6,726 research outputs found

    Now the wars are over: The past, present and future of Scottish battlefields

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    Battlefield archaeology has provided a new way of appreciating historic battlefields. This paper provides a summary of the long history of warfare and conflict in Scotland which has given rise to a large number of battlefield sites. Recent moves to highlight the archaeological importance of these sites, in the form of Historic Scotland’s Battlefields Inventory are discussed, along with some of the problems associated with the preservation and management of these important cultural sites

    Self-organization of actin filament orientation in the dendritic-nucleation/array-treadmilling model

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    Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of National Academy of Sciences of the USA for personal use, not for redistribution. The definitive version was published in Proceedings of the National Academy of Sciences 104 (2007): 7086-7091, doi:10.1073/pnas.0701943104.The dendritic-nucleation/array-treadmilling model provides a conceptual framework for the generation of the actin network driving motile cells. We have incorporated it into a 2-D, stochastic computer model to study lamellipodia via the self-organization of filament orientation patterns. Essential dendritic-nucleation sub-models were incorporated, including discretized actin monomer diffusion, Monte-Carlo filament kinetics, and flexible filament and plasma membrane mechanics. Model parameters were estimated from the literature and simulation, providing values for the extent of the leading edge branching/capping-protective zone (5.4 nm) and the auto-catalytic branch rate (0.43 /s). For a given set of parameters the system evolved to a steady state filament count and velocity, at which total branching and capping rates were equal only for specific orientations; net capping eliminated others. The standard parameter set evoked a sharp preference for the ±35 deg. filaments seen in lamellipodial electron micrographs, requiring ~ 12 generations of successive branching to adapt to a 15 deg. change in protrusion direction. This pattern was robust with respect to membrane surface and bending energies and to actin concentrations, but required protection from capping at the leading edge and branching angles greater than 60 deg. A +70/0/-70 deg. pattern was formed with flexible filaments ~ 100 nm or longer and with velocities less than ~ 20% of free polymerization rates

    End states, ladder compounds, and domain wall fermions

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    A magnetic field applied to a cross linked ladder compound can generate isolated electronic states bound to the ends of the chain. After exploring the interference phenomena responsible, I discuss a connection to the domain wall approach to chiral fermions in lattice gauge theory. The robust nature of the states under small variations of the bond strengths is tied to chiral symmetry and the multiplicative renormalization of fermion masses.Comment: 10 pages, 4 figures; final version for Phys. Rev. Let

    Static stress drop associated with brittle slip events on exhumed faults

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    We estimate the static stress drop on small exhumed strike-slip faults in the Lake Edison granodiorite of the central Sierra Nevada (California). The sub-vertical strike-slip faults were exhumed from 4-15 km depth, and were chosen because they are exposed in outcrop along their entire tip-to-tip lengths of 8-12 m. Slip nucleated on joints and accumulated by ductile shearing (forming quartz mylonites from early quartz vein filling in joints) and successive brittle faulting (forming epidote-bearing cataclasites). The occurrence of thin, < 1 mm wide, pseudotachylytes along some small faults throughout the study area suggests that some portion of the brittle slip was seismic. We suggest that the contribution of seismic slip to the total slip along the studied cataclasite-bearing small faults may be estimated by the length of epidote-filled, rhombohedral dilatational jogs (rhombochasms) distributed semi-periodically along the length of the faults. The interpretation that slip recorded by rhombochasms occurred in single events is based on evidence that: 1) epidote crystals are randomly oriented and undeformed within the rhombochasm; and 2) cataclasite structure in principal slip zones does not include clasts of previous cataclasite. We thereby constrain both the rupture length and slip. Based on these measurements, we calculate stress drops ranging over 90-250 MPa, i.e., one to two orders of magnitude larger than typical seismological estimates for earthquakes, but similar in magnitude to recent observations of small (< M2) earthquakes from the San Andreas Fault Observatory at Depth (SAFOD). These inferred seismic ruptures occurred along small, deep-seated faults, and, given the calculated stress drops and observations that brittle faults exploited joints sealed by quartz-bearing mylonite, we conclude that these were “strong” faults

