Specific SPS construction studies: Construction tasks, construction base

A concept for building the 5000 MW reference solar power satellite in Earth orbit is discussed. The system uses silicon solar cells. The GEO base has contiguous facilities for concurrent assembly and subsequent mating of the satellite energy conversion system and its power transmission antenna. The end builder construction system uses 10 synchronized beam machines to automatically fabricate continuous longitudinal beams for the energy conversion system

Epitaxial Y1Ba2Cu3O7 thin films on CeO2 buffer layers on sapphire substrates

Pulsed laser deposition has been used to deposit Y1Ba2Cu3O7 layer on CeO2 buffer layers on (1102) sapphire. Both layers are epitaxial with the (110) direction of the CeO2 layer aligned with the direction of the sapphire substrate. The c-axis Y1Ba2Cu3O7 layer has its direction aligned with the direction of the CeO2. Cross-sectional transmission electron microscopy shows the epitaxy to be coherent and the interfaces to be abrupt at an atomic level. The best films have a critical current of 9 e6 A/cm2 at 4.2 K and lower microwave surface resistance than copper at 77 K and at a frequency of 31 GHz.Comment: 3 pages, 2 figures, journal articl

Short length-scale variability of hybrid event beds and its applied significance

Hybrid event beds (HEBs) are a type of deep-water sediment gravity flow deposit that generally comprise a basal clean sandstone overlain by a variety of muddier and less-permeable sandy facies. They are thought to be emplaced by combinations of turbidity currents, transitional flows and debris flows, all as part of the same transport event. To date, a number of studies have highlighted the common presence of HEBs mainly in the outer and marginal parts of deep-water systems where they replace beds composed dominantly of clean sand up-dip and/or axially over scales of km to 10s km. In addition to these broad patterns, important yet poorly understood short-length facies changes (over metres to 100s m) occur, modifying the overall texture and reservoir characteristics at or beneath typical spacing of production wells. The nature and origin of the short length-scale transitions is here addressed in four well-exposed HEB-prone outcrops: the Cretaceous-Paleocene Gottero Sandstone and the Miocene Cilento Flysch, both in Italy, the Carboniferous Mam Tor Sandstone in northern England, and the Carboniferous basal Ross Sandstone Formation, Western Ireland. A series of detailed correlation panels show marked lateral variations in internal bed make-up for most of the hybrid event beds studied. This variability typically involves lateral changes in the proportions of the cleaner basal sandstone and the overlying muddy sandstone division that occur without substantial change in the overall event bed thickness. The variability is inferred to reflect the complex fingering between the up-dip sandstone-dominated part of the event bed and the down-dip linked debrite due to internal erosion (ploughing) of the debrite into the basal clean sand. Where the upper part of the bed is dominated by large mudstone rafts, these may have foundered into liquefied sand and been injected and partly fragmented by the sand intrusions. The variable thickness and continuity of the basal clean sandstones have important implications for reservoir characterisation; significant variability in bed character at interwell scale can be anticipated. Rugose contacts between the intra-bed facies divisions may impact on drainage and sweep efficiency during hydrocarbon production

Regulation of NF-κB by PML and PML-RARα

Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting NF-κB activity. TNFα-treated PML−/− cells show normal IκBα degradation and NF-κB nuclear translocation but significantly reduced NF-κB DNA binding and phosphorylation of NF-κB p65. We also demonstrate that the PML retinoic acid receptor-α (PML-RARα) oncofusion protein, which causes acute promyelocytic leukemia, inhibits TNFα induced gene expression and phosphorylation of NF-κB. This study establishes PML as an important regulator of NF-κB and demonstrates that PML-RARα dysregulates NF-κB

"Isn't All of Oncology Hermeneutic?"

