3,957 research outputs found
Effects of sex chromosome dosage on corpus callosum morphology in supernumerary sex chromosome aneuploidies.
BackgroundSupernumerary sex chromosome aneuploidies (sSCA) are characterized by the presence of one or more additional sex chromosomes in an individual's karyotype; they affect around 1 in 400 individuals. Although there is high variability, each sSCA subtype has a characteristic set of cognitive and physical phenotypes. Here, we investigated the differences in the morphometry of the human corpus callosum (CC) between sex-matched controls 46,XY (N =99), 46,XX (N =93), and six unique sSCA karyotypes: 47,XYY (N =29), 47,XXY (N =58), 48,XXYY (N =20), 47,XXX (N =30), 48,XXXY (N =5), and 49,XXXXY (N =6).MethodsWe investigated CC morphometry using local and global area, local curvature of the CC boundary, and between-landmark distance analysis (BLDA). We hypothesized that CC morphometry would vary differentially along a proposed spectrum of Y:X chromosome ratio with supernumerary Y karyotypes having the largest CC areas and supernumerary X karyotypes having significantly smaller CC areas. To investigate this, we defined an sSCA spectrum based on a descending Y:X karyotype ratio: 47,XYY, 46,XY, 48,XXYY, 47,XXY, 48,XXXY, 49,XXXXY, 46,XX, 47,XXX. We similarly explored the effects of both X and Y chromosome numbers within sex. Results of shape-based metrics were analyzed using permutation tests consisting of 5,000 iterations.ResultsSeveral subregional areas, local curvature, and BLDs differed between groups. Moderate associations were found between area and curvature in relation to the spectrum and X and Y chromosome counts. BLD was strongly associated with X chromosome count in both male and female groups.ConclusionsOur results suggest that X- and Y-linked genes have differential effects on CC morphometry. To our knowledge, this is the first study to compare CC morphometry across these extremely rare groups
Does Medicaid Make a Difference? Findings from the Commonwealth Fund Biennial Health Insurance Survey, 2014
As millions of Americans gain Medicaid coverage under the Affordable Care Act, attention has focused on the access to care, quality of care, and financial protection that coverage provides. This analysis uses the Commonwealth Fund Biennial Health Insurance Survey, 2014, to explore these questions by comparing the experiences of working-age adults with private insurance who were insured all year, Medicaid beneficiaries with a full year of coverage, and those who were uninsured for some time during the year. The survey findings suggest that Medicaid coverage provides access to care that in most aspects is comparable to private insurance. Adults with Medicaid coverage reported better care experiences on most measures than those who had been uninsured during the year. Medicaid beneficiaries also seem better protected from the cost of illness than do uninsured adults, as well as those with private coverage
Single-parameter non-adiabatic quantized charge pumping
Controlled charge pumping in an AlGaAs/GaAs gated nanowire by
single-parameter modulation is studied experimentally and theoretically.
Transfer of integral multiples of the elementary charge per modulation cycle is
clearly demonstrated. A simple theoretical model shows that such a quantized
current can be generated via loading and unloading of a dynamic quasi-bound
state. It demonstrates that non-adiabatic blockade of unwanted tunnel events
can obliterate the requirement of having at least two phase-shifted periodic
signals to realize quantized pumping. The simple configuration without multiple
pumping signals might find wide application in metrological experiments and
quantum electronics.Comment: 4 pages, 4 figure
Algebras generated by two bounded holomorphic functions
We study the closure in the Hardy space or the disk algebra of algebras
generated by two bounded functions, of which one is a finite Blaschke product.
We give necessary and sufficient conditions for density or finite codimension
of such algebras. The conditions are expressed in terms of the inner part of a
function which is explicitly derived from each pair of generators. Our results
are based on identifying z-invariant subspaces included in the closure of the
algebra. Versions of these results for the case of the disk algebra are given.Comment: 22 pages ; a number of minor mistakes have been corrected, and some
points clarified. Conditionally accepted by Journal d'Analyse Mathematiqu
Economic Analysis of Cellulosic Feedstock for Bioenergy in the Texas Rio Grande Valley
Farm Management,
Americans' Experiences in the Health Insurance Marketplaces: Results from The First Three Months
Conducted December 11â29, 2013, The Commonwealth Fund's second Affordable Care Act Tracking Survey interviewed a nationally representative sample of adults who are potentially eligible for the health reform law's new insurance options, whether private plans or Medicaid. Results show that by the end of December, 24 percent of potentially eligible adults had visited a marketplace to find a plan. The first survey, conducted in October, had found that 17 percent of people potentially eligible for coverage had visited the marketplaces during the first month of open enrollment. By the end of December, 41 percent of visitors were ages 19 to 34, and 77 percent reported being in good health. People's ability to compare benefits and premiums improved between October and December, but many reported challenges in plan selection. A majority of respondents say they are determined to gain coverage by the end of this year's open enrollment period
Inverse Compton Scattering as the Source of Diffuse EUV Emission in the Coma Cluster of Galaxies
We have examined the hypothesis that the majority of the diffuse EUV flux in
the Coma cluster is due to inverse Compton scattering of low energy cosmic ray
electrons (0.16 < epsilon < 0.31 GeV) against the 3K black-body background. We
present data on the two-dimensional spatial distribution of the EUV flux and
show that these data provide strong support for a non-thermal origin for the
EUV flux. However, we show that this emission cannot be produced by an
extrapolation to lower energies of the observed synchrotron radio emitting
electrons and an additional component of low energy cosmic ray electrons is
required.Comment: 11 pages, 5 figure
The Role of a Hot Gas Environment on the Evolution of Galaxies
Most spiral galaxies are found in galaxy groups with low velocity
dispersions; most E/S0 galaxies are found in galaxy groups with relatively high
velocity dispersions. The mass of the hot gas we can observe in the E/S0 groups
via their thermal X-ray emission is, on average, as much as the baryonic mass
of the galaxies in these groups. By comparison, galaxy clusters have as much or
more hot gas than stellar mass. Hot gas in S-rich groups, however, is of low
enough temperature for its X-ray emission to suffer heavy absorption due to
Galactic HI and related observational effects, and hence is hard to detect. We
postulate that such lower temperature hot gas does exist in low velocity
dispersion, S-rich groups, and explore the consequences of this assumption. For
a wide range of metallicity and density, hot gas in S-rich groups can cool in
far less than a Hubble time. If such gas exists and can cool, especially when
interacting with HI in existing galaxies, then it can help link together a
number of disparate observations, both Galactic and extragalactic, that are
otherwise difficult to understand.Comment: 16 pages with one figure. ApJ Letters, in pres
On -transforms of one-dimensional diffusions stopped upon hitting zero
For a one-dimensional diffusion on an interval for which 0 is the
regular-reflecting left boundary, three kinds of conditionings to avoid zero
are studied. The limit processes are -transforms of the process stopped
upon hitting zero, where 's are the ground state, the scale function, and
the renormalized zero-resolvent. Several properties of the -transforms are
investigated
A depression before a bump in the highest energy cosmic ray spectrum
We re-examine the interaction of ultra high energy nuclei with the microwave
background radiation. We find that the giant dipole resonance leaves a new
signature in the differential energy spectrum of iron sources located around 3
Mpc: A depression before the bump which is followed by the expected cutoff.Comment: revisited version, 5 pages RevTex, 5 figure
- âŠ