Black Holes at Future Colliders and Beyond: a Topical Review

One of the most dramatic consequences of low-scale (~1 TeV) quantum gravity in models with large or warped extra dimension(s) is copious production of mini black holes at future colliders and in ultra-high-energy cosmic ray collisions. Hawking radiation of these black holes is expected to be constrained mainly to our three-dimensional world and results in rich phenomenology. In this topical review we discuss the current status of astrophysical observations of black holes and selected aspects of mini black hole phenomenology, such as production at colliders and in cosmic rays, black hole decay properties, Hawking radiation as a sensitive probe of the dimensionality of extra space, as well as an exciting possibility of finding new physics in the decays of black holes.Comment: 31 pages, 10 figures To appear in the Journal of Physics

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

Abstract Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of cutaneous T-cell lymphoma. Like vorinostat, most of the small-molecule HDAC inhibitors in clinical development are hydroxamic acids, whose inhibitory activity stems from their ability to coordinate the catalytic Zn 2+ in the active site of HDACs. We sought to identify novel, nonhydroxamate-based HDAC inhibitors with potentially distinct pharmaceutical properties via an ultra-high throughput small molecule biochemical screen against the HDAC activity in a HeLa cell nuclear extract. An A-mercaptoketone series was identified and chemically optimized. The lead compound, KD5170, exhibits HDAC inhibitory activity with an IC 50 of 0.045 Mmol/L in the screening biochemical assay and an EC 50 of 0.025 Mmol/L in HeLa cell -based assays that monitor histone H3 acetylation. KD5170 also exhibits broad spectrum classe

Enterocolitis necrotizante en recién nacidos ingresados en el Servicio de Neonatología del Hospital Escuela "Carlos Roberto Huembes" en el período comprendido de Enero 2011 a Diciembre 2013

La enterocolitis necrotizante en el recién nacido presenta un amplio espectro de manifestaciones clínicas, caracterizándose principalmente por la tríada de distensión abdominal, sangramiento gastrointestinal y neumatosis intestinal. A pesar del avance en el cuidado intensivo neonatal, persiste como una enfermedad grave, que afecta habitualmente al recién nacido pretérmino, especialmente de muy bajo peso

Eimerians from Different Karyotypes of the Japanese Wood Mouse (\u3ci\u3eApodemus\u3c/i\u3e spp.), with Descriptions of Two New Species and a Redescription of \u3ci\u3eEimeria montgomeryae\u3c/i\u3e Lewis and Ball, 1983

Examination of 131 wood mice (Apodemus spp.) representing 2 species and 6 subspecies collected from the Japanese islands of Hokkaido, Honshu, Kyushu, and Tsushima showed that 70 mice (53%) had coccidian oocysts in their feces. These included 21 of 42 (50%) Apodemus argenteus argenteus; 7 of 14 (50%) Apodemus argenteus hokkaidi; 2 of 3 (67%) Apodemus argenteus sagax; 3 of 9 (33%) Apodemus speciosus ainu; 36 of 61 (59%) Apodemus speciosus speciosus; and 1 of 2 (50%) Apodemus speciosus tusimaensis. Four distinct coccidians were identified: Eimeria argenteus n. sp. from A. a. argenteus, A. a. hokkaidi, A. a. sagax, and A. s. speciosus; Eimeria inuyamensis n. sp. from A. a. argenteus, A. s. speciosus, and A. s. tusimaensis; Eimeria montgomeryae Lewis and Ball, 1983, from A. a. argenteus, A. a. hokkaidi, A. a. sagax, A. s. ainu, and A. s. speciosus; and Eimeria uptoni Lewis and Ball, 1983, from A. a. argenteus, A. a. hokkaidi, and A. s. speciosus. Standard karyotypes were prepared from selected specimens of each host subspecies. All 3 subspecies of A. argenteus and A. s. tusimaensis have a 2n = 46; A. s. ainu, from Hokkaido, has a 2n = 48; and A. s. speciosus has at least 2 chromosomal races, 1 on northern (2n = 48) and 1 on southern (2n = 46) Honshu. Both chromosomal races of A. s. speciosus, as well as the other subspecies of Apodemus examined, shared their coccidian parasites freely

Cross-Transmission Studies with \u3ci\u3eEimeria arizonensis\u3c/i\u3e-like Oocysts (Apicomplexa) in New World Rodents of the Genera \u3ci\u3eBaiomys\u3c/i\u3e, \u3ci\u3eNeotoma\u3c/i\u3e, \u3ci\u3eOnychomys\u3c/i\u3e, \u3ci\u3ePeromyscus\u3c/i\u3e, and \u3ci\u3eReithrodontomys\u3c/i\u3e (Muridae)

Cross-transmission experiments were performed using oocysts of an Eimeria arizonensis-like coccidian from Peromyscus leucopus and Peromyscus truei, an E. arizonensis-like coccidian from Reithrodontomys fulvescens, Eimeria baiomysis and Eimeria taylori from Baiomys taylori, Eimeria albigulae from Neotoma albigula, and Eimeria onychomysis from Onychomys spp., between representatives of the above host genera. The E. arizonensis-like coccidian from R. fulvescens infected Reithrodontomys megalotis, Reithrodontomys montanus, and Peromyscus leucopus. Oocysts of E. arizonensis from P. leucopus could be transmitted to both P. leucopus and R. megalotus. Oocysts of E. baiomysis and E. taylori infected only B. taylori. Oocysts of E. arizonensis from P. truei infected P. truei but not Neotoma mexicana or Onychomys leucogaster. Oocysts of E. albigulae from N. albigula were infective for N. mexicana but not for P. truei or O. leucogaster. Oocysts of E. onychomysis from Onychomys spp. infected O. leucogaster but not N. mexicana or P. truei. These results demonstrate that Peromyscus and Reithrodontomys, genera known to be related very closely evolutionarily, are capable of sharing E. arizonensis, whereas morphologically similar coccidians (E. albigulae, E. baiomysis, and E. onychomysis) from more distantly related hosts, are probably distinct and more stenoxenous. This also is the first report of coccidians infecting species of Reithrodontomys

Changes and Developments in Electron Cyclotron Resonant Heating (ECRH) on the Tandem Mirror Experiment Upgrade (TMX-U)

This paper will describe changes to the previously reported Electron Cyclotron Resonant Heating (ECRH) circular waveguide systems that deliver power to the Tandem Mirror Experiment Upgrade (TMX-U) machine. Four gyrotrons and associated waveguide systems, operating at 28-GHz and 200 kW each, helped establish electrostatic plugging in the end cells of TMX-U. A fifth gyrotron has been installed to power two resonant locations in the end plugs. This system and the pair of 10 kG heaters now use a slot radiator to obtain a more uniform coverage of the plasma. In addition, four 18-GHz ECRH systems have been added to the machine. 3 refs., 7 figs