Evaluation of ignition mechanisms in selected spacecraft materials Final report, 1 Mar. - 30 Jun. 1967

Evaluation of ignition mechanisms for spacecraft materials in simulated spacecraft cabin atmosphere

Evaluation of ignition mechanisms in selected nonmetallic materials

Test program evaluates thermal and electric ignition mechanisms in selected nonmetallic materials found in spacecraft with concentrated oxygen atmospheres. The phenomena evaluated were spontaneous ignition, ignition of flammable vapor by a spark, and ignition by an arc where the arc produces the combustible vapor and the ignition source

The role of the slope of `realistic' potential barriers in preventing relativistic tunnelling in the Klein zone

The transmission of fermions of mass m and energy E through an electrostatic potential barrier of rectangular shape (i.e. supporting an infinite electric field), of height U> E + m - due to the many-body nature of the Dirac equation evidentiated by the Klein paradox - has been widely studied. We exploit here the analytical solution, given by Sauter for the linearly rising potential step, to show that the tunnelling rate through a more realistic trapezoidal barrier is exponentially depressed, as soon as the length of the regions supporting a finite electric field exceeds the Compton wavelenght of the particle - the latter circumstance being hardly escapable in most realistic cases

Anisotropy of the Cosmic Neutrino Background

The cosmic neutrino background (CNB) consists of low-energy relic neutrinos which decoupled from the cosmological fluid at a redshift z ~ 10^{10}. Despite being the second-most abundant particles in the universe, direct observation remains a distant challenge. Based on the measured neutrino mass differences, one species of neutrinos may still be relativistic with a thermal distribution characterized by the temperature T ~ 1.9K. We show that the temperature distribution on the sky is anisotropic, much like the photon background, experiencing Sachs-Wolfe and integrated Sachs-Wolfe effects.Comment: 5 pages, 2 figures / updated references, discussion of earlier wor

Spectra of Discrete Schr\"odinger Operators with Primitive Invertible Substitution Potentials

We study the spectral properties of discrete Schr\"odinger operators with potentials given by primitive invertible substitution sequences (or by Sturmian sequences whose rotation angle has an eventually periodic continued fraction expansion, a strictly larger class than primitive invertible substitution sequences). It is known that operators from this family have spectra which are Cantor sets of zero Lebesgue measure. We show that the Hausdorff dimension of this set tends to $1$ as coupling constant $\lambda$ tends to $0$. Moreover, we also show that at small coupling constant, all gaps allowed by the gap labeling theorem are open and furthermore open linearly with respect to $\lambda$. Additionally, we show that, in the small coupling regime, the density of states measure for an operator in this family is exact dimensional. The dimension of the density of states measure is strictly smaller than the Hausdorff dimension of the spectrum and tends to $1$ as $\lambda$ tends to $0$

Standard Model Neutrinos as Warm Dark Matter

Standard Model neutrinos are not usually considered plausible dark matter candidates because the usual treatment of their decoupling in the early universe implies that their mass must be sufficiently small to make them ``hot'' dark matter. In this paper we show that decoupling of Standard Model neutrinos in low reheat models may result in neutrino densities very much less than usually assumed, and thus their mass may be in the keV range. Standard Model neutrinos may therefore be warm dark matter candidates.Comment: 5 pages, 5 figures, LaTeX file uses revtex packag

Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches

SummaryA comprehensive understanding of the cellular functions of the Hsp90 molecular chaperone has remained elusive. Although Hsp90 is essential, highly abundant under normal conditions, and further induced by environmental stress, only a limited number of Hsp90 “clients” have been identified. To define Hsp90 function, a panel of genome-wide chemical-genetic screens in Saccharomyces cerevisiae were combined with bioinformatic analyses. This approach identified several unanticipated functions of Hsp90 under normal conditions and in response to stress. Under normal growth conditions, Hsp90 plays a major role in various aspects of the secretory pathway and cellular transport; during environmental stress, Hsp90 is required for the cell cycle, meiosis, and cytokinesis. Importantly, biochemical and cell biological analyses validated several of these Hsp90-dependent functions, highlighting the potential of our integrated global approach to uncover chaperone functions in the cell

Introduction to Chiral Perturbation Theory

A brief introduction to chiral perturbation theory, the effective field theory of quantum chromodynamics at low energies, is given.Comment: 26 pages, 11 figures. Lectures given at the summer school ISSSMB 2006 in Akyaka, Turkey, September 200

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via V(D)J recombination. Here we provide a comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior to and during V(D)J recombination. DNA methylation did not correlate with the histone modification state on unrearranged alleles, indicating that these epigenetic marks were regulated independently. Instead, pockets of tissue-specific demethylation were restricted to DNase I hypersensitive sites within this locus. Though unrearranged diversity (DH) and joining (JH) gene segments were methylated, DJH junctions created after the first recombination step were largely demethylated in pro-, pre-, and mature B cells. Junctional demethylation was highly localized, B-lineage-specific, and required an intact tissue-specific enhancer, Eμ. We propose that demethylation occurs after the first recombination step and may mark the junction for secondary recombination