668 research outputs found
The individualised needs for service assessment (INSA) for children and adolescents with serious emotional disturbance
The Individualised Needs for Service Assessment (INSA) for children and adolescents with serious emotional disturbance was developed in response to the lack of a systematic approach to needs assessment compatible with individualised service planning. Functioning is assessed for 10 functional domains. Service providers rate service provision using a taxonomy of generic service items that are generalisable and comprehensible across different organisational units and systems of care. In addition, service providers rate the anticipated clinical effectiveness of each service item and the acceptability of each item to the child or adolescent and family. Drawing on a similar logic structure to that characterising the Needs for Care Assessment of the British Medical Research Council, these data are linked to produce a need status, for example unmet need, no need and met need. The INSA may be suitable for use by service providers, planners, policy makers, researchers, managed care organisations and service purchasers
Employees’ responses to an organizational merger: Intraindividual change in organizational identification, attachment, and turnover
The authors used pre-post merger data from 599 employees experiencing a major corporate merger to compare 3 conceptual models based on the logic of social identity theory (SIT) and exchange theory to explain employees’ merger responses. At issue is how perceived change in employees’ own jobs and roles (i.e., personal valence) and perceived change in their organization’s status and merger appropriateness (i.e., organizational valence) affect their changing organizational identification, attachment attitudes, and voluntary turnover. The first model suggests that organizational identification and organizational attachment develop independently and have distinct antecedents. The second model posits that organizational identification mediates the relationships between change in organizational and personal valence and change in attachment and turnover. The third model posits that change in personal valence moderates the relationship between changes in organizational valence and in organizational identification and attachment. Using latent difference score (LDS) modeling in an SEM framework and survival analysis, the results suggest an emergent fourth model that integrates the first and second models: Although change in organizational identification during the merger mediates the relationship between change in personal status and organizational valence and change in attachment, there is a direct and unmediated relationship between change in personal valence and attachment. This integrated model has implications for M&A theory and practice
Towards an Achievable Performance for the Loop Nests
Numerous code optimization techniques, including loop nest optimizations,
have been developed over the last four decades. Loop optimization techniques
transform loop nests to improve the performance of the code on a target
architecture, including exposing parallelism. Finding and evaluating an
optimal, semantic-preserving sequence of transformations is a complex problem.
The sequence is guided using heuristics and/or analytical models and there is
no way of knowing how close it gets to optimal performance or if there is any
headroom for improvement. This paper makes two contributions. First, it uses a
comparative analysis of loop optimizations/transformations across multiple
compilers to determine how much headroom may exist for each compiler. And
second, it presents an approach to characterize the loop nests based on their
hardware performance counter values and a Machine Learning approach that
predicts which compiler will generate the fastest code for a loop nest. The
prediction is made for both auto-vectorized, serial compilation and for
auto-parallelization. The results show that the headroom for state-of-the-art
compilers ranges from 1.10x to 1.42x for the serial code and from 1.30x to
1.71x for the auto-parallelized code. These results are based on the Machine
Learning predictions.Comment: Accepted at the 31st International Workshop on Languages and
Compilers for Parallel Computing (LCPC 2018
Completion of BAX recruitment correlates with mitochondrial fission during apoptosis
BAX, a member of the BCL2 gene family, controls the committed step of the intrinsic apoptotic program. Mitochondrial fragmentation is a commonly observed feature of apoptosis, which occurs through the process of mitochondrial fission. BAX has consistently been associated with mitochondrial fission, yet how BAX participates in the process of mitochondrial fragmentation during apoptosis remains to be tested. Time-lapse imaging of BAX recruitment and mitochondrial fragmentation demonstrates that rapid mitochondrial fragmentation during apoptosis occurs after the complete recruitment of BAX to the mitochondrial outer membrane (MOM). The requirement of a fully functioning BAX protein for the fission process was demonstrated further in BAX/BAK-deficient HCT116 cells expressing a P168A mutant of BAX. The mutant performed fusion to restore the mitochondrial network. but was not demonstrably recruited to the MOM after apoptosis induction. Under these conditions, mitochondrial fragmentation was blocked. Additionally, we show that loss of the fission protein, dynamin-like protein 1 (DRP1), does not temporally affect the initiation time or rate of BAX recruitment, but does reduce the final level of BAX recruited to the MOM during the late phase of BAX recruitment. These correlative observations suggest a model where late-stage BAX oligomers play a functional part of the mitochondrial fragmentation machinery in apoptotic cells
An axiomatic approach to the non-linear theory of generalized functions and consistency of Laplace transforms
We offer an axiomatic definition of a differential algebra of generalized
functions over an algebraically closed non-Archimedean field. This algebra is
of Colombeau type in the sense that it contains a copy of the space of Schwartz
distributions. We study the uniqueness of the objects we define and the
consistency of our axioms. Next, we identify an inconsistency in the
conventional Laplace transform theory. As an application we offer a free of
contradictions alternative in the framework of our algebra of generalized
functions. The article is aimed at mathematicians, physicists and engineers who
are interested in the non-linear theory of generalized functions, but who are
not necessarily familiar with the original Colombeau theory. We assume,
however, some basic familiarity with the Schwartz theory of distributions.Comment: 23 page
Testing the differential adhesion hypothesis across the epithelial− mesenchymal transition
Weanalyze the mechanical properties of three epithelial/mesenchymal cell lines (MCF-10A, MDAMB-
231, MDA-MB-436) that exhibit a shift in E-, N- and P-cadherin levels characteristic of an
epithelial−mesenchymal transition associated with processes such as metastasis, to quantify the role of
cell cohesion in cell sorting and compartmentalization. Wedevelop a unique set of methods to
measure cell–cell adhesiveness, cell stiffness and cell shapes, and compare the results to predictions
from cell sorting in mixtures of cell populations.Wefind that the final sorted state is extremely robust
among all three cell lines independent of epithelial or mesenchymal state, suggesting that cell sorting
may play an important role in organization and boundary formation in tumours.Wefind that surface
densities of adhesive molecules do not correlate with measured cell–cell adhesion, but do correlate
with cell shapes, cell stiffness and the rate at which cells sort, in accordance with an extended version of
the differential adhesion hypothesis (DAH). Surprisingly, theDAHdoes not correctly predict the final
sorted state. This suggests that these tissues are not behaving as immiscible fluids, and that dynamical
effects such as directional motility, friction and jamming may play an important role in tissue
compartmentalization across the epithelial−mesenchymal transition
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Co-hydrothermal carbonization as a potential method of utilising digested sludge and screenings from wastewater treatment plants towards energy application
Data availability:
No data was used for the research described in the article.Anaerobic digestion is one of the most recommended methods for utilising sewage sludge produced by wastewater treatment plants. However, the increasing amount of micropollutants in digested sludge can significantly limit its future utilisation. Recent studies suggests that the hydrothermal carbonization process can be used as a complementary method for sludge management, due to the improved quality of solid products - hydrochar. Moreover, this allows for the possibility of reusing liquid by-products in the anaerobic digestion process for biogas production. However, hydrochar generated from hydrothermal carbonisation has a higher concentration of heavy metals and low energy value, which limits its use in agriculture and energy sectors. This study highlights a partial resolution to this problem, by mixing digested sludge with screenings in the co-hydrothermal carbonisation process. The findings of this study show improvements in the properties of hydrochar including total solids measured according to ISO, inorganic fractions determined by inductively coupled plasma optical emission spectrometry and higher calorific values measured by the calorimetric bomb. Biomethane potential tests were conducted on liquid by-products. The results showed an average increase in biomethane potential from liquids obtained from co-hydrothermal carbonization compared to liquids from hydrothermal carbonization of digested sludge without screenings in series 1, 2 and 3 - up to 60%, 40% and 26% for three different sludges with initial total solids content of 2.6%, 12.5% and 21.5% w/w.The study was co-carried out in the framework of the statutory funds for research, co-financed by the Ministry of Science and Higher Education BS/PB-400-301/24
Optimizing end-labeled free-solution electrophoresis by increasing the hydrodynamic friction of the drag-tag
We study the electrophoretic separation of polyelectrolytes of varying
lengths by means of end-labeled free-solution electrophoresis (ELFSE). A
coarse-grained molecular dynamics simulation model, using full electrostatic
interactions and a mesoscopic Lattice Boltzmann fluid to account for
hydrodynamic interactions, is used to characterize the drag coefficients of
different label types: linear and branched polymeric labels, as well as
transiently bound micelles.
It is specifically shown that the label's drag coefficient is determined by
its hydrodynamic size, and that the drag per label monomer is largest for
linear labels. However, the addition of side chains to a linear label offers
the possibility to increase the hydrodynamic size, and therefore the label
efficiency, without having to increase the linear length of the label, thereby
simplifying synthesis. The third class of labels investigated, transiently
bound micelles, seems very promising for the usage in ELFSE, as they provide a
significant higher hydrodynamic drag than the other label types.
The results are compared to theoretical predictions, and we investigate how
the efficiency of the ELFSE method can be improved by using smartly designed
drag-tags.Comment: 32 pages, 11 figures, submitted to Macromolecule
Dynamical extensions for shell-crossing singularities
We derive global weak solutions of Einstein's equations for spherically
symmetric dust-filled space-times which admit shell-crossing singularities. In
the marginally bound case, the solutions are weak solutions of a conservation
law. In the non-marginally bound case, the equations are solved in a
generalized sense involving metric functions of bounded variation. The
solutions are not unique to the future of the shell-crossing singularity, which
is replaced by a shock wave in the present treatment; the metric is bounded but
not continuous.Comment: 14 pages, 1 figur
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