Audit Costs for the 1986 Texas Energy Cost Containment Program

Direct program costs for detailed audits of 13.5 million square feet of institutional building space in the 1986 Texas Energy Cost Containment Program were $0.047/SF. The building area was 63 percent simple (offices, schools, and universities) and 37 percent complex (medical buildings and power plants). Allowing for the influence of one large facility which received less-extensive treatment due to previous work, thorough audits were obtained for an average cost of$0.050/SF. Large medical buildings (greater than about 170,000 square feet) were audited for $0.050/SF or less, and program costs for survey audits of 17.2 million square feet were$0.0028/SF. The effect on audit costs of complexity of recommended modifications, amount of savings determined, amount of implementation costs, building size, and building complexity are discussed. Primary effects on audit costs are size and complexity of buildings. Program guidelines limited consideration of projects with greater than a four year payback

Electrochemical CO reduction builds solvent water into oxygenate products

Numerous studies have examined the electrochemical reduction of CO (COR) to oxygenates (e.g., ethanol). None have considered the possibility that oxygen in the product might arise from water rather than from CO. To test this assumption, C^(16)O reduction was performed in H_2^(18)O electrolyte. Surprisingly, we found that 60–70% of the ethanol contained 18O, which must have originated from the solvent. We extended our previous all-solvent density functional theory metadynamics calculations to consider the possibility of incorporating water, and indeed, we found a new mechanism involving a Grotthuss chain of six water molecules in a concerted reaction with the *C–CH intermediate to form *CH–CH(^(18)OH), subsequently leading to (^(18)O)ethanol. This competes with the formation of ethylene that also arises from *C–CH. These unforeseen results suggest that all previous studies of COR under aqueous conditions must be reexamined

Thermodynamics, Structure, and Dynamics of Water Confined between Hydrophobic Plates

We perform molecular dynamics simulations of 512 water-like molecules that interact via the TIP5P potential and are confined between two smooth hydrophobic plates that are separated by 1.10 nm. We find that the anomalous thermodynamic properties of water are shifted to lower temperatures relative to the bulk by $\approx 40$ K. The dynamics and structure of the confined water resemble bulk water at higher temperatures, consistent with the shift of thermodynamic anomalies to lower temperature. Due to this $T$ shift, our confined water simulations (down to $T = 220$ K) do not reach sufficiently low temperature to observe a liquid-liquid phase transition found for bulk water at $T\approx 215$ K using the TIP5P potential. We find that the different crystalline structures that can form for two different separations of the plates, 0.7 nm and 1.10 nm, have no counterparts in the bulk system, and discuss the relevance to experiments on confined water.Comment: 31 pages, 14 figure

Factores de riesgo de Enfermedades Crónicas no Transmisibles en Estudiantes de Enfermería del Centro Regional Universitario de Azuero. II Semestre 2006

El presente estudio es de tipo descriptivo transversal, realizado en los estudiantes de la Facultad de Enfermería del Centro Regional Universitario de Azuero, en el II semestre 2006 y se realizó con el propósito de estimar la prevalencia de los principales factores de riesgo de las enfermedades crónicas no transmisibles en estudiantes de enfermería. Luego de analizar estadísticamente sus valores, se encontró que el factor de riesgo de mayor prevalencia fue: inactividad física, el bajo consumo de frutas, bajo consumo de vegetales, antecedentes de enfermedades crónicas.Universidad de Costa RicaUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Enfermerí

DNA-Based Authentication of Botanicals and Plant-Derived Dietary Supplements: Where Have We Been and Where Are We Going?

