9,067 research outputs found
Sustainable product development strategies: Business planning and performance implications
Copyright © 2012 by Institution of Mechanical Engineers. This is the author's accepted manuscript. The final published article is available from the link below.Manufacturing firms are under many financial and competitive pressures which focus attention on the performance of their manufacturing processes. In this paper the opportunities for improving the environmental impact of products within the constraints of existing manufacturing infrastructure are examined. Approaches which support sustainability in two aspects are proposed, firstly, the provision of products to the users in ways which extend the product life and secondly, manufacturing approaches which reduce resource usage. This paper outlines three different sustainable development strategies for different product types and describes the cost implications for manufacturers across the life-cycle. The performance measures affected by these strategies are examined drawing on product development case studies from a number of high technology sectors to highlight the different approaches taken. The results are intended to aid manufacturers during the earliest stages of business planning to consider alternative product development approaches which are more sustainable
Privacy in the Genomic Era
Genome sequencing technology has advanced at a rapid pace and it is now
possible to generate highly-detailed genotypes inexpensively. The collection
and analysis of such data has the potential to support various applications,
including personalized medical services. While the benefits of the genomics
revolution are trumpeted by the biomedical community, the increased
availability of such data has major implications for personal privacy; notably
because the genome has certain essential features, which include (but are not
limited to) (i) an association with traits and certain diseases, (ii)
identification capability (e.g., forensics), and (iii) revelation of family
relationships. Moreover, direct-to-consumer DNA testing increases the
likelihood that genome data will be made available in less regulated
environments, such as the Internet and for-profit companies. The problem of
genome data privacy thus resides at the crossroads of computer science,
medicine, and public policy. While the computer scientists have addressed data
privacy for various data types, there has been less attention dedicated to
genomic data. Thus, the goal of this paper is to provide a systematization of
knowledge for the computer science community. In doing so, we address some of
the (sometimes erroneous) beliefs of this field and we report on a survey we
conducted about genome data privacy with biomedical specialists. Then, after
characterizing the genome privacy problem, we review the state-of-the-art
regarding privacy attacks on genomic data and strategies for mitigating such
attacks, as well as contextualizing these attacks from the perspective of
medicine and public policy. This paper concludes with an enumeration of the
challenges for genome data privacy and presents a framework to systematize the
analysis of threats and the design of countermeasures as the field moves
forward
Micro-evaporators for kinetic exploration of phase diagrams
We use pervaporation-based microfluidic devices to concentrate species in
aqueous solutions with spatial and temporal control of the process. Using
experiments and modelling, we quantitatively describe the advection-diffusion
behavior of the concentration field of various solutions (electrolytes,
colloids, etc) and demonstrate the potential of these devices as universal
tools for the kinetic exploration of the phases and textures that form upon
concentration
Gamma-ray emission from dark matter wakes of recoiled black holes
A new scenario for the emission of high-energy gamma-rays from dark matter
annihilation around massive black holes is presented. A black hole can leave
its parent halo, by means of gravitational radiation recoil, in a merger event
or in the asymmetric collapse of its progenitor star. A recoiled black hole
which moves on an almost-radial orbit outside the virial radius of its central
halo, in the cold dark matter background, reaches its apapsis in a finite time.
Near or at the apapsis passage, a high-density wake extending over a large
radius of influence, forms around the black hole. It is shown that significant
gamma-ray emission can result from the enhancement of neutralino annihilation
in these wakes. At its apapsis passage, a black hole is shown to produce a
flash of high-energy gamma-rays whose duration is determined by the mass of the
black hole and the redshift at which it is ejected. The ensemble of such black
holes in the Hubble volume is shown to produce a diffuse high-energy gamma-ray
background whose magnitude is compared to the diffuse emission from dark matter
haloes alone.Comment: version to appear in Astrophysical Journal letters (labels on Fig. 3
corrected
Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans
Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an “imaging needle” that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, \u3e500 μm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions
Anomalous Dimension and Spatial Correlations in a Point-Island Model
We examine the island size distribution function and spatial correlation
function of a model for island growth in the submonolayer regime in both 1 and
2 dimensions. In our model the islands do not grow in shape, and a fixed number
of adatoms are added, nucleate, and are trapped at islands as they diffuse.
We study the cases of various critical island sizes for nucleation as a
function of initial coverage. We found anomalous scaling of the island size
distribution for large . Using scaling, random walk theory, a version of
mean-field theory we obtain a closed form for the spatial correlation function.
Our analytic results are verified by Monte Carlo simulations
Skyrmion morphology in ultrathin magnetic films
Nitrogen-vacancy magnetic microscopy is employed in quenching mode as a
non-invasive, high resolution tool to investigate the morphology of isolated
skyrmions in ultrathin magnetic films. The skyrmion size and shape are found to
be strongly affected by local pinning effects and magnetic field history.
Micromagnetic simulations including static disorder, based on a physical model
of grain-to-grain thickness variations, reproduce all experimental observations
and reveal the key role of disorder and magnetic history in the stabilization
of skyrmions in ultrathin magnetic films. This work opens the way to an
in-depth understanding of skyrmion dynamics in real, disordered media.Comment: 9 pages, 8 figures, including supplementary information
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