    Analytical results for string propagation near a Kaluza-Klein black hole

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    This brief report presents analytical solutions to the equations of motion of a null string. The background spacetime is a magnetically charged Kaluza-Klein black hole. The string coordinates are expanded with the world-sheet velocity of light as an expansion parameter. It is shown that the zeroth order solutions can be expressed in terms of elementary functions in an appropriate large distance approximation. In addition, a class of exact solutions corresponding to the Pollard-Gross-Perry-Sorkin monopole case is also obtained.Comment: Revtex, 9 pages including two postscript figures, More detailed discussion and new references adde

    Defining Metastatic Cell Latency

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    Pair Creation of Dilaton Black Holes

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    We consider dilaton gravity theories in four spacetime dimensions parametrised by a constant aa, which controls the dilaton coupling, and construct new exact solutions. We first generalise the C-metric of Einstein-Maxwell theory (a=0a=0) to solutions corresponding to oppositely charged dilaton black holes undergoing uniform acceleration for general aa. We next develop a solution generating technique which allows us to ``embed" the dilaton C-metrics in magnetic dilaton Melvin backgrounds, thus generalising the Ernst metric of Einstein-Maxwell theory. By adjusting the parameters appropriately, it is possible to eliminate the nodal singularities of the dilaton C-metrics. For a<1a<1 (but not for a≄1a\ge 1), it is possible to further restrict the parameters so that the dilaton Ernst solutions have a smooth euclidean section with topology S2×S2−{pt}S^2\times S^2-{\rm\{pt\}}, corresponding to instantons describing the pair production of dilaton black holes in a magnetic field. A different restriction on the parameters leads to smooth instantons for all values of aa with topology S2×R2S^2\times \R^2.Comment: 22 pages, EFI-93-51, FERMILAB-Pub-93/272-A, UMHEP-393. (Asymptotics of Ernst solutions clarified, typos repaired

    Matrix-free calcium in isolated chromaffin vesicles

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    Isolated secretory vesicles from bovine adrenal medulla contain 80 nmol of Ca2+ and 25 nmol of Mg2+ per milligram of protein. As determined with a Ca2+-selective electrode, a further accumulation of about 160 nmol of Ca2+/mg of protein can be attained upon addition of the Ca2+ ionophore A23187. During this process protons are released from the vesicles, in exchange for Ca2+ ions, as indicated by the decrease of the pH in the incubation medium or the release of 9-aminoacridine previously taken up by the vesicles. Intravesicular Mg2+ is not released from the vesicles by A23 187, as determined by atomic emission spectroscopy. In the presence of N H Q , which causes the collapse of the secretory vesicle transmembrane proton gradient (ApH), Ca2+ uptake decreases. Under these conditions A23 187-mediated influx of Ca2+ and efflux of H+ cease at Ca2+ concentrations of about 4 pM. Below this concentration Ca2+ is even released from the vesicles. At the Ca2+ concentration at which no net flux of ions occurs the intravesicular matrix free Ca2+ equals the extravesicular free Ca2+. In the absence of NH4C1 we determined an intravesicular pH of 6.2. Under these conditions the Ca2+ influx ceases around 0.15 pM. From this value and the known pH across the vesicular membrane an intravesicular matrix free Ca2+ concentration of about 24 pM was calculated. This is within the same order of magnitude as the concentration of free Ca2+ in the vesicles determined in the presence of NH4C1. Calculation of the total Ca2+ present in the secretory vesicles gives an apparent intravesicular Ca2+ concentration of 40 mM, which is a factor of lo4 higher than the free intravesicular concentration of Ca2+. It can be concluded, therefore, that the concentration gradient of free Ca2+ across the secretory vesicle membrane in the intact chromaffin cells is probably small, which implies that less energy is required to accumulate and maintain Ca2+ within the vesicles than was previously anticipated
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