Immunodiagnostics and immune surveillance in an era of evolving immunotherapeutic strategies in AML

Ossenkoppele, G.J. [Promotor]Loosdrecht, A.A. van de [Promotor]Gruijl, T.D. de [Copromotor]Westers, T.M. [Copromotor

The Instability Strip for Pre--Main-Sequence Stars

We investigate the pulsational properties of Pre--Main-Sequence (PMS) stars by means of linear and nonlinear calculations. The equilibrium models were taken from models evolved from the protostellar birthline to the ZAMS for masses in the range 1 to 4 solar masses. The nonlinear analysis allows us to define the instability strip of PMS stars in the HR diagram. These models are used to constrain the internal structure of young stars and to test evolutionary models. We compare our results with observations of the best case of a pulsating young star, HR~5999, and we also identify possible candidates for pulsational variability among known Herbig Ae/Be stars which are located within or close to the instability strip boundaries.Comment: 14 pages, three postscript figures, accepted for publication on the Astrophysical Journal Letter

The X-Ray Origin of Herbig AeBe Systems: New Insights

We present a statistical study of the X-Ray emission toward 22 Herbig AeBe stars using the Chandra archive. We probe the origin of the X-Rays toward Herbig stars: are they intrinsic? This question is addressed by correlations between the physical stellar properties and the X-Ray emission. There is a weak correlation between the continuum radio emission at lambda = 3.6cm and Lx, which suggests that the X-Ray emission depends upon the source. On the other hand, no correlation was found with the stellar rotational period, but that only excludes solar-like magnetic activity as the origin of the X-Rays. Most importantly, the X-Ray luminosity of Herbig AeBe stars have a different distribution than T Tauri stars, suggesting X-Ray emission from an unseen late type star companion can be ruled out with an 80% confidence level. This implies that the Herbig AeBe stars must have magnetic activity. In addition, we report the observation of five sources for the first time, three detections.Comment: 26 pages, 8 figures, accepted for publication in Astronomical Journa

CO ro-vibrational lines in HD100546: A search for disc asymmetries and the role of fluorescence

We have studied the emission of CO ro-vibrational lines in the disc around the Herbig Be star HD100546 with the final goal of using these lines as a diagnostic to understand inner disc structure in the context of planet formation. High-resolution IR spectra of CO ro-vibrational emission at eight different position angles were taken with CRIRES at the VLT. From these spectra flux tables, CO ro-vibrational line profiles, and population diagrams were produced. We have investigated variations in the line profile shapes and line strengths as a function of slit position angle. We used the thermochemical disc modelling code ProDiMo based on the chemistry, radiation field, and temperature structure of a previously published model for HD100546. Comparing observations and the model, we investigated the possibility of disc asymmetries, the excitation mechanism (UV fluorescence), the geometry, and physical conditions of the inner disc. The observed CO ro-vibrational lines are largely emitted from the inner rim of the outer disc at 10-13 AU. The line shapes are similar for all v levels and line fluxes from all vibrational levels vary only within one order of magnitude. All line profile asymmetries and variations can be explained with a symmetric disc model to which a slit correction and pointing offset is applied. Because the angular size of the CO emitting region (10-13 AU) and the slit width are comparable the line profiles are very sensitive to the placing of the slit. The model reproduces the line shapes and the fluxes of the v=1-0 lines as well as the spatial extent of the CO ro-vibrational emission. It does not reproduce the observed band ratios of 0.5-0.2 with higher vibrational bands. We find that lower gas volume densities at the surface of the inner rim of the outer disc can make the fluorescence pumping more effcient and reproduce the observed band ratios.Comment: 20 pages, 21 figure

Silicate Emission in the TW Hydrae Association

The TW Hydrae Association is the nearest young stellar association. Among its members are HD 98800, HR 4796A, and TW Hydrae itself, the nearest known classical T Tauri star. We have observed these three stars spectroscopically between 3 and 13 microns. In TW Hya the spectrum shows a silicate emission feature that is similar to many other young stars with protostellar disks. The 11.2 micron feature indicative of significant amounts of crystalline olivine is not as strong as in some young stars and solar system comets. In HR 4796A, the thermal emission in the silicate feature is very weak, suggesting little in the way of (small silicate) grains near the star. The silicate band of HD 98800 (observed by us but also reported by Sylvester and Skinner (1996)) is intermediate in strength between TW Hya and HR 4796.Comment: 22 pages, 11 figures, LaTeX2e and AAS LaTeX macros v5.0. Accepted for publication in A

