Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation

<b>Background</b>: The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presence of thiocyanate. <b>Aims</b>: To assess the effect of lipid and ascorbic acid on the nitrosative chemistry under conditions simulating the human proximal stomach. <b>Methods</b>: The nitrosative chemistry was modelled in vitro by measuring the nitrosation of four secondary amines under conditions simulating the proximal stomach. The N-nitrosamines formed were measured by gas chromatography–ion-trap tandem mass spectrometry, while nitric oxide and oxygen levels were measured amperometrically. <b>Results</b>: In absence of lipid, nitrosative stress was inhibited by ascorbic acid through conversion of nitrosating species to nitric oxide. Addition of ascorbic acid reduced the amount of N-nitrosodimethylamine formed by fivefold, N-nitrosomorpholine by .1000-fold, and totally prevented the formation of N-nitrosodiethylamine and N-nitrosopiperidine. In contrast, when 10% lipid was present, ascorbic acid increased the amount of Nnitrosodimethylamine, N-nitrosodiethylamine and N-nitrosopiperidine formed by approximately 8-, 60- and 140-fold, respectively, compared with absence of ascorbic acid. <b>Conclusion</b>: The presence of lipid converts ascorbic acid from inhibiting to promoting acid nitrosation. This may be explained by nitric oxide, formed by ascorbic acid in the aqueous phase, being able to regenerate nitrosating species by reacting with oxygen in the lipid phase

Trapping cold atoms near carbon nanotubes: thermal spin flips and Casimir-Polder potential

We investigate the possibility to trap ultracold atoms near the outside of a metallic carbon nanotube (CN) which we imagine to use as a miniaturized current-carrying wire. We calculate atomic spin flip lifetimes and compare the strength of the Casimir-Polder potential with the magnetic trapping potential. Our analysis indicates that the Casimir-Polder force is the dominant loss mechanism and we compute the minimum distance to the carbon nanotube at which an atom can be trapped.Comment: 8 pages, 3 figure

Size Effects in Carbon Nanotubes

The inter-shell spacing of multi-walled carbon nanotubes was determined by analyzing the high resolution transmission electron microscopy images of these nanotubes. For the nanotubes that were studied, the inter-shell spacing ${\hat{d}_{002}}$ is found to range from 0.34 to 0.39 nm, increasing with decreasing tube diameter. A model based on the results from real space image analysis is used to explain the variation in inter-shell spacings obtained from reciprocal space periodicity analysis. The increase in inter-shell spacing with decreased nanotube diameter is attributed to the high curvature, resulting in an increased repulsive force, associated with the decreased diameter of the nanotube shells.Comment: 4 pages. RevTeX. 4 figure

A Monolithic Time Stretcher for Precision Time Recording

Identifying light mesons which contain only up/down quarks (pions) from those containing a strange quark (kaons) over the typical meter length scales of a particle physics detector requires instrumentation capable of measuring flight times with a resolution on the order of 20ps. In the last few years a large number of inexpensive, multi-channel Time-to-Digital Converter (TDC) chips have become available. These devices typically have timing resolution performance in the hundreds of ps regime. A technique is presented that is a monolithic version of ``time stretcher'' solution adopted for the Belle Time-Of-Flight system to address this gap between resolution need and intrinsic multi-hit TDC performance.Comment: 9 pages, 15 figures, minor corrections made, to appear as JINST_008

Raman imaging and electronic properties of graphene

Graphite is a well-studied material with known electronic and optical properties. Graphene, on the other hand, which is just one layer of carbon atoms arranged in a hexagonal lattice, has been studied theoretically for quite some time but has only recently become accessible for experiments. Here we demonstrate how single- and multi-layer graphene can be unambiguously identified using Raman scattering. Furthermore, we use a scanning Raman set-up to image few-layer graphene flakes of various heights. In transport experiments we measure weak localization and conductance fluctuations in a graphene flake of about 7 monolayer thickness. We obtain a phase-coherence length of about 2 $\mu$m at a temperature of 2 K. Furthermore we investigate the conductivity through single-layer graphene flakes and the tuning of electron and hole densities via a back gate

Characteristics of the terrestrial field-aligned current system

We present the first ever comprehensive statistical study of the spatiotemporal characteristics of field-aligned currents in the terrestrial magnetosphere-ionosphere system using multi point measurements. We determine how the FAC density, variability and scale size are coupled. The three ST 5 satellites were in a pearls-on-a-string formation making measurements of the magnetic field with variable inter-spacecraft separations ranging from a few seconds to about 10 min. More than 4700 sets of satellite passes are analyzed using a robust correlation analysis aimed at determining the variability of the FAC system as a function of scale size and satellite spacing. We find significant differences between the FAC characteristics on the dayside and on the nightside in terms of dynamics of the current systems. On the dayside the FAC characteristics are found to be independent of IMF <I>B</I>_z and geomagnetic activity while the nightside indicates increased variability during disturbed conditions. The boundary separating highly and poorly correlated FACs can be fitted by a linear line for satellite separations shorter than 60 s (dayside) and 160 s (nightside). We interpret this as the dayside and nightside magnetospheric reconfiguration times respectively. For times exceeding this the FAC characteristics are suggested to be controlled by the solar wind (dayside) and plasma sheet (nightside) dynamics. Finally, the characteristics of FAC system with scale sizes larger than ~200 km (at ionospheric altitude) appear to be stable and repeatable on time scales of the order of a minute (i.e. comparable to the low-altitude orbiting satellite's traverse time across the auroral belt). In this sense, our results effectively validate the Iijima and Potemra (1978) assumption that on average the large-scale currents with scale sizes of the Region1 and Region2 are quasi-persistently significant in the transport of energy and momentum between the magnetosphere and the ionosphere

Superlattice properties of carbon nanotubes in a transverse electric field

Electron motion in a (n,1) carbon nanotube is shown to correspond to a de Broglie wave propagating along a helical line on the nanotube wall. This helical motion leads to periodicity of the electron potential energy in the presence of an electric field normal to the nanotube axis. The period of this potential is proportional to the nanotube radius and is greater than the interatomic distance in the nanotube. As a result, the behavior of an electron in a (n,1) nanotube subject to a transverse electric field is similar to that in a semiconductor superlattice. In particular, Bragg scattering of electrons from the long-range periodic potential results in the opening of gaps in the energy spectrum of the nanotube. Modification of the bandstructure is shown to be significant for experimentally attainable electric fields, which raises the possibility of applying this effect to novel nanoelectronic devices.Comment: 7 pages, 3 figure

Possible Superconductivity at 37 K in Graphite-Sulfur Composite

Sulfur intercalated graphite composites with diamagnetic transitions at 6.7 K and 37 K are prepared. The magnetization hysteresis loops (MHL), Xray diffraction patterns, and resistance were measured. From the MHL, a slight superconducting like penetration process is observed at 15 K in low field region. The XRD shows no big difference from the mixture of graphite and sulfur indicating that the volume of the superconducting phase (if any) is very small. The temperature dependence of resistance shows a typical semiconducting behavior with a saturation in low temperature region. This saturation is either induced by the de-localization of conducting electrons or by possible superconductivity in this system.Comment: CHIN. PHYS.LETT v18 1648 (2001