AGC 226067: A possible interacting low-mass system

We present Arecibo, GBT, VLA and WIYN/pODI observations of the ALFALFA source AGC 226067. Originally identified as an ultra-compact high velocity cloud and candidate Local Group galaxy, AGC 226067 is spatially and kinematically coincident with the Virgo cluster, and the identification by multiple groups of an optical counterpart with no resolved stars supports the interpretation that this systems lies at the Virgo distance (D=17 Mpc). The combined observations reveal that the system consists of multiple components: a central HI source associated with the optical counterpart (AGC 226067), a smaller HI-only component (AGC 229490), a second optical component (AGC 229491), and extended low surface brightness HI. Only ~1/4 of the single-dish HI emission is associated with AGC 226067; as a result, we find M_HI/L_g ~ 6 Msun/Lsun, which is lower than previous work. At D=17 Mpc, AGC 226067 has an HI mass of 1.5 x 10^7 Msun and L_g = 2.4 x 10^6 Lsun, AGC 229490 (the HI-only component) has M_HI = 3.6 x 10^6 Msun, and AGC 229491 (the second optical component) has L_g = 3.6 x 10^5 Lsun. The nature of this system of three sources is uncertain: AGC 226067 and AGC 229490 may be connected by an HI bridge, and AGC 229490 and AGC 229491 are separated by only 0.5'. The current data do not resolve the HI in AGC 229490 and its origin is unclear. We discuss possible scenarios for this system of objects: an interacting system of dwarf galaxies, accretion of material onto AGC 226067, or stripping of material from AGC 226067.Comment: Accepted for publication in A&A. 6 pages, 4 figure

FDG-PET/CT in intensive care patients with bloodstream infection

BACKGROUND: 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single examination in patients with bloodstream infection (BSI) of unknown origin. However, literature on the use of this technique in intensive care patients is scarce. The purpose of this study was to evaluate the diagnostic yield of FDG-PET/CT in intensive care patients with BSI. METHODS: In this retrospective cohort study, all intensive care patients from our Dutch university medical center who had culture-proven BSI between 2010 and 2020 and underwent FDG-PET/CT to find the focus of infection were included. Diagnostic performance was calculated and logistic regression analysis was performed to evaluate the association between FDG-PET/CT outcome and C-reactive protein level (CRP), leukocyte count, duration of antibiotic treatment, duration of ICU stay, quality of FDG-PET/CT, and dependency on mechanical ventilation. In addition, the impact of FDG-PET/CT on clinical treatment was evaluated. RESULTS: 30 intensive care patients with BSI were included. In 21 patients, an infection focus was found on FDG-PET/CT which led to changes in clinical management in 14 patients. FDG-PET/CT achieved a sensitivity of 90.9% and specificity of 87.5% for identifying the focus of infection. Poor quality of the FDG-PET images significantly decreased the likelihood of finding an infection focus as compared to reasonable or good image quality (OR 0.16, P = 0.034). No other variables were significantly associated with FDG-PET/CT outcome. No adverse events during the FDG-PET/CT procedure were reported. CONCLUSION: FDG-PET/CT has a high diagnostic yield for detecting the infection focus in patients with BSI admitted to intensive care. Poor PET image quality was significantly associated with a decreased likelihood of finding the infection focus in patients with BSI. This could be improved by adequate dietary preparation and cessation of intravenous glucose and glucose-regulating drugs. Recent advances in PET/CT technology enable higher image quality with shorter imaging time and may contribute to routinely performing FDG-PET/CT in intensive care patients with BSI of unknown origin

The dwarf galaxy population as revealed by ALFALFA

The combination of sensitivity and large sky coverage of the ALFALFA HI survey has enabled the detection of difficult to observe low mass galaxies in large numbers, including dwarf galaxies overlooked in optical surveys. Three different, but connected, studies of dwarf galaxies from the ALFALFA survey are of particular interest: SHIELD (Survey of HI in Extremely Low-mass Dwarfs), candidate gas-rich ultra- faint dwarf galaxies, and the (Almost) Dark population. SHIELD is a systematic multiwavelength study of all dwarf galaxies from ALFALFA with MHI < 107.2 M☉ and clear optical counterparts. Candidate gas-rich ultra-faint dwarf galaxies extend the dwarf galaxy population to even lower masses. These galaxies are identified as isolated HI clouds with no discernible optical counterpart but subsequent observations reveal that some are extremely faint, gas- dominated galaxies. Leo P, discovered first as an HI detection, and then found to be an actively star-forming galaxy, bridges the gap between these candidate galaxies and the SHIELD sample. The (Almost) Dark sample consists of galaxies whose optical counterparts are overlooked in current optical surveys but which are clear detections in ALFALFA. This sample includes field gas-rich ultra-diffuse galaxies. Coma P, with a peak surface brightness of only ~26.4 mag arcsec-2 in g', demonstrates the sort of extreme low surface brightness galaxy that can be discovered in an HI survey

