100,563 research outputs found
Metal cooldown, flow instability, and heat transfer in two-phase hydrogen flow
Studies of the properties of five metals with varying tube-wall thickness, with or without and internal coating of trifluorochloroethylene polymer, show that wall characteristics influence flow stability, affect heat transfer coefficients, and influence the transition point from dry- to wet-wall flow
Giant Antiferromagnetically Coupled Moments in a Molecule-Based Magnet with Interpenetrating Lattices
The molecule-based magnet [Ru(OCMe)][Cr(CN)] contains two
weakly-coupled, interpenetrating sublattices in a body-centered cubic
structure. Although the field-dependent magnetization indicates a metamagnetic
transition from an antiferromagnet to a paramagnet, the hysteresis loop also
exhibits a substantial magnetic remanance and coercive field uncharacteristic
of a typical metamagnet. We demonstrate that this material behaves like two
giant moments with a weak antiferromagnetic coupling and a large energy barrier
between the orientations of each moment. Because the sublattice moments only
weakly depend on field in the transition region, the magnetic correlation
length can be directly estimated from the magnetization.Comment: 3 figure
Numerical methods for the design and analysis of wings at supersonic speeds
Numerical methods for the design and analysis of arbitrary-planform wings at supersonic speeds are reviewed. Certain deficiencies are revealed, particularly in application to wings with slightly subsonic leading edges. Recently devised numerical techniques which overcome the major part of these deficiencies are presented. The original development as well as the more recent revisions are subjected to a thorough review
Integrability, Stäckel spaces, and rational potentials
For a variety of classical mechanical systems embeddable into flat space with Cartesian coordinates {xi} and for which the Hamilton–Jacobi equation can be solved via separation of variables in a particular curvalinear system {uj}, we answer the following question. When is the separable potential function v expressible as a polynomial (or as a rational function) in the defining coordinates {xi}? Many examples are given
Geologic application of thermal-inertia mapping from satellite
The author has identified the following significant results. Two night-time thermal images of the Powder River Basin, Wyoming distinctly show a major thermal feature. This feature is substantially coincident with a drainage divide and the southward facing slope appears cooler, suggesting a lower thermal inertia. An initial examination of regional geologic maps provides no clear evidence to suggest what type of geologic feature or structure may be present, although it can be noted that its northeastern end passes directly through Lead, South Dakota where the Homestake Gold Mine is located
An investigation of the observability of ocean-surface parameters using GEOS-3 backscatter data
The degree to which ocean surface roughness can be synoptically observed through use of the information extracted from the GEOS-3 backscattered waveform data was evaluated. Algorithms are given for use in estimating the radar sensed waveheight distribution or ocean-surface impulse response. Other factors discussed include comparisons between theoretical and experimental radar cross section values, sea state bias effects, spatial variability of significant waveheight data, and sensor-related considerations
A linearized theory method of constrained optimization for supersonic cruise wing design
A linearized theory wing design and optimization procedure which allows physical realism and practical considerations to be imposed as constraints on the optimum (least drag due to lift) solution is discussed and examples of application are presented. In addition to the usual constraints on lift and pitching moment, constraints are imposed on wing surface ordinates and wing upper surface pressure levels and gradients. The design procedure also provides the capability of including directly in the optimization process the effects of other aircraft components such as a fuselage, canards, and nacelles
Trogocytosis by Entamoeba histolytica Mediates Acquisition and Display of Human Cell Membrane Proteins and Evasion of Lysis by Human Serum.
We previously showed that Entamoeba histolytica kills human cells through a mechanism that we termed trogocytosis ("trogo-" means "nibble"), due to its resemblance to trogocytosis in other organisms. In microbial eukaryotes like E. histolytica, trogocytosis is used to kill host cells. In multicellular eukaryotes, trogocytosis is used for cell killing and cell-cell communication in a variety of contexts. Thus, nibbling is an emerging theme in cell-cell interactions both within and between species. When trogocytosis occurs between mammalian immune cells, cell membrane proteins from the nibbled cell are acquired and displayed by the recipient cell. In this study, we tested the hypothesis that through trogocytosis, amoebae acquire and display human cell membrane proteins. We demonstrate that E. histolytica acquires and displays human cell membrane proteins through trogocytosis and that this leads to protection from lysis by human serum. Protection from human serum occurs only after amoebae have undergone trogocytosis of live cells but not phagocytosis of dead cells. Likewise, mutant amoebae defective in phagocytosis, but unaltered in their capacity to perform trogocytosis, are protected from human serum. Our studies are the first to reveal that amoebae can display human cell membrane proteins and suggest that the acquisition and display of membrane proteins is a general feature of trogocytosis. These studies have major implications for interactions between E. histolytica and the immune system and also reveal a novel strategy for immune evasion by a pathogen. Since other microbial eukaryotes use trogocytosis for cell killing, our findings may apply to the pathogenesis of other infections.IMPORTANCE Entamoeba histolytica causes amoebiasis, a potentially fatal diarrheal disease. Abscesses in organs such as the liver can occur when amoebae are able to breach the intestinal wall and travel through the bloodstream to other areas of the body. Therefore, understanding how E. histolytica evades immune detection is of great interest. Here, we demonstrate for the first time that E. histolytica acquires and displays human cell membrane proteins by taking "bites" of human cell material in a process named trogocytosis ("trogo-" means "nibble"), and that this allows amoebae to survive in human serum. Display of acquired proteins through trogocytosis has been previously characterized only in mammalian immune cells. Our study suggests that this is a more general feature of trogocytosis not restricted to immune cells and broadens our knowledge of eukaryotic biology. These findings also reveal a novel strategy for immune evasion by a pathogen and may apply to the pathogenesis of other infections
Phenolic cutter for machining foam insulation
Pre-pregged fiber glass is an efficient abrasive for machining polystyrene and polyurethane foams. It bonds easily to any cutter base made of aluminum, steel, or phenolic, is inexpensive, and is readily available
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