In this paper, we describe an event during a pediatric oncology research meeting that prompted the discussion of the ways in which hermeneutics brings a different kind of understanding to both research and practice. We claim that oncology is the practical science of handling natural science research and as such practice in oncology is deeply hermeneutic in character in its recognition of the importance, vitality, and generativity of the “individual case†even in the face of amassed, verified, and aggregate knowledge that is given from the natural science research. Oncology is always contingent, next case handling, and is not identifiable simply as something determined and guided by natural sciences alone. In the face of this, we propose that there is an obvious, profound, and natural fit of hermeneutic research in understanding the lives, relationships, suffering, and experiences that are affected by cancer.   Keywords: childhood cancer, Gadamer, hermeneutics, pediatric oncology, Robert Buckman Â

Practice variation in late-preterm deliveries: a physician survey

Objective: Late preterm (LPT) neonates account for over 70% of all preterm births in the US. Approximately 60% of LPT births are the result of non-spontaneous deliveries.The optimal timing of delivery for many obstetric conditions at LPT gestations is unclear, likely resulting in obstetric practice variation. The purpose of this study is to identify variation in the obstetrical management of LPT pregnancies. Study design: We surveyed obstetrical providers in NC identified from NC Medical Board and NC Obstetrical and Gynecological Society membership lists. Participants answered demographic questions and 6 multiple-choice vignettes on management of LPT pregnancies. Result: We obtained 215/859 (29%) completed surveys; 167 (78%) from Obstetrics/Gynecology, 27 (13%) from Maternal-Fetal Medicine, and 21 (10%) from Family Medicine physicians. Overall, we found more agreement on respondents’ management of chorioamnionitis (97% would proceed with delivery), mild preeclampsia (84% would delay delivery/expectantly manage), and fetal growth restriction (80% would delay delivery/expectantly manage). We found less agreement on the management of severe preeclampsia (71% would proceed with delivery), premature preterm rupture of membranes (69% would proceed with delivery), and placenta previa (67% would delay delivery/expectantly manage). Management of LPT pregnancies complicated by PPROM, FGR, and placenta previa vary by specialty. Conclusion: Obstetrical providers report practice variation in the management of LPT pregnancies. Variation might be influenced by provider specialty. The absence of widespread agreement on best practice might be a source of modifiable LPT birth

Mixing in density- and viscosity-stratified flows

The lock-exchange problem is used extensively to study the flow dynamics of density-driven flows, such as gravity currents, and as a canonical problem to mixing in stratified flows. Opposite halves of a domain are filled with two fluids of different densities and held in place by a lock-gate. Upon release, the density difference drives the flow causing the fluids to slosh back and forth. In many scenarios, density stratification will also impose a viscosity stratification (e.g., if there are suspended sediments or the two fluids are distinct). However, numerical models often neglect variable viscosity. This paper characterizes the effect of both density and viscosity stratification in the lock-exchange configuration. The governing Navier-Stokes equations are solved using direct numerical simulation. Three regimes are identified in terms of the viscosity ratio μ 2 / μ 1 = (1 + γ) between the dense and less dense fluids: when γ ≪ 1, the flow dynamics are similar to the equal-viscosity case; for intermediate values (γ ∼ 1), viscosity inhibits interface-scale mixing leading to a global reduction in mixing and enhanced transfer between potential and kinetic energy. Increasing the excess viscosity ratio further (γ ≫ 1) results in significant viscous dissipation. Although many gravity or turbidity current models assume constant viscosity, our results demonstrate that viscosity stratification can only be neglected when γ ≪ 1. The initial turbidity current composition could enhance its ability to become self-sustaining or accelerating at intermediate excess viscosity ratios. Currents with initially high excess viscosity ratio may be unable to dilute and propagate long distances because of the decreased mixing rates and increased dissipation

Pulse propagation in gravity currents

Real world gravity current flows rarely exist as a single discrete event, but are instead made up of multiple surges. This paper examines the propagation of surges as pulses in gravity currents. Using theoretical shallow-water modeling, we analyze the structure of pulsed flows created by the sequential release of two lock-boxes. The first release creates a gravity current, while the second creates a pulse that eventually propagates to the head of the first current. Two parameters determine the flow structure: the densimetric Froude number at the head of the current, Fr, and a dimensionless time between releases, tre. The shallow-water model enables the flow behavior to be mapped in (Fr, tre) space. Pulse speed depends on three critical characteristic curves: two that derive from the first release and correspond to a wavelike disturbance which reflects between the head of the current and the back of the lock-box and a third that originates from the second release and represents the region of the flow affected by the finite supply of source material. Pulses have non-negative acceleration until they intersect the third characteristic, after which they decelerate. Variations in pulse speed affect energy transfer and dissipation. Critically for lahars, landslides, and avalanches, pulsed flows may change from erosional to depositional, further affecting their dynamics. Gravity current hazard prediction models for such surge-prone flows may underpredict risk if they neglect internal flow dynamics