491 research outputs found
Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons
Melanocortin 4 receptors (MC4Rs) in the central nervous system are key regulators of energy and glucose homeostasis. Notably, obese patients with MC4R mutations are hyperinsulinemic and resistant to obesity-induced hypertension. Although these effects are likely dependent upon the activity of the autonomic nervous system, the cellular effects of MC4Rs on parasympathetic and sympathetic neurons remain undefined. Here, we show that MC4R agonists inhibit parasympathetic preganglionic neurons in the brainstem. In contrast, MC4R agonists activate sympathetic preganglionic neurons in the spinal cord. Deletion of MC4Rs in cholinergic neurons resulted in elevated levels of insulin. Furthermore, re-expression of MC4Rs specifically in cholinergic neurons (including sympathetic preganglionic neurons) restores obesity-associated hypertension in MC4R null mice. These findings provide a cellular correlate of the autonomic side effects associated with MC4R agonists and demonstrate a role for MC4Rs expressed in cholinergic neurons in the regulation of insulin levels and in the development of obesity-induced hypertension
Compositionality in animals and humans
Funding: University of Zurich Research Priority Program (grant number URPP, Evolution in Action; URPP U-702-06). Received by SWT and BB. Swiss National Science Foundation (grant number SWT: PP003_163860; SE: PP003_163860; P1ZHP3_151648; KZ grant: 31003A_166458). Received by SWT, SE and KZ. European Research Council under the European Union’s 7th Framework Programme (grant number FP7/2007-2013/ ERC grant agreement no (615988)). Received by SS.A key step in understanding the evolution of human language involves unravelling the origins of language’s syntactic structure. One approach seeks to reduce the core of syntax in humans to a single principle of recursive combination, merge, for which there is no evidence in other species. We argue for an alternative approach. We review evidence that beneath the staggering complexity of human syntax, there is an extensive layer of nonproductive, nonhierarchical syntax that can be fruitfully compared to animal call combinations. This is the essential groundwork that must be explored and integrated before we can elucidate, with sufficient precision, what exactly made it possible for human language to explode its syntactic capacity, transitioning from simple nonproductive combinations to the unrivalled complexity that we now have.Publisher PDFPeer reviewe
A Laser Frequency Comb System for Absolute Calibration of the VTT Echelle Spectrograph
A wavelength calibration system based on a laser frequency comb (LFC) was
developed in a co-operation between the Kiepenheuer-Institut f\"ur
Sonnenphysik, Freiburg, Germany and the Max-Planck-Institut f\"ur Quantenoptik,
Garching, Germany for permanent installation at the German Vacuum Tower
Telescope (VTT) on Tenerife, Canary Islands. The system was installed
successfully in October 2011. By simultaneously recording the spectra from the
Sun and the LFC, for each exposure a calibration curve can be derived from the
known frequencies of the comb modes that is suitable for absolute calibration
at the meters per second level. We briefly summarize some topics in solar
physics that benefit from absolute spectroscopy and point out the advantages of
LFC compared to traditional calibration techniques. We also sketch the basic
setup of the VTT calibration system and its integration with the existing
echelle spectrograph.Comment: 9 pages, 2 figures; Solar Physics 277 (2012
Jurassic shift from abiotic to biotic control on marine ecological success
Environmental change and biotic interactions both govern the evolution of the biosphere, but the relative importance of these drivers over geological time remains largely unknown. Previous work suggests that, unlike environmental parameters, diversity dynamics differ profoundly between the Palaeozoic and post-Palaeozoic eras. Here we use the fossil record to test the hypothesis that the influence of ocean chemistry and climate on the ecological success of marine calcifiers decreased throughout the Phanerozoic eon. Marine calcifiers build skeletons of calcite or aragonite, and the precipitation of these calcium carbonate polymorphs is governed by the magnesium-to-calcium ratio and temperature in abiotic systems. We developed an environmental forcing model based on secular changes of ocean chemistry and temperature and assessed how well the model predicts the proliferation of skeletal taxa with respect to calcium carbonate polymorphs. Abiotic forcing governs the ecological success of aragonitic calcifiers from the Ordovician to the Middle Jurassic, but not thereafter. This regime shift coincides with the proliferation of calcareous plankton in the mid-Mesozoic. The deposition of biomineralizing plankton on the ocean floor buffers CO2 excursions and stabilizes Earth’s biochemical cycle, and thus mitigates the evolutionary impact of environmental change on the marine biota
Magnetic fields of opposite polarity in sunspot penumbrae
Context. A significant part of the penumbral magnetic field returns below the
surface in the very deep photosphere. For lines in the visible, a large portion
of this return field can only be detected indirectly by studying its imprints
on strongly asymmetric and three-lobed Stokes V profiles. Infrared lines probe
a narrow layer in the very deep photosphere, providing the possibility of
directly measuring the orientation of magnetic fields close to the solar
surface.
Aims. We study the topology of the penumbral magnetic field in the lower
photosphere, focusing on regions where it returns below the surface.