Gas Accretion and Star Formation Rates

Cosmological numerical simulations of galaxy evolution show that accretion of metal-poor gas from the cosmic web drives the star formation in galaxy disks. Unfortunately, the observational support for this theoretical prediction is still indirect, and modeling and analysis are required to identify hints as actual signs of star-formation feeding from metal-poor gas accretion. Thus, a meticulous interpretation of the observations is crucial, and this observational review begins with a simple theoretical description of the physical process and the key ingredients it involves, including the properties of the accreted gas and of the star-formation that it induces. A number of observations pointing out the connection between metal-poor gas accretion and star-formation are analyzed, specifically, the short gas consumption time-scale compared to the age of the stellar populations, the fundamental metallicity relationship, the relationship between disk morphology and gas metallicity, the existence of metallicity drops in starbursts of star-forming galaxies, the so-called G dwarf problem, the existence of a minimum metallicity for the star-forming gas in the local universe, the origin of the alpha-enhanced gas forming stars in the local universe, the metallicity of the quiescent BCDs, and the direct measurements of gas accretion onto galaxies. A final section discusses intrinsic difficulties to obtain direct observational evidence, and points out alternative observational pathways to further consolidate the current ideas.Comment: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by Springe

Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

Polymorphonuclear cells (neutrophils) play an important role in the systemic inflammatory response syndrome and the development of sepsis. These cells are essential for the defense against microorganisms, but may also cause tissue damage. Therefore, neutrophil numbers and activity are considered to be tightly regulated. Previous studies have investigated gene transcription during experimental endotoxemia in whole blood and peripheral blood mononuclear cells. However, the gene transcription response of the circulating pool of neutrophils to systemic inflammatory stimulation in vivo is currently unclear. We examined neutrophil gene transcription kinetics in healthy human subjects (n = 4) administered a single dose of endotoxin (LPS, 2 ng/kg iv). In addition, freshly isolated neutrophils were stimulated ex vivo with LPS, TNFα, G-CSF and GM-CSF to identify stimulus-specific gene transcription responses. Whole transcriptome microarray analysis of circulating neutrophils at 2, 4 and 6 hours after LPS infusion revealed activation of inflammatory networks which are involved in signaling of TNFα and IL-1α and IL-1β. The transcriptome profile of inflammatory activated neutrophils in vivo reflects extended survival and regulation of inflammatory responses. These changes in neutrophil transcriptome suggest a combination of early activation of circulating neutrophils by TNFα and G-CSF and a mobilization of young neutrophils from the bone marrow

ALFALFA Harvest:HI Imaging of Candidate Local Group Dwarf Galaxies

The ALFALFA blind extragalactic survey has populated the faint end of the neutral hydrogen (HI) mass function with statistical confidence for the first time. Of particular interest is a subset of the ALFALFA detections, termed "ultra-compact high-velocity clouds" (UCHVCs). These systems, if located within ~1 Mpc, would populate the lowest-mass end of the HI mass function. Subsequent optical imaging has revealed that some of these UCHVCs harbor associated (though sparse) stellar populations, revealing that they may be some of the most extreme galaxies known in the Local Volume, with optical properties akin to ultra-faint dwarf galaxies but with significant neutral gas reservoirs. In this campaign, we investigate the neutral hydrogen properties of six UCHVC candidate galaxies using deep VLA HI spectral line imaging. A companion poster (Bralts-Kelly et al.) presents 3D kinematic modeling of selected sources. Here, we show the imaging products and discuss the morphological and kinematic properties of the six chosen sources: AGC 198606, AGC 215417, AGC219656, AGC 249525, AGC 258237, and AGC 268069