13,855 research outputs found
Gas Purity effect on GEM Performance in He and Ne at Low Temperatures
The performance of Gas Electron Multipliers (GEMs) in gaseous He, Ne, He+H2
and Ne+H2 was studied at temperatures in the range of 3-293 K. This paper
reports on previously published measurements and additional studies on the
effects of the purity of the gases in which the GEM performance is evaluated.
In He, at temperatures between 77 and 293 K, triple-GEM structures operate at
rather high gains, exceeding 1000. There is an indication that this high gain
is achieved through the Penning effect as a result of impurities in the gas. At
lower temperatures the gain-voltage characteristics are significantly modified
probably due to the freeze-out of these impurities. Double-GEM and single-GEM
structures can operate down to 3 K at gains reaching only several tens at a gas
density of about 0.5 g/l; at higher densities the maximum gain drops further.
In Ne, the maximum gain also drops at cryogenic temperatures. The gain drop in
Ne at low temperatures can be re-established in Penning mixtures of Ne+H2: very
high gains, exceeding 104, have been obtained in these mixtures at 30-77 K, at
a density of 9.2 g/l which corresponds to saturated Ne vapor density at 27 K.
The addition of small amounts of H2 in He also re-establishes large GEM gains
above 30 K but no gain was observed in He+H2 at 4 K and a density of 1.7 g/l
(corresponding to roughly one-tenth of the saturated vapor density). These
studies are, in part, being pursued in the development of two-phase He and Ne
detectors for solar neutrino detection.Comment: 4 pages, 7 figure
Approximate Minimum Diameter
We study the minimum diameter problem for a set of inexact points. By
inexact, we mean that the precise location of the points is not known. Instead,
the location of each point is restricted to a contineus region (\impre model)
or a finite set of points (\indec model). Given a set of inexact points in
one of \impre or \indec models, we wish to provide a lower-bound on the
diameter of the real points.
In the first part of the paper, we focus on \indec model. We present an
time
approximation algorithm of factor for finding minimum diameter
of a set of points in dimensions. This improves the previously proposed
algorithms for this problem substantially.
Next, we consider the problem in \impre model. In -dimensional space, we
propose a polynomial time -approximation algorithm. In addition, for
, we define the notion of -separability and use our algorithm for
\indec model to obtain -approximation algorithm for a set of
-separable regions in time
ESR Study of (C_5H_{12}N)_2CuBr_4
ESR studies at 9.27, 95.4, and 289.7 GHz have been performed on
(CHN)CuBr down to 3.7 K. The 9.27 GHz data were acquired
with a single crystal and do not indicate the presence of any structural
transitions. The high frequency data were collected with a polycrystalline
sample and resolved two absorbances, consistent with two crystallographic
orientations of the magnetic sites and with earlier ESR studies performed at
300 K. Below T, our data confirm the presence of a spin singlet
ground state.Comment: 2 pages, 4 figs., submitted 23rd International Conference on Low
Temperature Physics (LT-23), Aug. 200
Criminal Justice and Suicide Outcomes with Indiana's Risk-Based Gun Seizure Law
This article examines the application and effectiveness of a 2006 Indiana law designed to prevent gun violence by authorizing police officers to separate firearms from persons who present imminent or future risk of injury to self or others, or display a propensity for violent or emotionally unstable conduct. A court hearing is held to determine ongoing risk in these cases; a judge decides whether to return the seized firearms or retain them for up to five years. The study examines the frequency of criminal arrest as well as suicide outcomes for 395 gun-removal actions in Indiana. Fourteen individuals (3.5%) died from suicide, seven (1.8%) using a firearm. The study population's annualized suicide rate was about 31 times higher than that of the general adult population in Indiana, demonstrating that the law is being applied to a population genuinely at high risk. By extrapolating information on the case fatality rate for different methods of suicide, we calculated that one life was saved for every 10 gun-removal actions, similar to results of a previous study in Connecticut. Perspectives from key stakeholders are also presented along with implications for gun policy reform and implementation
A chiral HPLC-MS/MS method for simultaneous quantification of warfarin enantiomers and its major hydroxylation metabolites of CYP2C9 and CYP3A4 in human plasma
Warfarin is an oral anticoagulant that requires frequent therapeutic drug monitoring due to a narrow therapeutic window, considerable interindividual variability in drug response, and susceptibility to drug-drug and drug-diet interactions. Enantiomeric separation and quantification of warfarin enantiomers and clinically important major hydroxylation metabolites are essential for drug interaction studies and phenotypic characterization of CYP2C9 and CYP3A4, the major Cytochrome P450 (CYP) enzymes involved in warfarin metabolism. Here, we describe the development and validation of a chiral high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)-based quantification of R-warfarin, S-warfarin, S-7-hydroxywarfarin (the major CYP2C9metabolite) and (9R; 10S)-10-hydroxywarfarin (the CYP3A4 metabolite) in human plasma. Simple protein precipitation-based extraction showed good recovery of analytes (82.9 - 96.9%). The developed method exhibited satisfactory