Methods. We analyzed 71 spectropolarimetric datasets from Hinode and from the
GREGOR infrared spectrograph. We inferred the quality and polarimetric accuracy
of the infrared data after applying several reduction steps. Techniques of
spectral inversion and forward synthesis were used to test the detection
algorithm. We compared the morphology and the fractional penumbral area covered
by reversed-polarity and three-lobed Stokes V profiles for sunspots at disk
center. We determined the amount of reversed-polarity and three-lobed Stokes V
profiles in visible and infrared data of sunspots at various heliocentric
angles. From the results, we computed center-to-limb variation curves, which
were interpreted in the context of existing penumbral models.
Results. Observations in visible and near-infrared spectral lines yield a
significant difference in the penumbral area covered by magnetic fields of
opposite polarity. In the infrared, the number of reversed-polarity Stokes V
profiles is smaller by a factor of two than in the visible. For three-lobed
Stokes V profiles the numbers differ by up to an order of magnitude.Comment: 11 pages 10 figures plus appendix (2 pages 3 figures). Accepted as
part of the A&A special issue on the GREGOR solar telescop
Spectropolarimetric observations of an arch filament system with the GREGOR solar telescope
Arch filament systems occur in active sunspot groups, where a fibril
structure connects areas of opposite magnetic polarity, in contrast to active
region filaments that follow the polarity inversion line. We used the GREGOR
Infrared Spectrograph (GRIS) to obtain the full Stokes vector in the spectral
lines Si I 1082.7 nm, He I 1083.0 nm, and Ca I 1083.9 nm. We focus on the
near-infrared calcium line to investigate the photospheric magnetic field and
velocities, and use the line core intensities and velocities of the helium line
to study the chromospheric plasma. The individual fibrils of the arch filament
system connect the sunspot with patches of magnetic polarity opposite to that
of the spot. These patches do not necessarily coincide with pores, where the
magnetic field is strongest. Instead, areas are preferred not far from the
polarity inversion line. These areas exhibit photospheric downflows of moderate
velocity, but significantly higher downflows of up to 30 km/s in the
chromospheric helium line. Our findings can be explained with new emerging flux
where the matter flows downward along the fieldlines of rising flux tubes, in
agreement with earlier results.Comment: Proceedings 12th Potsdam Thinkshop to appear in Astronomische
Nachrichte
Photospheric Magnetic Fields of the Trailing Sunspots in Active Region NOAA 12396
The solar magnetic field is responsible for all aspects of solar activity.
Sunspots are the main manifestation of the ensuing solar activity. Combining
high-resolution and synoptic observations has the ambition to provide a
comprehensive description of the sunspot growth and decay processes. Active
region NOAA 12396 emerged on 2015 August 3 and was observed three days later
with the 1.5-meter GREGOR solar telescope on 2015 August 6. High-resolution
spectropolarimetric data from the GREGOR Infrared Spectrograph (GRIS) are
obtained in the photospheric Si I 1082.7 nm and Ca I 1083.9
nm lines, together with the chromospheric He I 1083.0 nm triplet.
These near-infrared spectropolarimetric observations were complemented by
synoptic line-of-sight magnetograms and continuum images of the Helioseismic
and Magnetic Imager (HMI) and EUV images of the Atmospheric Imaging Assembly
(AIA) on board the Solar Dynamics Observatory (SDO).Comment: 4 pages, 2 figures, to be published in "Solar Polarization Workshop
8", ASP Proceedings, Luca Belluzzi (eds.
Two-Dimensional Spectroscopy of Photospheric Shear Flows in a Small delta Spot
In recent high-resolution observations of complex active regions,
long-lasting and well-defined regions of strong flows were identified in major
flares and associated with bright kernels of visible, near-infrared, and X-ray
radiation. These flows, which occurred in the proximity of the magnetic neutral
line, significantly contributed to the generation of magnetic shear. Signatures
of these shear flows are strongly curved penumbral filaments, which are almost
tangential to sunspot umbrae rather than exhibiting the typical radial
filamentary structure. Solar active region NOAA 10756 was a moderately complex,
beta-delta sunspot group, which provided an opportunity to extend previous
studies of such shear flows to quieter settings. We conclude that shear flows
are a common phenomenon in complex active regions and delta spots. However,
they are not necessarily a prerequisite condition for flaring. Indeed, in the
present observations, the photospheric shear flows along the magnetic neutral
line are not related to any change of the local magnetic shear. We present
high-resolution observations of NOAA 10756 obtained with the 65-cm vacuum
reflector at Big Bear Solar Observatory (BBSO). Time series of
speckle-reconstructed white-light images and two-dimensional spectroscopic data
were combined to study the temporal evolution of the three-dimensional vector
flow field in the beta-delta sunspot group. An hour-long data set of consistent
high quality was obtained, which had a cadence of better than 30 seconds and
sub-arcsecond spatial resolution.Comment: 23 pages, 6 gray-scale figures, 4 color figures, 2 tables, submitted
to Solar Physic
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