Panel Discussion: Expropriation, Threats of Expropriation and Developmental Policy

This panel discussion is a conversation about the place of expropriation in international law

CLOVER - A new instrument for measuring the B-mode polarization of the CMB

We describe the design and expected performance of Clover, a new instrument designed to measure the B-mode polarization of the cosmic microwave background. The proposed instrument will comprise three independent telescopes operating at 90, 150 and 220 GHz and is planned to be sited at Dome C, Antarctica. Each telescope will feed a focal plane array of 128 background-limited detectors and will measure polarized signals over angular multipoles 20 < l < 1000. The unique design of the telescope and careful control of systematics should enable the B-mode signature of gravitational waves to be measured to a lensing-confusion-limited tensor-to-scalar ratio r~0.005.Comment: 4 pages, 5 figures. To appear in the proceedings of the XXXVIXth Rencontres de Moriond "Exploring the Universe

The Causal Structure of Emotions in Aristotle: Hylomorphism, Causal Interaction between Mind and Body, and Intentionality

Recently, a strong hylomorphic reading of Aristotelian emotions has been put forward, one that allegedly eliminates the problem of causal interaction between soul and body. Taking the presentation of emotions in de An. I 1 as a starting point and basic thread, but relying also on the discussion of Rh. II, I will argue that this reading only takes into account two of the four causes of emotions, and that, if all four of them are included into the picture, then a causal interaction of mind and body remains within Aristotelian emotions, independent of how strongly their hylomorphism is understood. Beyond the discussion with this recent reading, the analysis proposed of the fourfold causal structure of emotions is also intended as a hermeneutical starting point for a comprehensive analysis of particular emotions in Aristotle. Through the different causes Aristotle seems to account for many aspects of the complex phenomenon of emotion, including its physiological causes, its mental causes, and its intentional object

Cost-effectiveness of Human Papillomavirus Vaccination in the United States

Results of a simplified model were consistent with published studies based on more complex models when key assumptions were similar

Panel Discussion: Refinancing of Third World Debt

Today\u27s topic, Refinancing of Third World Debt, will be broken into two discussions, the first dealing with the private sector; the second with the public sector. We will begin our first session by comparing the credit worthiness of the Second World, the Communist world, to that of the developing countries that we call the Third World

Prototype finline-coupled TES bolometers for CLOVER

CLOVER is an experiment which aims to detect the signature of gravitational waves from inflation by measuring the B-mode polarization of the cosmic microwave background. CLOVER consists of three telescopes operating at 97, 150, and 220 GHz. The 97-GHz telescope has 160 feedhorns in its focal plane while the 150 and 220-GHz telescopes have 256 horns each. The horns are arranged in a hexagonal array and feed a polarimeter which uses finline-coupled TES bolometers as detectors. To detect the two polarizations the 97-GHz telescope has 320 detectors while the 150 and 220-GHz telescopes have 512 detectors each. To achieve the target NEPs (1.5, 2.5, and 4.5x10^-17 W/rtHz) the detectors are cooled to 100 mK for the 97 and 150-GHz polarimeters and 230 mK for the 220-GHz polarimeter. Each detector is fabricated as a single chip to ensure a 100% operational focal plane. The detectors are contained in linear modules made of copper which form split-block waveguides. The detector modules contain 16 or 20 detectors each for compatibility with the hexagonal arrays of horns in the telescopes' focal planes. Each detector module contains a time-division SQUID multiplexer to read out the detectors. Further amplification of the multiplexed signals is provided by SQUID series arrays. The first prototype detectors for CLOVER operate with a bath temperature of 230 mK and are used to validate the detector design as well as the polarimeter technology. We describe the design of the CLOVER detectors, detector blocks, and readout, and present preliminary measurements of the prototype detectors performance.Comment: 4 pages, 6 figures; to appear in the Proceedings of the 17th International Symposium on Space Terahertz Technology, held 10-12 May 2006 in Pari

FRMD4A Upregulation in Human Squamous Cell Carcinoma Promotes Tumor Growth and Metastasis and Is Associated with Poor Prognosis

New therapeutic strategies are needed to improve treatment of head and neck squamous cell carcinoma (HNSCC), an aggressive tumor with poor survival rates. FRMD4A is a human epidermal stem cell marker implicated previously in epithelial polarity that is upregulated in SCC cells. Here, we report that FRMD4A upregulation occurs in primary human HNSCCs where high expression levels correlate with increased risks of relapse. FRMD4A silencing decreased growth and metastasis of human SCC xenografts in skin and tongue, reduced SCC proliferation and intercellular adhesion, and stimulated caspase-3 activity and expression of terminal differentiation markers. Notably, FRMD4A attenuation caused nuclear accumulation of YAP, suggesting a potential role for FRMD4A in Hippo signaling. Treatment with the HSP90 inhibitor 17-DMAG or ligation of CD44 with hyaluronan caused nuclear depletion of FRMD4A, nuclear accumulation of YAP and reduced SCC growth and metastasis. Together, our findings suggest FRMD4A as a novel candidate therapeutic target in HNSCC based on the key role in metastatic growth we have identified

Dynamics of nonequilibrium quasiparticles in a double superconducting tunnel junction detector

We study a class of superconductive radiation detectors in which the absorption of energy occurs in a long superconductive strip while the redout stage is provided by superconductive tunnel junctions positioned at the two ends of the strip. Such a device is capable both of imaging and energy resolution. In the established current scheme, well studied from the theoretical and experimental point of view, a fundamental ingredient is considered the presence of traps, or regions adjacent to the junctions made of a superconducting material of lower gap. We reconsider the problem by investigating the dynamics of the radiation induced excess quasiparticles in a simpler device, i.e. one without traps. The nonequilibrium excess quasiparticles can be seen to obey a diffusion equation whose coefficients are discontinuous functions of the position. Based on the analytical solution to this equation, we follow the dynamics of the quasiparticles in the device, predict the signal formation of the detector and discuss the potentiality offered by this configuration.Comment: 16 pages, 5 figures Submitted to Superconducting Science and Technolog

Continuous time volatility modelling: COGARCH versus Ornstein-Uhlenbeck models

We compare the probabilistic properties of the non-Gaussian Ornstein-Uhlenbeck based stochastic volatility model of Barndorff-Nielsen and Shephard (2001) with those of the COGARCH process. The latter is a continuous time GARCH process introduced by the authors (2004). Many features are shown to be shared by both processes, but differences are pointed out as well. Furthermore, it is shown that the COGARCH process has Pareto like tails under weak regularity conditions