Unsteady laminar boundary-layer calculations on oscillating configurations including backflow. Part 2: Airfoil in high-amplitude pitching motion. Dynamic stall

A previously developed finite-difference procedure for calculating unsteady, incompressible, laminar boundary layers on an oscillating flat plate is applied to a wing section undergoing high-amplitude pitching oscillations about various mean incidences. To start the entire boundary-layer calculation, appropriate initial conditions and outer boundary conditions are specified, using a stagnation-point fixed frame of reference. The breakdown of the numerical calculation procedure in the x,t-domain is interpreted to coincide with unsteady separation. Details of the boundary-layer behavior in the vicinity of separation are investigated, and a close analogy between the present results and those for a three-dimensional steady separation is found

Unsteady laminar boundary-layer calculations on oscillating configurations including backflow. Part 1: Flat plate, oscillating in its own plane

A finite difference method has been developed to calculate the unsteady boundary layer over an oscillating flat plate. Low- and high frequency approximations were used for comparison with numerical results. Special emphasis was placed on the behavior of the flow and on the numerical calculation procedure as soon as reversed flow has occurred over part of the oscillation cycle. The numerical method displayed neither problems nor singular behavior at the beginning of or within the reversed flow region. Calculations, however, came to a limit where the back-flow region reached the plate's leading edge in the case of high oscillation amplitudes. It is assumed that this limit is caused by the special behavior of the flow at the plate's leading edge where the boundary layer equations are not valid

Synchronization of unidirectional time delay chaotic networks and the greatest common divisor

We present the interplay between synchronization of unidirectional coupled chaotic nodes with heterogeneous delays and the greatest common divisor (GCD) of loops composing the oriented graph. In the weak chaos region and for GCD=1 the network is in chaotic zero-lag synchronization, whereas for GCD=m>1 synchronization of m-sublattices emerges. Complete synchronization can be achieved when all chaotic nodes are influenced by an identical set of delays and in particular for the limiting case of homogeneous delays. Results are supported by simulations of chaotic systems, self-consistent and mixing arguments, as well as analytical solutions of Bernoulli maps.Comment: 7 pages, 5 figure

A feasibility study of orbiter flight control experiments

The results of a feasibility study of orbiter flight control experiments performed are summarized. Feasibility studies were performed on a group of 14 experiments selected from a candidate list of 35 submitted to the study contractor by the flight control community. Concepts and requirements were developed for the 14 selected experiments and they were ranked on a basis of technical value, feasibility, and cost. It was concluded that all the selected experiments can be considered as potential candidates for the Orbiter Experiment program, which is being formulated for the Orbiter Flight Tests and subsequent operational flights, regardless of the relative ranking established during the study. None of the selected experiments has significant safety implications and the cost of most was estimated to be less than $200K

A Case Study in the Implementation of a Human-Centric Higher Education Cybersecurity Program

This article contains a description of the implementation of a comprehensive cyber security program at a regional comprehensive university. The program was designed to create an effective cyber security management infrastructure and to train end users and other categories of security management personnel in data protection and cyber security. This work addresses the impetus for the program, the rather extensive planning and development that went into the program, its implementation, and insights gleaned from the experience. The paper concludes with a summary of the strengths and weaknesses of the initiative

TRISTAN: Electromagnetic, gravimetric and seismic measurements to investigate the Tristan da Cunha hot spot and its role in the opening of the South-Atlantic - Cruise No. MSM20/2, January 17 - February 15, 2012, Walvis Bay (Namibia) – Recife (Brazil)

