The neighbourhood physical environment and active travel in older adults : a systematic review and meta-analysis

BACKGROUND: Perceived and objectively-assessed aspects of the neighbourhood physical environment have been postulated to be key contributors to regular engagement in active travel (AT) in older adults. We systematically reviewed the literature on neighbourhood physical environmental correlates of AT in older adults and applied a novel meta-analytic approach to statistically quantify the strength of evidence for environment-AT associations. METHODS: Forty two quantitative studies that estimated associations of aspects of the neighbourhood built environment with AT in older adults (aged ≥ 65 years) and met selection criteria were reviewed and meta-analysed. Findings were analysed according to five AT outcomes (total walking for transport, within-neighbourhood walking for transport, combined walking and cycling for transport, cycling for transport, and all AT outcomes combined) and seven categories of the neighbourhood physical environment (residential density/urbanisation, walkability, street connectivity, access to/availability of services/destinations, pedestrian and cycling infrastructure, aesthetics and cleanliness/order, and safety and traffic). RESULTS: Most studies examined correlates of total walking for transport. A sufficient amount of evidence of positive associations with total walking for transport was found for residential density/urbanisation, walkability, street connectivity, overall access to destinations/services, land use mix, pedestrian-friendly features and access to several types of destinations. Littering/vandalism/decay was negatively related to total walking for transport. Limited evidence was available on correlates of cycling and combined walking and cycling for transport, while sufficient evidence emerged for a positive association of within-neighbourhood walking with pedestrian-friendly features and availability of benches/sitting facilities. Correlates of all AT combined mirrored those of walking for transport. Positive associations were also observed with food outlets, business/institutional/industrial destinations, availability of street lights, easy access to building entrance and human and motorised traffic volume. Several but inconsistent individual- and environmental-level moderators of associations were identified. CONCLUSIONS: Results support strong links between the neighbourhood physical environment and older adults’ AT. Future research should focus on the identification of types and mixes of destinations that support AT in older adults and how these interact with individual characteristics and other environmental factors. Future research should also aim to clarify dose-response relationships through multi-country investigations and data-pooling from diverse geographical regions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12966-017-0471-5) contains supplementary material, which is available to authorized users

Entropy/IP: Uncovering Structure in IPv6 Addresses

In this paper, we introduce Entropy/IP: a system that discovers Internet address structure based on analyses of a subset of IPv6 addresses known to be active, i.e., training data, gleaned by readily available passive and active means. The system is completely automated and employs a combination of information-theoretic and machine learning techniques to probabilistically model IPv6 addresses. We present results showing that our system is effective in exposing structural characteristics of portions of the IPv6 Internet address space populated by active client, service, and router addresses. In addition to visualizing the address structure for exploration, the system uses its models to generate candidate target addresses for scanning. For each of 15 evaluated datasets, we train on 1K addresses and generate 1M candidates for scanning. We achieve some success in 14 datasets, finding up to 40% of the generated addresses to be active. In 11 of these datasets, we find active network identifiers (e.g., /64 prefixes or `subnets') not seen in training. Thus, we provide the first evidence that it is practical to discover subnets and hosts by scanning probabilistically selected areas of the IPv6 address space not known to contain active hosts a priori.Comment: Paper presented at the ACM IMC 2016 in Santa Monica, USA (https://dl.acm.org/citation.cfm?id=2987445). Live Demo site available at http://www.entropy-ip.com

STRATEGI PENCEGAHAN NARKOLEMA DAN PERNIKAHAN DINI DI KALANGAN REMAJA MELALUI INISIASI POSYANDU REMAJA

Data Panitera Pengadilan Agama Wonosari Gunung Kidul Tahun 2020 menunjukkan angka pernikahan dini naik 100% dibandingkan tahun 2019 yang mencapai 108 perkara. Dusun Ngunut Tengah salah satu Dusun di Playen, Gunung kidul 26% pernikahan usia remaja. Hasil wawancara remaja di Dusun Ngunut Tengah sebanyak 83% pernah melihat pornografi. Narkolema merupakan pornografi yang dapat di akses lewat mata. Untuk mencegah bahaya narkolema pada remaja diinisiasi pembentukan Posyandu remaja. Pengabdian masyarakat bertujuan untuk menurunkan jumlah pernikahan remaja dengan menginisiasi Posyandu Remaja di Dusun Ngunut Tengah RT 08, RW:02 Kapanewon Playen. Metode pelaksanaan kegiatan meliputi penyuluhan dan pelatihan kader posyandu remaja serta pendampingan posyandu remaja. Hasil pengabdian masyarakat berupa inisiasi pembentukan Posyandu Remaja, tercetaknya Buku Saku Bahaya Narkolema dan pencegahannya pada remaja, yang telah memperoleh sertifikat Hak Cipta. Hasil pelatihan kader remaja menunjukkan efektifitas pelatihan kader posyandu remaja dilihat dari peningkatan nilai pretest dan posttest (rata- rata beda mean 40,02). Hasil pendampingan posyandu remaja menunjukkan sebesar 33,3% remaja memiliki IMT ideal, 87,5% remaja tidak mengalami Kurang Energi Kronis (KEK), 75 % memiliki ukuran lingkar perut normal dan 91,6% remaja menunjukkan tekanan darah dalam batas normal

HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

© 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease