Odd Frequency Pairing in the Kondo Lattice

We discuss the possibility that heavy fermion superconductors involve odd-frequency pairing of the kind first considered by Berezinskii. Using a toy model for odd frequency triplet pairing in the Kondo lattice we are able to examine key properties of this new type of paired state. To make progress treating the strong $n_f=1$ constraint in the Kondo lattice model we use the technical trick of a Majorana representation of the local moments, which permits variational treatments of the model without a Gutzwiller approximation. The simplest mean field theory involves the development of bound states between the local moments and conduction electrons, characterized by a spinor order parameter. We show that this state is a stable realization of odd frequency triplet superconductivity with surfaces of gapless excitations whose spin and charge coherence factors vanish linearly in the quasiparticle energy. A $T^3$ NMR relaxation rate coexists with a linear specific heat. We discuss possible extensions of our toy model to describe heavy fermion superconductivity.Comment: 67 page

Non-Coding Changes Cause Sex-Specific Wing Size Differences between Closely Related Species of Nasonia

The genetic basis of morphological differences among species is still poorly understood. We investigated the genetic basis of sex-specific differences in wing size between two closely related species of Nasonia by positional cloning a major male-specific locus, wing-size1 (ws1). Male wing size increases by 45% through cell size and cell number changes when the ws1 allele from N. giraulti is backcrossed into a N. vitripennis genetic background. A positional cloning approach was used to fine-scale map the ws1 locus to a 13.5 kilobase region. This region falls between prospero (a transcription factor involved in neurogenesis) and the master sex-determining gene doublesex. It contains the 5′-UTR and cis-regulatory domain of doublesex, and no coding sequence. Wing size reduction correlates with an increase in doublesex expression level that is specific to developing male wings. Our results indicate that non-coding changes are responsible for recent divergence in sex-specific morphology between two closely related species. We have not yet resolved whether wing size evolution at the ws1 locus is caused by regulatory alterations of dsx or prospero, or by another mechanism. This study demonstrates the feasibility of efficient positional cloning of quantitative trait loci (QTL) involved in a broad array of phenotypic differences among Nasonia species

IEA wind recommended practices for the implementation of wind power forecasting solutions part 2 and 3 : designing and executing forecasting benchmarks and evaluation of forecast solutions

In this paper, we summarize the second and third part of a series of three IEA Recommended Practice documents for the power industry that deal with how to setup and run a trial or benchmark as well as verifying the goodness of forecast solutions. The Recommended Practice is intended to serve as a set of standards that provide guidance for private industry, academics and government for the process of obtaining an optimal forecast solution for specific applications as well as the ongoing evaluation of the performance of the solution to increase the probability that it continues to be an optimal solution as forecast technology evolves. The work is part of the IEA Wind Task 36 on Wind Power Forecasting

Expert Elicitation on Wind Farm Control

Wind farm control is an active and growing field of research in which the control actions of individual turbines in a farm are coordinated, accounting for inter-turbine aerodynamic interaction, to improve the overall performance of the wind farm and to reduce costs. The primary objectives of wind farm control include increasing power production, reducing turbine loads, and providing electricity grid support services. Additional objectives include improving reliability or reducing external impacts to the environment and communities. In 2019, a European research project (FarmConners) was started with the main goal of providing an overview of the state-of-the-art in wind farm control, identifying consensus of research findings, data sets, and best practices, providing a summary of the main research challenges, and establishing a roadmap on how to address these challenges. Complementary to the FarmConners project, an IEA Wind Topical Expert Meeting (TEM) and two rounds of surveys among experts were performed. From these events we can clearly identify an interest in more public validation campaigns. Additionally, a deeper understanding of the mechanical loads and the uncertainties concerning the effectiveness of wind farm control are considered two major research gaps

Tracking Interacting Objects Optimally Using Integer Programming

In this paper, we show that tracking different kinds of interacting objects can be formulated as a network-flow Mixed Integer Program. This is made possible by tracking all objects simultaneously and expressing the fact that one object can appear or disappear at locations where another is in terms of linear flow constraints. We demonstrate the power of our approach on scenes involving cars and pedestrians, bags being carried and dropped by people, and balls being passed from one player to the next in a basketball game. In particular, we show that by estimating jointly and globally the trajectories of different types of objects, the presence of the ones which were not initially detected based solely on image evidence can be inferred from the detections of the others

What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England.