Herbal medicines and botanicals have long been used as sole or additional medical aids worldwide. Currently, billions of dollars are spent on botanicals and related products, but minimal regulation exists regarding their purity, integrity, and efficacy. Cases of adulteration and contamination have led to severe illness and even death in some cases. Identifying the plant material in botanicals and phytomedicines using organoleptic means or through microscopic observation of plant parts is not trivial, and plants are often misidentified. Recently, DNA-based methods have been applied to these products because DNA is not changed by growth conditions unlike the chemical constituents of many active pharmaceutical agents. In recent years, DNA barcoding methods, which are used to identify species diversity in the Tree of Life, have been also applied to botanicals and plant-derived dietary supplements. In this review, we recount the history of DNA-based methods for identification of botanicals and discuss some of the difficulties in defining a specific bar code or codes to use. In addition, we describe how next generation sequencing technologies have enabled new techniques that can be applied to identifying these products with greater authority and resolution. Lastly, we present case histories where dietary supplements, decoctions, and other products have been shown to contain materials other than the main ingredient stipulated on the label. We conclude that there is a fundamental need for greater quality control in this industry, which if not self-imposed, that may result from legislation

An Inward-Facing Conformation of a Putative Metal-Chelate–Type ABC Transporter

The crystal structure of a putative metal-chelate–type adenosine triphosphate (ATP)–binding cassette (ABC) transporter encoded by genes HI1470 and HI1471 of Haemophilus influenzae has been solved at 2.4 angstrom resolution. The permeation pathway exhibits an inward-facing conformation, in contrast to the outward-facing state previously observed for the homologous vitamin B12 importer BtuCD. Although the structures of both HI1470/1 and BtuCD have been solved in nucleotide-free states, the pairs of ABC subunits in these two structures differ by a translational shift in the plane of the membrane that coincides with a repositioning of the membrane-spanning subunits. The differences observed between these ABC transporters involve relatively modest rearrangements and may serve as structural models for inward- and outward-facing conformations relevant to the alternating access mechanism of substrate translocation

Faculty-Wide Peer-Support Program During the COVID-19 Pandemic: Design and Preliminary Results

Background: Physicians experience higher rates of burnout relative to the general population. Concerns of confidentiality, stigma, and professional identities as health care providers act as barriers to seeking and receiving appropriate support. In the context of the COVID-19 pandemic, factors that contribute to burnout and barriers to seeking support have been amplified, elevating the overall risks of mental distress and burnout for physicians. Objective: This paper aimed to describe the rapid development and implementation of a peer support program within a health care organization located in London, Ontario, Canada. Methods: A peer support program leveraging existing infrastructures within the health care organization was developed and launched in April 2020. The “Peers for Peers” program drew from the work of Shapiro and Galowitz in identifying key components within hospital settings that contributed to burnout. The program design was derived from a combination of the peer support frameworks from the Airline Pilot Assistance Program and the Canadian Patient Safety Institute. Results: Data gathered over 2 waves of peer leadership training and program evaluations highlighted a diversity of topics covered through the peer support program. Further, enrollment continued to increase in size and scope over the 2 waves of program deployments into 2023. Conclusions: Findings suggest that the peer support program is acceptable to physicians and can be easily and feasibly implemented within a health care organization. The structured program development and implementation can be adopted by other organizations in support of emerging needs and challenge

Additional Comparison of Iced Aerodynamic Measurements on a Swept Wing from Two Wind Tunnels

Artificial ice shapes of various geometric fidelity were tested on a wing model based on the Common Research Model. Low Reynolds number test were conducted at Wichita State University's Walter H. Beech Memorial Wind utilizing an 8.9% scale model, and high Reynolds number tests were conducted at ONERA's F1 wind tunnel utilizing a 13.3% scale model. Several identical geometrically-scaled ice shapes were tested at both facilities, and the results were compared at overlapping Reynolds and Mach numbers. This was to ensure that the results and trends observed at low Reynolds number could be applied and continued to high, near-flight Reynolds number. The data from Wichita State University and ONERA F1 agreed well at matched Reynolds and Mach numbers. The lift and pitching moment curves agreed very well for most configurations. This confirmed results from previous tests with other ice shapes that indicated the data from the low Reynolds number tests could be used to understand ice-swept-wing aerodynamics at high Reynolds number. This allows ice aerodynamics testing to be performed at low Reynolds number facilities with much lower operating costs and generate results that are applicable to flight Reynolds number