According to classical plume theory, the Tristan da Cunha hotspot is thought to have played a major role in the rifting of the South Atlantic margins and the creation of the aseismic Walvis Ridge by impinging at the base of the continental lithosphere shortly before or during the breakup of the South Atlantic margins. But Tristan da Cunha is enigmatic, as it cannot be clearly identified as a hot-spot but classifies also highly as a more shallow type of anomaly that may actually have been caused by the opening of the South Atlantic. The equivocal character of Tristan is largely due to lack of geophysical data in this region. To understand the tectonic processes of the opening of the South Atlantic, the formation of the Walvis ridge and to understand whether Tristan da Cunha is the cause or the consequence of rifting, it is of central importance to characterize the region around Tristan da Cunha in a more coherent way. Within this research cruise we deployed 26 ocean bottom electromagnetic stations (OEBM) and 24 ocean bottom seismometer (OBS) for a long term acquisition (1 year) of magnetotelluric and seismological data, acquired bathymetry and gravity data and performed geological sampling on Tristan da Cunha. The data will be interpreted in the context of geochemical data and tectonic models developed within the SPP1375‚ South Atlantic Margin Processes and Links with onshore Evolution (SAMPLE)

Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells

Background: The studies reported herein were undertaken to determine if the angiostatic function of p53 could be exploited as an adjunct to VEGF-targeted therapy in the treatment of renal cell carcinoma (RCC). Methods: Nude/beige mice bearing human RCC xenografts were treated with various combinations of sunitinib and the HDM2 antagonist MI-319. Tumors were excised at various time points before and during treatment and analyzed by western blot and IHC for evidence of p53 activation and function. Results: Sunitinib treatment increased p53 levels in RCC xenografts and transiently induced the expression of p21waf1, Noxa, and HDM2, the levels of which subsequently declined to baseline (or undetectable) with the emergence of sunitinib resistance. The development of resistance and the suppression of p53-dependent gene expression temporally correlated with the induction of the p53 antagonist HDMX. The concurrent administration of MI-319 markedly increased the antitumor and anti-angiogenic activities of sunitinib and led to sustained p53-dependent gene expression. It also suppressed the expression of the chemokine SDF-1 (CXCL12) and the influx of CD11b+/Gr-1+ myeloid-derived suppressor cells (MDSC) otherwise induced by sunitinib. Although p53 knockdown markedly reduced the production of the angiostatic peptide endostatin, the production of endostatin was not augmented by MI-319 treatment. Conclusions: The evasion of p53 function (possibly through the expression of HDMX) is an essential element in the development of resistance to VEGF-targeted therapy in RCC. The maintenance of p53 function through the concurrent administration of an HDM2 antagonist is an effective means of delaying or preventing the development of resistance

Transferable Pair Potentials for CdS and ZnS Crystals

A set of interatomic pair potentials is developed for CdS and ZnS crystals. We show that a simple energy function, which has been used to describe the properties of CdSe [J. Chem. Phys. 116, 258 (2002)], can be parametrized to accurately describe the lattice and elastic constants, and phonon dispersion relations of bulk CdS and ZnS in the wurtzite and rocksalt crystal structures. The predicted coexistence pressure of the wurtzite and rocksalt structures, as well as the equation of state are in good agreement with experimental observations. These new pair potentials enable the study of a wide range of processes in bulk and nanocrystalline II-VI semiconductor materials

Feasibility study and design concept for an orbiting ice-penetrating radar sounder to characterize in three-dimensions the Europan ice mantle down to (and including) any ice/ocean interface

This report presents a radar sounding model based on the range of current working hypotheses for the nature of Europa's icy shell.Institute for Geophysic

Nonlocal mechanism for cluster synchronization in neural circuits

The interplay between the topology of cortical circuits and synchronized activity modes in distinct cortical areas is a key enigma in neuroscience. We present a new nonlocal mechanism governing the periodic activity mode: the greatest common divisor (GCD) of network loops. For a stimulus to one node, the network splits into GCD-clusters in which cluster neurons are in zero-lag synchronization. For complex external stimuli, the number of clusters can be any common divisor. The synchronized mode and the transients to synchronization pinpoint the type of external stimuli. The findings, supported by an information mixing argument and simulations of Hodgkin Huxley population dynamic networks with unidirectional connectivity and synaptic noise, call for reexamining sources of correlated activity in cortex and shorter information processing time scales.Comment: 8 pges, 6 figure