OBJECTIVES: The aim of this study was to identify the most important determinants of accident and emergency (A&E) attendance in disadvantaged areas. DESIGN, SETTING AND PARTICIPANTS: A total of 3510 residents from 20 disadvantaged neighbourhoods in the North West Coast area in England completed a comprehensive public health survey. MAIN OUTCOME MEASURES: Participants were asked to complete general background information, as well as information about their physical health, mental health, lifestyle, social issues, housing and environment, work and finances, and healthcare service usage. Only one resident per household could take part in the survey. Poisson regression analysis was employed to assess the predictors of A&E attendance frequency in the previous 12 months. RESULTS: 31.6% of the sample reported having attended A&E in the previous 12 months, ranging from 1 to 95 visits. Controlling for demographic and health factors, not being in employment and living in poor quality housing increased the likelihood of attending an A&E service. Service access was also found to be predictive of A&E attendance insofar as there were an additional 18 fewer A&E attendances per 100 population for each kilometre closer a person lived to a general practitioner (GP) practice, and 3 fewer attendances per 100 population for each kilometre further a person lived from an A&E department. CONCLUSIONS: This is one of the first surveys to explore a comprehensive set of socio-economic factors as well as proximity to both GP and A&E services as predictors of A&E attendance in disadvantaged areas. Findings from this study suggest the need to address both socioeconomic issues, such as employment and housing quality, as well as structural issues, such as public transport and access to primary care, to reduce the current burden on A&E departments

Stanowisko polskich ekspertów dotyczące zastosowania leku brentuksymab vedotin w leczeniu chorych na pierwotne chłoniaki skóry CD30+

The group of primary cutaneous T-cell lymphomas (CTCLs) expressing CD30 + is consisted of primary cutaneous anaplastic T-cell lymphoma (pcACTL), lymphomatoid papulosis (LyP), some cases of mycosis fungoides (MF) and Sezary syndrome (SS). It is well known that patient cannot be cured completely by available therapeutic methods. In addition, the effectiveness of available therapies is especially limited in advanced stages of the disease. Based on the results of the most recent trials, the experts recommend that brentuximab vedotin (BV) should be reimbursed in Poland for the treatment of adult patients with CTCL expressing CD30 who have had at least one prior systemic treatment. In case of MF BV should be preferred to bexarotene or MTX therapy due to the higher efficacy in stage IIB or higher. BV treatment should be also considered as an alternative to bexarotene (after ineffectiveness of local treatment, phototherapy and IFN/MTX therapy) in early stages of MF (IB-IIA).Do pierwotnych chłoniaków skóry T-komórkowych (CTCL) z ekspresją CD30+ należą pierwotny skórny chłoniak anaplastyczny z dużych komórek (pcALCL), lymphomatoid papulosis (LyP), a także ziarniniak grzybiasty (MF) i zespół Sézary’ego (SS), spośród których u części można stwierdzić ekspresję CD30+. Istniejące metody terapii nie pozwalają na wyleczenie pacjenta cho­rującego na wymienione wyżej odmiany chłoniaków. Ponadto skuteczność dostępnych metod jest szczególnie ograniczona w zaawansowanych stadiach choroby. Na podstawie wyników najnowszych badań eksperci rekomendują, aby brentuksymab vedotin (BV) był dostępny w Polsce do leczenia do­rosłych pacjentów z CTCL z ekspresją CD30, u których uprzednio stosowano co najmniej jedno le­czenie systemowe. W stadium MF IIB i wyższym leczenie BV powinno być preferowane w stosunku do terapii beksarotenem lub metotreksatem (MTX) ze względu na wyższą skuteczność nowego leku. We wczesnych stadiach MF (IB–IIA) należy rozważyć leczenie BV alternatywnie do stosowania bek­sarotenu (po nieskuteczności leczenia miejscowego, fototerapii i terapii interferonem i/lub MTX). Skuteczność leczenia BV wykazano u chorych z pcALCL zarówno we wczesnej fazie z obecnością zmian ograniczonych do skóry, jak i w postaci zaawansowanej z pozaskórną lokalizacją zmian