Symbol table algorithms - Computer evolution project, volume 2, no. 1

Algorithms for accessing symbol tables in compile

Mendocino power plant site ecological study, Quarterly Report No. 1; July 1 - September 30, 1971

This report is the first quarterly report submitted in partial fulfillment of Research Contract No. S-1902 between the Department of Fish and Game and the Pacific Gas and Electric Company. Through this contract the Department of Fish and Game is to conduct a pre-operational ecological study to establish a base line inventory of the marine biota with special reference to fish and to abalone, including food chains. Quarterly reports will be followed by annual reports. The first annual report will cover all work from September 1971 through December 1972. Full tables and species lists will be included in each annual report

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex

Matrix Metalloproteinases and Glaucoma Treatment.

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in health and disease. The activity of MMPs is influenced by the expression of MMPs and tissue inhibitors of metalloproteinase (TIMPs). In the eye, MMP-mediated ECM turnover in the juxtacanalicular region of the trabecular meshwork (TM) reduces outflow resistance in the conventional outflow pathway and helps maintain intraocular pressure (IOP) homeostasis. An imbalance in the MMP/TIMP ratio may be involved in the elevated IOP often associated with glaucoma. The prostaglandin analog/prostamide (PGA) class of topical ocular hypotensive medications used in glaucoma treatment reduces IOP by increasing outflow through both conventional and unconventional (uveoscleral) outflow pathways. Evidence from in vivo and in vitro studies using animal models and anterior segment explant and cell cultures indicates that the mechanism of IOP lowering by PGAs involves increased MMP expression in the TM and ciliary body, leading to tissue remodeling that enhances conventional and unconventional outflow. PGA effects on MMP expression are dependent on the identity and concentration of the PGA. An intracameral sustained-release PGA implant (Bimatoprost SR) in development for glaucoma treatment can reduce IOP for many months after expected intraocular drug bioavailability. We hypothesize that the higher concentrations of bimatoprost achieved in ocular outflow tissues with the implant produce greater MMP upregulation and more extensive, sustained MMP-mediated target tissue remodeling, providing an extended duration of effect

Probability Density in the Complex Plane

The correspondence principle asserts that quantum mechanics resembles classical mechanics in the high-quantum-number limit. In the past few years many papers have been published on the extension of both quantum mechanics and classical mechanics into the complex domain. However, the question of whether complex quantum mechanics resembles complex classical mechanics at high energy has not yet been studied. This paper introduces the concept of a local quantum probability density $\rho(z)$ in the complex plane. It is shown that there exist infinitely many complex contours $C$ of infinite length on which $\rho(z) dz$ is real and positive. Furthermore, the probability integral $\int_C\rho(z) dz$ is finite. Demonstrating the existence of such contours is the essential element in establishing the correspondence between complex quantum and classical mechanics. The mathematics needed to analyze these contours is subtle and involves the use of asymptotics beyond all orders.Comment: 38 pages, 17figure

Mendocino power plant site ecological study, Quarterly Report No. 5; July 1 - September 30, 1972

This report is the fifth quarterly report submitted in partial fulfillment of Research Contract No. S-1902 between the Department of Fish and Game and the Pacific Gas and Electric Company. Through this contract the Department of Fish and Game is to conduct a pre-operational ecological study to establish a base line inventory of the marine biota with special reference to fish and to abalone, including food chains. Quarterly reports will be followed by annual reports. The first annual report will cover all work from September 1971 through December 1972. Full tables and species lists will be included in each annual report

Mendocino Power Plant site ecological study annual report; July 1, 1971 to December 31, 1972

This report is the first annual report submitted in partial fulfillment of Research Contract No. S-1902 between the Department of Fish and Game and the Pacific Gas and Electric Company. Through this contract the Department of Fish and Game is to conduct a preoperational ecological study to establish a base line inventory of the marine biota with special reference to fish and to abalone, including food chains. This first annual report covers all work from September 1971 through December 1972. This annual report covers the first 18 month period of the project from July 1, 1971 through December 31, 1972. The report includes results (discussion and tables) of our subtidal, intertidal, sportfishery, fish collection, fish food habit, and plankton studies. The quarterly report for October 1 to December 31, 1972 is included herein and these data are incorporated in this annual report. (86pp.

Scalable iterative methods for sampling from massive Gaussian random vectors

Sampling from Gaussian Markov random fields (GMRFs), that is multivariate Gaussian ran- dom vectors that are parameterised by the inverse of their covariance matrix, is a fundamental problem in computational statistics. In this paper, we show how we can exploit arbitrarily accu- rate approximations to a GMRF to speed up Krylov subspace sampling methods. We also show that these methods can be used when computing the normalising constant of a large multivariate Gaussian distribution, which is needed for both any likelihood-based inference method. The method we derive is also applicable to other structured Gaussian random vectors and, in particu- lar, we show that when the precision matrix is a perturbation of a (block) circulant matrix, it is still possible to derive O(n log n) sampling schemes.Comment: 17 Pages, 4 Figure

Self-contained Kondo effect in single molecules

Kondo coupling of f and conduction electrons is a common feature of f-electron intermetallics. Similar effects should occur in carbon ring systems(metallocenes). Evidence for Kondo coupling in Ce(C8H8)2 (cerocene) and the ytterbocene Cp*2Yb(bipy) is reported from magnetic susceptibility and L_III-edge x-ray absorption spectroscopy. These well-defined systems provide a new way to study the Kondo effect on the nanoscale, should generate insight into the Anderson Lattice problem, and indicate the importance of this often-ignored contribution to bonding in organometallics.Comment: 4 pages, 5 figures (eps

The Availability of Injunctive Relief in Commercial Disputes

Article published in the Michigan Bar Journal