504 research outputs found
Estimation of Input-Output Coefficients Using Neoclassical Production Theory
The aim of this paper is to combine well-known theoretical approaches from the theory of production and to apply them to a data base drawn up within the framework of modern input-output statistics. The changes in I/O coefficients observed for the Canadian basic metal industry are attributed to changes in microtechnologies brought about by shifts in the relative prices and the output structure of this industry
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy – Lessons for management
Abstract
Background
Malignant struma ovarii is an ovarian teratoma containing at least 50% thyroid tissue which has the potential to metastasize and produce thyroid hormone. Given its rarity, management strategies are not well-established. We report a case of metastatic malignant struma ovarii discovered during pregnancy with lessons for evaluation and management.
Case presentation
A 30-year-old woman who was two months pregnant was discovered to have struma ovarii with over half of the struma comprised of papillary thyroid cancer. Following tumor resection, delivery, and thyroidectomy, she underwent evaluation with stimulated thyroglobulin testing and diagnostic staging sodium iodide-131 scan (I-131), which revealed the presence of skeletal metastases. Following administration of 320 mCi I-131, post-therapy scan also showed miliary pulmonary metastases with improved ability to localize the bony and pulmonary metastases with concurrent SPECT/CT imaging. A second dosimetry-guided I-131 therapy resulted in complete resolution of pulmonary metastases; however, small foci of residual bone disease persisted. Post-therapy scans demonstrated additional findings not shown on diagnostic I-131 scans obtained prior to both her initial and second I-131 therapy.
Conclusions
SPECT/CT provides accurate anatomic correlation and localization of metastatic foci and can serve as a baseline study to assess interval response to treatment. Post-therapy scans should always be obtained when I-131 treatment is administered, as additional findings may be revealed versus low dose I-131 activity diagnostic scans. This patient had a high metastatic burden that would not have been discovered in a timely fashion with the conservative approach advocated by others. Thyroidectomy followed by a diagnostic staging radioiodine scan and a stimulated thyroglobulin level should be considered in patients with malignant struma ovarii for guiding therapeutic I-131 administration as metastatic risk is difficult to predict based on histopathologic examination.https://deepblue.lib.umich.edu/bitstream/2027.42/144518/1/40842_2018_Article_64.pd
In-Depth Global Analysis of Transcript Abundance Levels in Porcine Alveolar Macrophages Following Infection with Porcine Reproductive and Respiratory Syndrome Virus
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen of swine worldwide and causes considerable economic loss. Identifying specific cell signaling or activation pathways that associate with variation in PRRSV replication and macrophage function may lead to identification of novel gene targets for the control of PRRSV infection. Serial Analysis of Gene Expression (SAGE) was used to create and survey the transcriptome of in vitro mock-infected and PRRSV strain VR-2332-infected porcine alveolar macrophages (PAM) at 0, 6, 12, 16, and 24 hours after infection. The transcriptome data indicated changes in transcript abundance occurring in PRRSV-infected PAMs over time after infection with more than 590 unique tags with significantly altered transcript abundance levels identified (P < .01). Strikingly, innate immune genes (whose transcript abundances are typically altered in response to other pathogens or insults including IL-8, CCL4, and IL-1β) showed no or very little change at any time point following infection
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Artifical intelligence techniques for tuning linear induction accelerators
We developed an expert system that acts as an intelligent assistant for tuning particle beam generators called MAESTRO, Model and Expert System Resource for Operators. MAESTRO maintains a knowledge base of the accelerator containing not only the interconnections of the beamline components, but also their physical attributes such as measured magnetic tilts, offsets, and field profiles. MAESTRO incorporates particle trajectory and beam envelope models which are coupled to the knowledge base permitting large numbers of real-time orbit and envelope calculations in the control-room environment. To date we have used this capability in three ways: First, to implement a tuning algorithm for minimizing transverse beam motion. Second, to produce a beam waist with arbitrary radius at the entrance to a brightness diagnostic. And finally, to measure beam energy along the accelerator by fitting orbits to focusing and steering sweeps
Convective Term and Transversely Driven Charge-Density Waves
We derive the convective terms in the damping which determine the structure
of the moving charge-density wave (CDW), and study the effect of a current
flowing transverse to conducting chains on the CDW dynamics along the chains.
