The Great Debate Between John W. Ring and J. W. Chism

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Turmeric Extract Rescues Ethanol‐Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD)

Prenatal ethanol exposure causes the most frequent preventable birth disorder, fetal alcohol spectrum disorder (FASD). The effect of turmeric extracts in rescuing an ethanol‐induced developmental defect using zebrafish as a model was determined. Ethanol‐induced oxidative stress is one of the major mechanisms underlying FASD. We hypothesize that antioxidant inducing properties of turmeric may alleviate ethanol‐induced defects. Curcuminoid content of the turmeric powder extract (5 mg/mL turmeric in ethanol) was determined by UPLC and found to contain Curcumin (124.1 ± 0.2 μg/mL), Desmethoxycurcumin (43.4 ± 0.1 μg/mL), and Bisdemethoxycurcumin (36.6 ± 0.1 μg/mL). Zebrafish embryos were treated with 100 mM (0.6% v/v) ethanol during gastrulation through organogenesis (2 to 48 h postfertilization (hpf)) and supplemented with turmeric extract to obtain total curcuminoid concentrations of 0, 1.16, 1.72, or 2.32 μM. Turmeric supplementation showed significant rescue of the body length at 72 hpf compared to ethanol‐treated embryos. The mechanism underlying the rescue remains to be determined

Changes in Floquet state structure at avoided crossings: delocalization and harmonic generation

Avoided crossings are common in the quasienergy spectra of strongly driven nonlinear quantum wells. In this paper we examine the sinusoidally driven particle in a square potential well to show that avoided crossings can alter the structure of Floquet states in this system. Two types of avoided crossings are identified: on type leads only to temporary changes (as a function of driving field strength) in Floquet state structure while the second type can lead to permanent delocalization of the Floquet states. Radiation spectra from these latter states show significant increase in high harmonic generation as the system passes through the avoided crossing.Comment: 8 pages with 10 figures submitted to Physical Review

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

The identification of molecular subtype heterogeneity in breast cancer has allowed a deeper understanding of breast cancer biology. We present evidence that there are two intrinsic subtypes of high-grade bladder cancer, basal-like and luminal, which reflect the hallmarks of breast biology. Moreover, we have developed an accurate gene set predictor of molecular subtype, the BASE47, that should allow the incorporation of subtype stratification into clinical trials. Further clinical, etiologic, and therapeutic response associations will be of interest in future investigations