4,051 research outputs found
Electronic Properties of Strained Si/Ge Core-Shell Nanowires
We investigated the electronic properties of strained Si/Ge core-shell
nanowires along the [110] direction using first principles calculations based
on density-functional theory. The diameter of the studied core-shell wire is up
to 5 nm. We found the band gap of the core-shell wire is smaller than that of
both pure Si and Ge wires with the same diameter. This reduced band gap is
ascribed to the intrinsic strain between Ge and Si layers, which partially
counters the quantum confinement effect. The external strain is further applied
to the nanowires for tuning the band structure and band gap. By applying
sufficient tensile strain, we found the band gap of Si-core/Ge-shell nanowire
with diameter larger than ~3 nm experiences a transition from direct to
indirect gap.Comment: 4 figure
A trans-diagnostic perspective on obsessive-compulsive disorder
© Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Progress in understanding the underlying neurobiology of obsessive-compulsive disorder (OCD) has stalled in part because of the considerable problem of heterogeneity within this diagnostic category, and homogeneity across other putatively discrete, diagnostic categories. As psychiatry begins to recognize the shortcomings of a purely symptom-based psychiatric nosology, new data-driven approaches have begun to be utilized with the goal of solving these problems: specifically, identifying trans-diagnostic aspects of clinical phenomenology based on their association with neurobiological processes. In this review, we describe key methodological approaches to understanding OCD from this perspective and highlight the candidate traits that have already been identified as a result of these early endeavours. We discuss how important inferences can be made from pre-existing case-control studies as well as showcasing newer methods that rely on large general population datasets to refine and validate psychiatric phenotypes. As exemplars, we take 'compulsivity' and 'anxiety', putatively trans-diagnostic symptom dimensions that are linked to well-defined neurobiological mechanisms, goal-directed learning and error-related negativity, respectively. We argue that the identification of biologically valid, more homogeneous, dimensions such as these provides renewed optimism for identifying reliable genetic contributions to OCD and other disorders, improving animal models and critically, provides a path towards a future of more targeted psychiatric treatments.Peer reviewedFinal Published versio
Spatiotemporal mode-locking in multimode fiber lasers
A laser is based on the electromagnetic modes of its resonator, which
provides the feedback required for oscillation. Enormous progress has been made
in controlling the interactions of longitudinal modes in lasers with a single
transverse mode. For example, the field of ultrafast science has been built on
lasers that lock many longitudinal modes together to form ultrashort light
pulses. However, coherent superposition of many longitudinal and transverse
modes in a laser has received little attention. The multitude of disparate
frequency spacings, strong dispersions, and complex nonlinear interactions
among modes greatly favor decoherence over the emergence of order. Here we
report the locking of multiple transverse and longitudinal modes in fiber
lasers to generate ultrafast spatiotemporal pulses. We construct multimode
fiber cavities using graded-index multimode fiber (GRIN MMF). This causes
spatial and longitudinal mode dispersions to be comparable. These dispersions
are counteracted by strong intracavity spatial and spectral filtering. Under
these conditions, we achieve spatiotemporal, or multimode (MM), mode-locking. A
variety of other multimode nonlinear dynamical processes can also be observed.
Multimode fiber lasers thus open new directions in studies of three-dimensional
nonlinear wave propagation. Lasers that generate controllable spatiotemporal
fields, with orders-of-magnitude increases in peak power over existing designs,
should be possible. These should increase laser utility in many established
applications and facilitate new ones
Orbital Parameter Determination for Wide Stellar Binary Systems in the Age of Gaia
The orbits of binary stars and planets, particularly eccentricities and
inclinations, encode the angular momentum within these systems. Within stellar
multiple systems, the magnitude and (mis)alignment of angular momentum vectors
among stars, disks, and planets probes the complex dynamical processes guiding
their formation and evolution. The accuracy of the \textit{Gaia} catalog can be
exploited to enable comparison of binary orbits with known planet or disk
inclinations without costly long-term astrometric campaigns. We show that
\textit{Gaia} astrometry can place meaningful limits on orbital elements in
cases with reliable astrometry, and discuss metrics for assessing the
reliability of \textit{Gaia} DR2 solutions for orbit fitting. We demonstrate
our method by determining orbital elements for three systems (DS Tuc AB, GK/GI
Tau, and Kepler-25/KOI-1803) using \textit{Gaia} astrometry alone. We show that
DS Tuc AB's orbit is nearly aligned with the orbit of DS Tuc Ab, GK/GI Tau's
orbit might be misaligned with their respective protoplanetary disks, and the
Kepler-25/KOI-1803 orbit is not aligned with either component's transiting
planetary system. We also demonstrate cases where \textit{Gaia} astrometry
alone fails to provide useful constraints on orbital elements. To enable
broader application of this technique, we introduce the python tool
\texttt{lofti\_gaiaDR2} to allow users to easily determine orbital element
posteriors.Comment: 18 pages, 10 figures, accepted for publication in Ap
Field-dependent dynamics of the Anderson impurity model
Single-particle dynamics of the Anderson impurity model in the presence of a
magnetic field are considered, using a recently developed local moment
approach that encompasses all energy scales, field and interaction strengths.
For strong coupling in particular, the Kondo scaling regime is recovered. Here
the frequency () and field ()
dependence of the resultant universal scaling spectrum is obtained in large
part analytically, and the field-induced destruction of the Kondo resonance
investigated. The scaling spectrum is found to exhibit the slow logarithmic
tails recently shown to dominate the zero-field scaling spectrum. At the
opposite extreme of the Fermi level, it gives asymptotically exact agreement
with results for statics known from the Bethe ansatz. Good agreement is also
found with the frequency and field-dependence of recent numerical
renormalization group calculations. Differential conductance experiments on
quantum dots in the presence of a magnetic field are likewise considered; and
appear to be well accounted for by the theory. Some new exact results for the
problem are also established
Strain Modulated Electronic Properties of Ge Nanowires - A First Principles Study
We used density-functional theory based first principles simulations to study
the effects of uniaxial strain and quantum confinement on the electronic
properties of germanium nanowires along the [110] direction, such as the energy
gap and the effective masses of the electron and hole. The diameters of the
nanowires being studied are up to 50 {\AA}. As shown in our calculations, the
Ge [110] nanowires possess a direct band gap, in contrast to the nature of an
indirect band gap in bulk. We discovered that the band gap and the effective
masses of charge carries can be modulated by applying uniaxial strain to the
nanowires. These strain modulations are size-dependent. For a smaller wire (~
12 {\AA}), the band gap is almost a linear function of strain; compressive
strain increases the gap while tensile strain reduces the gap. For a larger
wire (20 {\AA} - 50 {\AA}), the variation of the band gap with respect to
strain shows nearly parabolic behavior: compressive strain beyond -1% also
reduces the gap. In addition, our studies showed that strain affects effective
masses of the electron and hole very differently. The effective mass of the
hole increases with a tensile strain while the effective mass of the electron
increases with a compressive strain. Our results suggested both strain and size
can be used to tune the band structures of nanowires, which may help in design
of future nano-electronic devices. We also discussed our results by applying
the tight-binding model.Comment: 1 table, 8 figure
Local quantum phase transition in the pseudogap Anderson model: scales, scaling and quantum critical dynamics
The pseudogap Anderson impurity model provides a paradigm for understanding
local quantum phase transitions, in this case between generalised fermi liquid
and degenerate local moment phases. Here we develop a non-perturbative local
moment approach to the generic asymmetric model, encompassing all energy scales
and interaction strengths and leading thereby to a rich description of the
problem. We investigate in particular underlying phase boundaries, the critical
behaviour of relevant low-energy scales, and single-particle dynamics embodied
in the local spectrum. Particular attention is given to the resultant universal
scaling behaviour of dynamics close to the transition in both the GFL and LM
phases, the scale-free physics characteristic of the quantum critical point
itself, and the relation between the two.Comment: 39 pages, 19 figure
Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?
Original article can be found at: http://journals.cambridge.org/ Copyright © Cambridge University Press 2009 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>.Background: Obsessive-compulsive disorder (OCD) has been associated with impairments in stop-signal inhibition, a measure of motor response suppression. The study used a novel paradigm to examine both thought suppression and response inhibition in OCD, where the modulatory effects of stimuli relevant to OCD could also be assessed. Additionally, the study compared inhibitory impairments in OCD patients with and without co-morbid depression, as depression is the major co-morbidity of OCD. Method: Volitional response suppression and unintentional thought suppression to emotive and neutral stimuli were examined using a novel thought stop-signal task. The thought stop-signal task was administered to non-depressed OCD patients, depressed OCD patients and healthy controls (n=20 per group). Results: Motor inhibition impairments were evident in OCD patients, while motor response performance did not differ between patients and controls. Switching to a new response but not motor inhibition was affected by stimulus relevance in OCD patients. Additionally, unintentional thought suppression as measured by repetition priming was intact. OCD patients with and without depression did not differ on any task performance measures, though there were significant differences in all self-reported measures. Conclusions: Results support motor inhibition deficits in OCD that remain stable regardless of stimulus meaning or co-morbid depression. Only switching to a new response was influenced by stimulus meaning. When response inhibition was successful in OCD patients, so was the unintentional suppression of the accompanying thought.Peer reviewe
Decreased dopamine activity predicts relapse in methamphetamine abusers.
Studies in methamphetamine (METH) abusers showed that the decreases in brain dopamine (DA) function might recover with protracted detoxification. However, the extent to which striatal DA function in METH predicts recovery has not been evaluated. Here we assessed whether striatal DA activity in METH abusers is associated with clinical outcomes. Brain DA D2 receptor (D2R) availability was measured with positron emission tomography and [(11)C]raclopride in 16 METH abusers, both after placebo and after challenge with 60 mg oral methylphenidate (MPH) (to measure DA release) to assess whether it predicted clinical outcomes. For this purpose, METH abusers were tested within 6 months of last METH use and then followed up for 9 months of abstinence. In parallel, 15 healthy controls were tested. METH abusers had lower D2R availability in caudate than in controls. Both METH abusers and controls showed decreased striatal D2R availability after MPH and these decreases were smaller in METH than in controls in left putamen. The six METH abusers who relapsed during the follow-up period had lower D2R availability in dorsal striatum than in controls, and had no D2R changes after MPH challenge. The 10 METH abusers who completed detoxification did not differ from controls neither in striatal D2R availability nor in MPH-induced striatal DA changes. These results provide preliminary evidence that low striatal DA function in METH abusers is associated with a greater likelihood of relapse during treatment. Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes
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