Lookback time bounds from energy conditions

In general relativity, the energy conditions are invoked to restrict general energy-momentum tensors on physical grounds. We show that in the standard Friedmann-Lemaitre-Robertson-Walker (FLRW) approach to cosmological modeling, where the energy and matter components of the cosmic fluid are unknown, the energy conditions provide model-independent bounds on the behavior of the lookback time of cosmic sources as a function of the redshift for any value of the spatial curvature. We also confront such bounds with a lookback time sample which is built from the age estimates of 32 galaxies lying in the interval $0.11 \lesssim z \lesssim 1.84$ and by assuming the total expanding age of the Universe to be $13.7 \pm 0.2$ Gyr, as obtained from current cosmic microwave background experiments. In agreement with previous results, we show that all energy conditions seem to have been violated at some point of the recent past of cosmic evolution.Comment: 7 pages, 3 figures. v2: Minor changes, published in Phys.Rev.D in the present for

Energy Conditions and Cosmic Acceleration

In general relativity, the energy conditions are invoked to restrict general energy-momentum tensors $T_{\mu\nu}$ in different frameworks, and to derive general results that hold in a variety of general contexts on physical grounds. We show that in the standard Friedmann-Lemaitre-Robertson-Walker (FLRW) approach, where the equation of state of the cosmological fluid is unknown, the energy conditions provide model-independent bounds on the behavior of the distance modulus of cosmic sources as a function of the redshift for any spatial curvature. We use the most recent type Ia supernovae (SNe Ia) observations, which include the new Hubble Space Telescope SNe Ia events, to carry out a model-independent analysis of the energy conditions violation in the context of the standard cosmology. We show that both the null (NEC), weak (WEC) and dominant (DEC) conditions, which are associated with the existence of the so-called phantom fields, seem to have been violated only recently ($z \lesssim 0.2$), whereas the condition for attractive gravity, i.e., the strong energy condition (SEC) was firstly violated billions of years ago, at $z \gtrsim 1$.Comment: 6 pages, 3 figures. v2: References added, misprints corrected, published in Phys.Rev.D in the present for

HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

© 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease

Systematics of Xanthorrhoeaceae Sensu Lato, with an Emphasis on Bulbine

We provide here results of a combined analysis of plastid genes rbcL, matK, and ndhF for Xanthorrhoeaceae s.l., the Asphodelaceae/Xanthorrhoeaceae/Hemerocallidaceae clade, which are well supported by the DNA data. Xanthorrhoea (often treated as the sole member of Xanthorrhoeaceae) is sister to the hemerocallid clade (former Hemerocallidaceae); and the asphodelid clade (formerly Asphodelaceae) is sister to them both. For additional species of Bulbine and Jodrellia (both Asphodeloideae), we also collected rps16 intron and ITS nuclear ribosomal DNA sequences to better assess their relationships. Bulbine, with Jodrellia, embedded are sister to the collective genera of subfamily Alooideae in which all species are characterized by strongly bimodal and nearly identical karyotypes, whereas that of Bulbine is much more variable. Cytological studies have previously shown Bulbine to possess a range of karyotypes from graduated to clearly bimodal (although never exactly like the aloid genera) and point toward a lower level of bimodality in the Australian members, all of which are autotetraploid, than in the African members, all of which are diploid. Therefore, there have been two events of particular interest within Bulbine, a change in ploidy and a long-range dispersal event

Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest

Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain unexplored. The scarcity of rigorous scientific data on the surviving Mascarene endemic taxa renders bioprospecting of this untapped resource of utmost importance. Thus, in view of valorizing the native resource, this study has as its objective to investigate the bioactivities of endemic leaf extracts. Herein, seven Mascarene endemic plants leaves were extracted and evaluated for their in vitro antioxidant properties and antiproliferative effects on a panel of cancer cell lines, using methyl thiazolyl diphenyl-tetrazolium bromide (MTT) and clonogenic cell survival assays. Flow cytometry and comet assay were used to investigate the cell cycle and DNA damaging effects, respectively. Bioassay guided-fractionation coupled with liquid chromatography mass spectrometry (MS), gas chromatography-MS, and nuclear magnetic resonance spectroscopic analysis were used to identify the bioactive compounds. Among the seven plants tested, Terminaliabentzoë was comparatively the most potent antioxidant extract, with significantly (p < 0.05) higher cytotoxic activities. T. bentzoë extract further selectively suppressed the growth of human hepatocellular carcinoma cells and significantly halted the cell cycle progression in the G0/G1 phase, decreased the cells’ replicative potential and induced significant DNA damage. In total, 10 phenolic compounds, including punicalagin and ellagic acid, were identified and likely contributed to the extract’s potent antioxidant and cytotoxic activities. These results established a promising basis for further in-depth investigations into the potential use of T. bentzoë as a supportive therapy in cancer management

How the War in Ukraine Affects Food Security

The war in Ukraine has caused severe disruption to national and worldwide food supplies. Ukraine is a major exporter of wheat, maize, and oilseeds, staples that are now suffering a war-triggered supply risk. This paper describes the background of the problem and illustrates current trends by outlining some of the measures that may be deployed to mitigate the conflict’s impacts on achieving SDG 2 (Zero hunger), especially focusing on ending hunger, achieving food security, improving nutrition, and promoting sustainable agriculture. In order to understand the main research strands in the literature that are related to food security in the context of wars, the authors adopted a bibliometric literature review based on the co-occurrence of terms technique, conducted with 631 peer-reviewed documents extracted from the Scopus database. To complement the bibliometric assessment, ten case studies were selected to narrow down the food insecurity aspects caused by the war in Ukraine. The co-occurrence analysis indicated four different thematic clusters. In the next stage, an assessment of the current situation on how war affects food security was carried out for each one of the clusters, and the reasons and possible solutions to food security were identified. Policy recommendations and theoretical implications for food security in the conflict context in Ukraine were also addressed