In contrast to a recent prediction we find that the effect is orders of
magnitude smaller, and that contributions from transverse currents of electron-
and hole-like quasiparticles to the force exerted on the CDW along the chains
act in the opposite directions. We discuss recent experimental verification of
the effect and demonstrate experimentally that geometry effects might mimic the
transverse current effect.Comment: RevTeX, 9 pages, 1 figure, accepted for publications in PR
Dynamic inundation simulation of storm water interaction between sewer system and overland flows
Copyright © 2002 Taylor & FrancisThis is the Author's Accepted Manuscript of an article published in the Journal of the Chinese Institute of Engineers (2002), available online at: http://www.tandfonline.com/10.1080/02533839.2002.9670691An improved urban inundation model, coupling a 2D non‐inertia overland flow model with a storm water management model, is adopted to simulate inundation in urban areas. The model computes, not only the overland runoff and the water overflow through manholes where surface runoff exceeds the capacity of storm sewers, but also the bidirectional flow interactions between sewers and overland runoff. The model was verified by a typhoon event in Nov. 2000, which resulted in serious inundation in the Mucha area of Taipei City. The result shows that the present model indeed improves simulation accuracy over the earlier model, and can be used to provide a more reliable flood mitigation design
Association between labour market trends and trends in young people's mental health in ten European countries 1983-2005
<p>Abstract</p> <p>Background</p> <p>Mental health problems have become more common among young people over the last twenty years, especially in certain countries. The reasons for this have remained unclear. The hypothesis tested in this study is that national trends in young people's mental health are associated with national trends in young people's labour market.</p> <p>Methods</p> <p>National secular changes in the proportion of young people with mental health problems and national secular labour market changes were studied from 1983 to 2005 in Austria, Belgium, Denmark, Finland, Hungary, Norway, Spain, Sweden, Switzerland and the United Kingdom.</p> <p>Results</p> <p>The correlation between the national secular changes in the proportion of young people not in the labour force and the national secular changes in proportion of young people with mental health symptoms was 0.77 for boys and 0.92 for girls.</p> <p>Conclusion</p> <p>Labour market trends may have contributed to the deteriorating trend in mental health among young people. A true relationship, should other studies confirm it, would be an important aspect to take into account when forming labour market policies or policies concerning the delivery of higher education.</p
Reaction Time and Mortality from the Major Causes of Death:The NHANES-III Study
Studies examining the relation of information processing speed, as measured by reaction time, with mortality are scarce. We explored these associations in a representative sample of the US population
Standard and Embedded Solitons in Nematic Optical Fibers
A model for a non-Kerr cylindrical nematic fiber is presented. We use the
multiple scales method to show the possibility of constructing different kinds
of wavepackets of transverse magnetic (TM) modes propagating through the fiber.
This procedure allows us to generate different hierarchies of nonlinear partial
differential equations (PDEs) which describe the propagation of optical pulses
along the fiber. We go beyond the usual weakly nonlinear limit of a Kerr medium
and derive an extended Nonlinear Schrodinger equation (eNLS) with a third order
derivative nonlinearity, governing the dynamics for the amplitude of the
wavepacket. In this derivation the dispersion, self-focussing and diffraction
in the nematic are taken into account. Although the resulting nonlinear
may be reduced to the modified Korteweg de Vries equation (mKdV), it also has
additional complex solutions which include two-parameter families of bright and
dark complex solitons. We show analytically that under certain conditions, the
bright solitons are actually double embedded solitons. We explain why these
solitons do not radiate at all, even though their wavenumbers are contained in
the linear spectrum of the system. Finally, we close the paper by making
comments on the advantages as well as the limitations of our approach, and on
further generalizations of the model and method presented.Comment: "Physical Review E, in press
Identifying specific causes of kidney allograft loss
The causes of kidney allograft loss remain unclear. Herein we investigated these causes in 1317 conventional kidney recipients. The cause of graft loss was determined by reviewing clinical and histologic information the latter available in 98% of cases. During 50.3 ± 32.6 months of follow-up, 330 grafts were lost (25.0%), 138 (10.4%) due to death with function, 39 (2.9%) due to primary nonfunction and 153 (11.6%) due to graft failure censored for death. The latter group was subdivided by cause into: glomerular diseases (n = 56, 36.6%); fibrosis/atrophy (n = 47, 30.7%); medical/surgical conditions (n = 25, 16.3%); acute rejection (n = 18, 11.8%); and unclassifiable (n = 7, 4.6%). Glomerular pathologies leading to failure included recurrent disease (n = 23), transplant glomerulopathy (n = 23) and presumed nonrecurrent disease (n = 10). In cases with fibrosis/atrophy a specific cause(s) was identified in 81% and it was rarely attributable to calcineurin inhibitor (CNI) toxicity alone (n = 1, 0.7%). Contrary to current concepts, most cases of kidney graft loss have an identifiable cause that is not idiopathic fibrosis/atrophy or CNI toxicity. Glomerular pathologies cause the largest proportion of graft loss and alloinmunity remains the most common mechanism leading to failure. This study identifies targets for investigation and intervention that may result in improved kidney transplantation outcomes
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