Candidate Pre-Mainsequence F Stars with Circumstellar Dust Identified Using Combined 2MASS and uvby Data

We propose a method that uses near-infrared plus uvby photometry to identify potentially extensive circumstellar dusty environment about F and A stars. The method has been applied to a sample of ~900 metal rich reddened F stars with 2MASS and uvby data, suggesting the presence of circumstellar dust emitting in the near infrared for ~70 stars. The log T_e - M_V diagram suggests that most, if not all, of them are likely pre-mainsequence (PMS). They seem to be consistent with being a continuation of the class of Herbig Ae/Be PMS stars into the spectral type F. Their number drops sharply downward of log T_e ~ 3.84 (spectral types later than ~F5), which may provide new clues to the PMS evolution of stars with 1 to 2 solar mass. We present a list of 21 most conspicuous candidate stars with circumstellar dust. About half of them are associated with the extended star-forming region around rho Oph. The brightest of these 21 stars, with V < 7.5, turn out to be IRAS sources, suggesting the presence of heated dust emitting in the far infrared. Also in this list, HD 81270 is reported as a very unusual star moving away from the Galactic plane at a projected speed of 70 km/sec.Comment: 8 pages, 4 figures, 1 table. To appear in ApJ, part 2, v. 570, 2002 May

H_2 and CO Emission from Disks around T Tauri and Herbig Ae Pre-Main-Sequence Stars and from Debris Disks around Young Stars: Warm and Cold Circumstellar Gas

We present ISO Short-Wavelength Spectrometer observations of H_2 pure-rotational line emission from the disks around low- and intermediate-mass pre-main-sequence stars as well as from young stars thought to be surrounded by debris disks. The pre-main-sequence sources have been selected to be isolated from molecular clouds and to have circumstellar disks revealed by millimeter interferometry. We detect "warm" (T ≈100-200 K) H_2 gas around many sources, including tentatively the debris-disk objects. The mass of this warm gas ranges from ~ 10^(-4) M_☉ up to 8 x 10^(-3) and can constitute a nonnegligible fraction of the total disk mass. Complementary single-dish ^(12)CO 3-2/^(13)CO 3-2, and ^(12)CO 6-5 observations have been obtained as well. These transitions probe cooler gas at T ≈ 20-80 K. Most objects show a double-peaked CO emission profile characteristic of a disk in Keplerian rotation, consistent with interferometer data on the lower J lines. The ratios of the ^(12)CO 3-2/^(13)CO 3-2 integrated fluxes indicate that ^(12)CO 3-2 is optically thick but that ^(13)CO 3-2 is optically thin or at most moderately thick. The ^(13)CO 3-2 lines have been used to estimate the cold gas mass. If a H_2/CO conversion factor of 1 x 10^(-4) is adopted, the derived cold gas masses are factors of 10-200 lower than those deduced from 1.3 millimeter dust emission assuming a gas/dust ratio of 100, in accordance with previous studies. These findings confirm that CO is not a good tracer of the total gas content in disks since it can be photodissociated in the outer layers and frozen onto grains in the cold dense part of disks, but that it is a robust tracer of the disk velocity field. In contrast, H_2 can shield itself from photodissociation even in low-mass "optically thin" debris disks and can therefore survive longer. The warm gas is typically 1%-10% of the total mass deduced from millimeter continuum emission, but it can increase up to 100% or more for the debris-disk objects. Thus, residual molecular gas may persist into the debris-disk phase. No significant evolution in the H_2 CO, or dust masses is found for stars with ages in the range of 10^6-10^7 yr, although a decrease is found for the older debris-disk star β Pictoris. The large amount of warm gas derived from H_2 raises the question of the heating mechanism(s). Radiation from the central star as well as the general interstellar radiation field heat an extended surface layer of the disk, but existing models fail to explain the amount of warm gas quantitatively. The existence of a gap in the disk can increase the area of material influenced by radiation. Prospects for future observations with ground- and space-borne observations are discussed