intra-day and inter-day accuracy and precision. The lower limits of detection were 0.25nM (or ~0.08 ng/ml) for the warfarin enantiomers and 0.1nM (or ~0.04 ng/mL) for S-7-hydroxywarfarinand (9R; 10S)-10-hydroxywarfarin using only
50μL plasma during extraction. The validated method was successfully applied to analyze plasma samples obtained from a healthy human subject who enrolled in a clinical drug interaction study involving warfarin
Infrared conductivity of hole accumulation and depletion layers in (Ga,Mn)As- and (Ga,Be)As-based electric field-effect devices
We have fabricated electric double-layer field-effect devices to
electrostatically dope our active materials, either =0.015
GaMnAs or =3.2 GaBeAs. The devices
are tailored for interrogation of electric field induced changes to the
frequency dependent conductivity in the accumulation or depletions layers of
the active material via infrared (IR) spectroscopy. The spectra of the
(Ga,Be)As-based device reveal electric field induced changes to the IR
conductivity consistent with an enhancement or reduction of the Drude response
in the accumulation and depletion polarities, respectively. The spectroscopic
features of this device are all indicative of metallic conduction within the
GaAs host valence band (VB). For the (Ga,Mn)As-based device, the spectra show
enhancement of the far-IR itinerant carrier response and broad mid-IR resonance
upon hole accumulation, with a decrease of these features in the depletion
polarity. These later spectral features demonstrate that conduction in
ferromagnetic (FM) GaMnAs is distinct from genuine metallic
behavior due to extended states in the host VB. Furthermore, these data support
the notion that a Mn-induced impurity band plays a vital role in the electron
dynamics of FM GaMnAs. We add, a sum-rule analysis of the spectra
of our devices suggests that the Mn or Be doping does not lead to a substantial
renormalization of the GaAs host VB
Elementary amenable subgroups of R. Thompson's group F
The subgroup structure of Thompson's group F is not yet fully understood. The
group F is a subgroup of the group PL(I) of orientation preserving, piecewise
linear self homeomorphisms of the unit interval and this larger group thus also
has a poorly understood subgroup structure. It is reasonable to guess that F is
the "only" subgroup of PL(I) that is not elementary amenable. In this paper, we
explore the complexity of the elementary amenable subgroups of F in an attempt
to understand the boundary between the elementary amenable subgroups and the
non-elementary amenable. We construct an example of an elementary amenable
subgroup up to class (height) omega squared, where omega is the first infinite
ordinal.Comment: 20 page
Exact quantization of a PT-symmetric (reversible) Li\'enard-type nonlinear oscillator
We carry out an exact quantization of a PT symmetric (reversible) Li\'{e}nard
type one dimensional nonlinear oscillator both semiclassically and quantum
mechanically. The associated time independent classical Hamiltonian is of
non-standard type and is invariant under a combined coordinate reflection and
time reversal transformation. We use von Roos symmetric ordering procedure to
write down the appropriate quantum Hamiltonian. While the quantum problem
cannot be tackled in coordinate space, we show how the problem can be
successfully solved in momentum space by solving the underlying Schr\"{o}dinger
equation therein. We obtain explicitly the eigenvalues and eigenfunctions (in
momentum space) and deduce the remarkable result that the spectrum agrees
exactly with that of the linear harmonic oscillator, which is also confirmed by
a semiclassical modified Bohr-Sommerfeld quantization rule, while the
eigenfunctions are completely different.Comment: 10 pages, 1 figure, Fast Track Communicatio
Sensitivity of estimated total canopy SIF emission to remotely sensed LAI and BRDF products
Remote sensing of solar-induced chlorophyll fluorescence (SIF) provides new possibilities to estimate terrestrial gross primary production (GPP). To mitigate the angular and canopy structural effects on original SIF observed by sensors (SIFobs), it is recommended to derive total canopy SIF emission (SIFtotal) of leaves within a canopy using canopy interception (i0) and reflectance of vegetation (RV). However, the effects of the uncertainties in i0 and RV on the estimation of SIFtotal have not been well understood. Here, we evaluated such effects on the estimation of GPP using the Soil-Canopy-Observation of Photosynthesis and the Energy balance (SCOPE) model. The SCOPE simulations showed that the R2 between GPP and SIFtotal was clearly higher than that between GPP and SIFobs and the differences in R2 (ΔR2) tend to decrease with the increasing levels of uncertainties in i0 and RV. The resultant ΔR2 decreased to zero when the uncertainty level in i0 and RV was ~30% for red band SIF (RSIF, 683 nm) and ~20% for far-red band SIF (FRSIF, 740 nm). In addition, as compared to the TROPOspheric Monitoring Instrument (TROPOMI) SIFobs at both red and far-red bands, SIFtotal derived using any combination of i0 (from MCD15, VNP15, and CGLS LAI products) and RV (from MCD34, MCD19, and VNP43 BRDF products) showed comparable improvements in estimating GPP. With this study, we suggest a way to advance our understanding in the estimation of a more physiological relevant SIF datasets (SIFtotal) using current satellite products
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