Testosterone facilitates the sense of agency

Sense of agency (SoA) refers to feelings of being in control of one's actions. Evidence suggests that SoA might contribute towards higher-order feelings of personal control - a key attribute of powerful individuals. Whether testosterone, a steroid hormone linked to power in dominance hierarchies, also influences the SoA is not yet established. In a repeated-measures design, 26 females participated in a double-blind, placebo-controlled trial to test the effects of 0.5 mg testosterone on SoA, using an implicit measure based upon perceived shifts in time between a voluntary action and its outcome. Illusions of control, as operationalized by optimism in affective forecasting, were also assessed. Testosterone increased action binding but there was no significant effect on tone binding. Affective forecasting was found to be significantly more positive on testosterone. SoA and optimistic expectations are basic manifestations of power which may contribute to feelings of infallibility often associated with dominance and testosterone

A Neuropsychoanalytical approach to the hard problem of consciousness

A neuropsychoanalytical approach to the ‘hard problem’ of consciousness revolves around the distinction between the subject and objects of consciousness. In contrast to the mainstream of cognitive science, neuropsychoanalysis prioritises the subject. The subject of consciousness is the indispensable page upon which its objects are inscribed. This has implications for our conception of the mental. The subjective being of consciousness is not registered in the classical exteroceptive modalities; it is not a cognitive representation, not a memory trace. Cognitive representations are ‘mental solids,’ embedded within subjective consciousness, and their tangible and visible (etc.) properties are projected onto reality. It is important to recognise that mental solids (e.g. the body-as-object) are no more real than the subjective being they are represented in (the body-as-subject). Moreover, pure subjectivity is not without content or quality. This aspect of consciousness is conventionally described quantitatively as the level of consciousness, ‘wakefulness’. But it feels like something to be awake. The primary modality of this aspect of consciousness is affect. Some implications of this frame of reference are discussed here, in broad brush strokes. This is an electronic version of an article published as Journal of Integrative Neuroscience, Volume 13, Issue 2, 2014, pp. 173-185. DOI: http://dx.doi.org/10.1142/S0219635214400032, © World Scientific Publishing Company, http://www.worldscientific.com/worldscinet/jin

Sex and sexuality: An evolutionary view

In this article, I first offer a summary of Darwin’s main ideas, especially relating to sex, and explain how these have been elaborated by more recent evolutionary scholars. I then give an account of the historical divergence between psychoanalysis and classical Darwinian thought, and describe how the early psychoanalyst Sabina Spielrein tried to counter this by addressing some biological themes in her work. Following a review of some contemporary attempts to bring psychoanalysis and evolutionary thought into alignment with each other, I make some suggestions regarding a view of sex and sexuality that would be sound in evolutionary terms while also being helpful in psychoanalytic ones

2021 Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulants

International audienceIn 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice

Transferable Constant-Size Fair E-Cash

International audienceWe propose a new blind certification protocol that provides interesting properties while remaining efficient. It falls in the Groth-Sahai framework for witness-indistinguishable proofs, thus extended to a certified signature it immediately yields non-frameable group signatures. We then use it to build an efficient (offline) e-cash system that guarantees user anonymity and transferability of coins without increasing their size. As required for fair e-cash, in case of fraud, anonymity can be revoked by an authority, which is also crucial to deter from double spending