission is consistent with zero within the experimental
sensitivity.Comment: 4 pages incl. 1 table and 3 fig's; RevTeX; accepted for publication
in PR
Two-Proton Correlations near Midrapidity in p+Pb and S+Pb Collisions at the CERN SPS
Correlations of two protons emitted near midrapidity in p+Pb collisions at
450 GeV/c and S+Pb collisions at 200A GeV/c are presented, as measured by the
NA44 Experiment. The correlation effect, which arises as a result of final
state interactions and Fermi-Dirac statistics, is related to the space-time
characteristics of proton emission. The measured source sizes are smaller than
the size of the target lead nucleus but larger than the sizes of the
projectiles. A dependence on the collision centrality is observed; the source
size increases with decreasing impact parameter. Proton source sizes near
midrapidity appear to be smaller than those of pions in the same interactions.
Quantitative agreement with the results of RQMD (v1.08) simulations is found
for p+Pb collisions. For S+Pb collisions the measured correlation effect is
somewhat weaker than that predicted by the model simulations, implying either a
larger source size or larger contribution of protons from long-lived particle
decays.Comment: 10 pages (LaTeX) text, 4 (EPS) figures; accepted for publication in
Phys. Lett.
Strange Meson Enhancement in PbPb Collisions
The NA44 Collaboration has measured yields and differential distributions of
K+, K-, pi+, pi- in transverse kinetic energy and rapidity, around the
center-of-mass rapidity in 158 A GeV/c Pb+Pb collisions at the CERN SPS. A
considerable enhancement of K+ production per pi is observed, as compared to
p+p collisions at this energy. To illustrate the importance of secondary hadron
rescattering as an enhancement mechanism, we compare strangeness production at
the SPS and AGS with predictions of the transport model RQMD.Comment: 11 pages, including 4 figures, LATE
Phase-space dependence of particle-ratio fluctuations in Pb+Pb collisions from 20A to 158A GeV beam energy
A novel approach, the identity method, was used for particle identification
and the study of fluctuations of particle yield ratios in Pb+Pb collisions at
the CERN Super Proton Synchrotron (SPS). This procedure allows to unfold the
moments of the unknown multiplicity distributions of protons (p), kaons (K),
pions () and electrons (e). Using these moments the excitation function of
the fluctuation measure [A,B] was measured, with A and
B denoting different particle types. The obtained energy dependence of
agrees with previously published NA49 results on the related
measure . Moreover, was found to depend
on the phase space coverage for [K,p] and [K,] pairs. This feature most
likely explains the reported differences between measurements of NA49 and those
of STAR in central Au+Au collisions
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