2,962 research outputs found
High-temperature, zero-drop thyratron tube program Quarterly progress report, 1 Apr. - 31 May 1966
High temperature zero drop thyratron tube for thermionic converter generato
Sigurjonsson v. Iceland: The European Court of Human Rights Expands the Negative Right of Association
Sigurjonsson v. Iceland: The European Court of Human Rights Expands the Negative Right of Association
Calibration of liquid argon and neon detectors with
We report results from tests of Kr, as a calibration
source in liquid argon and liquid neon. Kr atoms are
produced in the decay of Rb, and a clear Kr
scintillation peak at 41.5 keV appears in both liquids when filling our
detector through a piece of zeolite coated with Rb. Based on this
scintillation peak, we observe 6.0 photoelectrons/keV in liquid argon with a
resolution of 6% (/E) and 3.0 photoelectrons/keV in liquid neon with a
resolution of 19% (/E). The observed peak intensity subsequently decays
with the Kr half-life after stopping the fill, and we
find evidence that the spatial location of Kr atoms in
the chamber can be resolved. Kr will be a useful
calibration source for liquid argon and neon dark matter and solar neutrino
detectors.Comment: 7 pages, 12 figure
Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP1.
Heterogeneous upregulation of multiple prosurvival pathways underlies resistance to damage-induced apoptosis in acute lymphoblastic leukemia (ALL) cells despite normal p53 responses. Here, we show that the dual combination of insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1/R) and mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibition using AG1024 + U0126 can sensitize apoptosis-resistant ALL cells to ionizing radiation-induced DNA damage irrespective of effect of single pathway inhibition in vitro. This AG1024 + U0126 combination also significantly potentiates the ability of the core chemotherapy compounds vincristine, dexamethasone, and daunorubicin to kill ALL cells in vitro. Evidence of the synergistic action of AG1024 + U0126 in samples with variable basal levels of phosphorylated IGF1/Rβ and ERK1/2 suggested additional targets of this drug combination. Consistent with this, gene expression profiling identified 32 "synergy genes" differentially targeted by IGF1/R + MEK inhibition and, among these, Signal transducer and activator of transcription 6 (STAT6) and platelet-derived growth factor-associated protein 1 (PDAP1) were the most differentially downregulated cluster. Pearson correlation analyses revealed that STAT6 and PDAP1 display significant expression codependency and a common expression pattern linked with other key "synergy" genes, supporting their predicted role in an STAT6-ERK-nuclear factor kappa beta (NF-κB) network. Knockdown studies revealed that loss of STAT6, but not PDAP1, impinges on the cell cycle, causing reduced numbers of viable cells. In combination with daunorubicin, STAT6 loss has an additive effect on cell killing, whereas PDAP1 loss is synergistic, indicating an important role of PDAP1 in the cellular response to this anthracycline. Inhibition of STAT6 or PDAP1 may therefore represent a potential novel therapeutic strategy for resistant ALL by enhancing sensitivity to chemotherapy
Effects of mental imagery on free throw performance of varsity basketball players during practice and competition
The purpose of this study was to examine the effects of mental
imagery in practice and in competition on the free throw shooting
performance of basketball players. The subjects were 3 male
university caliber basketball players. A single subject multiple
baseline design was implemented. Each subject was introduced to the
imagery rehearsal intervention at different times during the 14 week
competitive basketball season. Free throw data was collected during
50 practice sessions and 32 games. Results in both practice and
competitive situations were examined using a graphed means
comparison. In the practice condition an increase in free throw
performance for all 3 subjects during the post treatment intervention
was found. In the game condition, Subjects A and B indicated post
treatment improvement. Mental imagery can be an effective strategy
to improve free throw performance of some basketball players.
Further research in this area should involve controlled group
examination using a larger sample size across a variety of tasks
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