44 research outputs found

    Nat. Struct. Mol. Biol.

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    Metric analysis of the lumbar region of human vertebral column

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    Detailed measurement of lumbar spine, despite the many years of study, still provides new information, especially due to low back pain, which is increasing and unresolved worldwide health problem. This review includes historical background and evolution of measurement methods. The paper also focused on searching optimal animal model of lumbar spine and summarizes current knowledge and essential tips. In addition, practical application of lumbar metric analysis was presented. This summary is a starting point for further consideration

    Notatki przyrodnicze. Pajeczaki.

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    RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

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    A state-of-the-art microscopy-based RNAi screen for potential cell cycle roles of human DNA damage-binding 1–Cul4-associated factors, substrate adaptors associated with DDB1-cullin 4-based ubiquitin ligases, reveals a homologue of the yeast genome stability factor Mms22 to be required for DNA replication. Interestingly, human Mms22-like protein appears not to be a subunit, but rather a substrate, of the cullin 4 complex
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